Full Press Release Details
CureVac and Fareva Sign Agreement For Fill & Finish
Manufacturing of Curevac's COVID-19 Vaccine Candidate, CVnCoV
T BINGEN, Germany/ BOSTON, USA and Luxembourg -
December 9, 2020 - CureVac N.V. (Nasdaq: CVAC), a global clinical-stage biopharmaceutical company developing a new class
of transformative medicines based on messenger ribonucleic acid (mRNA), and Fareva today announced an agreement regarding the fill
& finish manufacturing of CureVac s COVID-19 vaccine candidate, CVnCoV, at Fareva's Pau and Val-de-Reuil-sites
"We are proud to contribute to the manufacturing of this
innovative vaccine candidate from CureVac. This agreement confirms Fareva's strategy of investing significantly in the areas
of sterile manufacturing, enlarging our technology offering," said Alexandre Bastit, Vice President of EMEA Pharma Sales
"We are pleased to partner with Fareva for the fill &
finish manufacturing of our COVID-19 vaccine candidate in France," added Dr. Florian von der M lbe, Chief Production
Officer of CureVac. "Fareva is an experienced and reliable partner that will help to increase the overall production capacity
for our vaccine, and by partly manufacturing our vaccine in France, we will hopefully be in a position to contribute to the protection
of French citizens against the virus."
CureVac is building an integrated European vaccine manufacturing
network with several Contract Development and Manufacturing Organization (CDMO) partners. With this strategy, the company will
significantly increase CureVac's existing manufacturing capacity, allowing CureVac to develop up to several hundred million
doses of its vaccines per year and to manage potential supply chain risks by working with partners during each of the key steps
in the manufacturing process.
Thanks to the agreement announced today, Fareva will provide
the production capacity for filling vials with the vaccine and the eluent at its sites in Pau and Val-de-Reuil, France, supporting
the production of millions of doses of CureVac's COVID-19 vaccine candidate. The mRNA vaccine will be supplied to Fareva
by CureVac. Fareva's Val-de-Reuil-site accounts for more than 500 employees and is dedicated to the manufacturing of sterile
Active Pharmaceutical Ingredients (APIs) and sterile finished dosage forms (e.g., lyophilized vials, prefilled syringes and ampoules).
Over the last 10 years, Fareva has invested over 80 million euros in this site and created 250 jobs. The site in Pau is a more
recent acquisition by Fareva from Pierre Fabre Group, and is supported by more than 250 employees. It is dedicated to the sterile
fill & finish manufacturing of biologics and high potent APIs, including freeze-dried products.
CureVac began development
of its mRNA-based COVID-19 vaccine candidate in January 2020. The compound is an optimized, non-chemically modified mRNA, encoding
the pre-fusion stabilized full-length spike protein of the SARS-CoV-2 virus. Phase 1 and 2a clinical trials of CVnCoV began in
June and September 2020, respectively. Phase 1 interim data reported in November 2020 showed that CVnCoV was generally well tolerated
across all tested doses and induced strong antibody responses in addition to first indication of T cell activation. The quality
of immune response was comparable to recovered COVID-19 patients, mimicking the immune response after natural COVID-19 infection.
The data support CureVac's decision to advance a 12 g dose in its upcoming pivotal Phase 2b/3 study, which CureVac
plans to initiate before the end of 2020. Clinical trial material is provided by the company's substantial production capacities
for mRNA vaccines at its headquarters in T bingen, supported by the current expansion of manufacturing capacities to allow
for broad-scale manufacturing of CVnCoV for potential commercial supply preparedness.
CureVac is a global clinical-stage
biopharmaceutical company in the field of messenger RNA (mRNA) technology, with more than 20 years of expertise in developing and
optimizing the versatile biological molecule for medical purposes. The principle of CureVac's proprietary technology is the use
of non-chemically modified mRNA as a data carrier to instruct the human body to produce its own proteins capable of fighting a
broad range of diseases. Based on its proprietary technology, the company has built a deep clinical pipeline across the areas of
prophylactic vaccines, cancer therapies, antibody therapies, and the treatment of rare diseases. CureVac had its initial public
offering on the New York Nasdaq in August 2020. It is headquartered in T bingen, Germany, and employs more than 500 people
at its sites in T bingen, Frankfurt, and Boston, USA. Further information can be found at www.curevac.com.
Fareva, a family-owned company whose
strength lies in its financial independence, is one of the world's leading CDMOs in the pharmaceuticals, cosmetics, make-up,
and industrial and homecare fields. Fareva operates in 11 countries with 39 factories and has more than 12,000 employees with annual
revenue reaching 1.8 billion in 2019. For further information, please come and visit us at www.fareva.com.
CureVac Media Contact
Vice President Communications
T: +49 7071 9883-1577
CureVac Investor Relations
Dr. Sarah Fakih, Vice President
CureVac, T bingen, Germany
T: +49 7071 9883-1298
M: +49 160 90 496949
Media Contact Fareva
Sebastien Poncet, Vice President Strategic Licensing
Marie Wicart, Communication Director
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trials, the timing, expense and uncertainty of regulatory approval, reliance on third parties and collaboration partners, ability
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and governmental policies, pressures from increasing competition and consolidation in the company's industry, the effects
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