CureVac Expands Lead RNA Cancer Program Phase 1 Trial in Advanced Melanoma CV8102 recommended dose identified; expansion trial to confirm safety, tolerability, and efficacy Trial expansion focuses on advanced melanoma, a

CureVac Expands Lead RNA Cancer Program Phase 1 Trial in

T BINGEN, Germany / BOSTON, USA - February 4,

2021 - CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines

based on messenger ribonucleic acid (mRNA), today announced the start of an expansion of the ongoing Phase 1 study with its lead

RNA-based cancer drug candidate, CV8102. Initial results from the dose-escalation part in four solid cancer types were presented

at the SITC conference in 2020. CV8102 had shown promising evidence of efficacy after intratumoral application as a single agent,

and in combination with systemic anti-PD-1 antibody treatment. Translation of a locally induced immune response into a systemic

immune response was observed in several patients, showing the ability of CV8102 to impact injected as well as distant lesions.

The objective of the expansion is to confirm safety, tolerability, and efficacy of CV8102 in patients with advanced melanoma at

600 g, the selected dose to be advanced in a Phase 2 clinical trial. Furthermore, the trial expansion will evaluate the effects

of CV8102 on systemic and intratumoral immune markers, which will provide additional clinical insights on CV8102's mode of

"Initial clinical data in cancer has demonstrated the

ability of our RNA immunomodulator to trigger a systemic immune response attacking cancer not only at the site of injection but

also in other areas of the body," said Ulrike Gnad-Vogt, Senior Vice President Area Head Oncology at CureVac. "The

CV8102 trial expansion is expected to provide further insights into clinical efficacy and mechanism of action in patients with

advanced PD-1 refractory melanoma, an indication with a high unmet medical need. We are very pleased to see CV8102 progress to

the next stage, an important step to further leverage the potential of immunostimulating RNA therapeutics in oncology."

The expansion part of the trial will enrol 30 patients with

PD-1 refractory melanoma, who will receive intratumoral injections of CV8102 in combination with PD-1 antibodies, as well as 10

patients who will be treated with CV8102 only. Initially, CV8102, with or without co-administration of anti-PD-1 treatment, will

be injected weekly for five weeks, followed by three injections at two- or three-week intervals depending on the anti-PD-1 antibody

schedule. Patients showing evidence of clinical benefit are eligible for further injections for up to 12 months.

CV8102 is a noncoding single stranded RNA complexed with a cationic

peptide and functions as a strong immunomodulator based on TLR (toll-like receptor) 7/8 and RIG-1 (retinoic-acid-inducible protein

1) activation. It is designed to modulate the tumor microenvironment following intratumoral injection and to translate a local

immune response towards released tumor antigens into a systemic immune response to control both injected as well as distant lesions.

The currently ongoing Phase 1 dose escalation study is assessing tolerability as well as activity of CV8102 in the dose range of

25 to 900 g. It is administered as both a single agent and in combination with systemic anti-PD-1 antibodies for the intratumoral

treatment of four types of solid tumors: cutaneous melanoma, adenoid cystic carcinoma, squamous cell carcinoma of the skin, and

squamous cell carcinoma of the head and neck. Initial results from the dose-escalation study presented at the SITC conference in

November 2020 showed that the 600 g dose was tolerated without dose limiting toxicities as a single agent and in combination

with anti-PD-1 antibodies. Preliminary evidence of efficacy was observed in the single agent and combination group, with several

patients showing responses of distant noninjected lesions.

CureVac is a global biopharmaceutical

company in the field of messenger RNA (mRNA) technology, with more than 20 years of expertise in developing and optimizing the

versatile biological molecule for medical purposes. The principle of CureVac's proprietary technology is the use of non-chemically

modified mRNA as a data carrier to instruct the human body to produce its own proteins capable of fighting a broad range of diseases.

Based on its proprietary technology, the company has built a deep clinical pipeline across the areas of prophylactic vaccines,

cancer therapies, antibody therapies, and the treatment of rare diseases. CureVac had its initial public offering on the New York

Nasdaq in August 2020. It is headquartered in T bingen, Germany, and employs more than 500 people at its sites in T bingen,

Frankfurt, and Boston, USA. Further information can be found at www.curevac.com.

CureVac Media Contact

Thorsten Sch ller, Vice President Communications

CureVac, T bingen, Germany

T: +49 7071 9883-1577

CureVac Investor Relations Contact

Dr. Sarah Fakih, Vice President Investor Relations

CureVac, T bingen, Germany

T: +49 7071 9883-1298

M: +49 160 90 496949

Forward-Looking Statements

This press release contains statements that constitute "forward

looking statements" as that term is defined in the United States Private Securities Litigation Reform Act of 1995, including

statements that express the opinions, expectations, beliefs, plans, objectives, assumptions or projections of CureVac (the "company")

regarding future events or future results, in contrast with statements that reflect historical facts. Examples include discussion

of the potential efficacy of the company's vaccine and treatment candidates and the company's strategies, financing

plans, growth opportunities and market growth. In some cases, you can identify such forward-looking statements by terminology such

as "anticipate," "intend," "believe," "estimate," "plan," "seek,"

"project," or "expect," "may," "will," "would," "could,"

"potential," "intend," or "should," the negative of these terms or similar expressions. Forward-looking

statements are based on management's current beliefs and assumptions and on information currently available to the company.

However, these forward-looking statements are not a guarantee of the company's performance, and you should not place undue

reliance on such statements. Forward-looking statements are subject to many risks, uncertainties and other variable circumstances,

including negative worldwide economic conditions and ongoing instability and volatility in the worldwide financial markets, ability

to obtain funding, ability to conduct current and future preclinical studies and clinical trials, the timing, expense and uncertainty

of regulatory approval, reliance on third parties and collaboration partners, ability to commercialize products, ability to manufacture

any products, possible changes in current and proposed legislation, regulations and governmental policies, pressures from increasing

competition and consolidation in the company's industry, the effects of the COVID-19 pandemic on the company's business

and results of operations, ability to manage growth, reliance on key personnel, reliance on intellectual property protection, ability

to provide for patient safety, and fluctuations of operating results due to the effect of exchange rates or other factors. Such

risks and uncertainties may cause the statements to be inaccurate and readers are cautioned not to place undue reliance on such

statements. Many of these risks are outside of the company's control and could cause its actual results to differ materially

from those it thought would occur. The forward-looking statements included in this press release are made only as of the date hereof.

The company does not undertake, and specifically declines, any obligation to update any such statements or to publicly announce

the results of any revisions to any such statements to reflect future events or developments, except as required by law.

For further information, please reference the company's

reports and documents filed with the U.S. Securities and Exchange Commission (SEC). You may get these documents by visiting EDGAR

on the SEC website at www.sec.gov.