CytoSorbents' Pivotal STAR-T Trial Reaches Second Key Milestone With 80 Patients Enrolled PRINCETON, N.J.

CytoSorbents' Pivotal STAR-T Trial Reaches

Second Key Milestone With 80 Patients Enrolled

PRINCETON, N.J., April 20, 2023 - CytoSorbents

Corporation (NASDAQ: CTSO), a leader in the treatment of life-threatening conditions in the intensive care unit and cardiac surgery

using blood purification via its proprietary polymer adsorption technology, announces that its

pivotal STAR-T (Safe and Timely Antithrombotic Removal - Ticagrelor) randomized, controlled

trial has enrolled 80 patients, achieving the second of three key enrollment milestones, and triggering a pre-specified Data and Safety

Monitoring Board (DSMB) safety review.

Dr. Efthymios N. Deliargyris, Chief Medical Officer

of CytoSorbents stated, "We are pleased with the solid enrollment pace of the STAR-T trial, now two-thirds enrolled, and believe

it reflects a) the positive enthusiasm and commitment of participating U.S. and Canadian study centers, b) the large unmet medical need

and numbers of patients on ticagrelor undergoing cardiothoracic surgery, and c) the laser focus of our clinical team. We expect completion

of the second DSMB safety review over the next several months."

Dr. Deliargyris continued, "Because of the

brisk enrollment of the trial, we continue to project that STAR-T will be fully enrolled this summer. Because of this, as we discussed

in our last earnings call in March, we have elected to forego an interim analysis at this stage which would have otherwise taken several

months to conclude, and instead race to complete trial enrollment on schedule and initiate the final study analysis, while preserving

the full statistical power of the study. This would put us in the position of having top-line data later this year, with the goal of filing

for U.S. FDA and Health Canada regulatory approval thereafter."

The STAR-T trial intends to enroll approximately

120 patients at 30 centers in the U.S. and Canada to evaluate whether intraoperative use of DrugSorb -ATR can reduce the

high perioperative risk of bleeding in patients undergoing cardiothoracic surgery who have recently received the blood thinning agent,

ticagrelor. This pivotal study is intended to support U.S. FDA and Health Canada marketing approval for DrugSorb-ATR in this application,

for which CytoSorbents received FDA Breakthrough Device Designation in April 2020, recognizing it as a major unmet medical need

for which there are no FDA-approved or cleared therapies.

About CytoSorbents Corporation

CytoSorbents Corporation is a leader in

the treatment of life-threatening conditions in the intensive care unit and in cardiac surgery through blood purification. Its lead product,

CytoSorb , is approved in the European Union and distributed in 75 countries worldwide. It is an extracorporeal

cytokine adsorber that reduces "cytokine storm" or "cytokine release syndrome" in common critical illnesses that

can lead to massive inflammation, organ failure and patient death. In these diseases, the risk of death can be extremely high, and there

are few, if any, effective treatments. CytoSorb is also used during and after cardiothoracic surgery to remove antithrombotic drugs and

inflammatory mediators that can lead to postoperative complications, including severe bleeding and multiple organ failure. At the end

of 2022, more than 195,000 CytoSorb devices have been used cumulatively. CytoSorb was originally launched in the European Union under

CE mark as the first cytokine adsorber. Additional CE mark extensions were granted for bilirubin and myoglobin removal in clinical conditions

such as liver disease and trauma, respectively, and for ticagrelor and rivaroxaban removal in cardiothoracic surgery procedures.

CytoSorb has also received FDA Emergency Use Authorization in the United States for use in adult critically ill COVID-19 patients

with impending or confirmed respiratory failure. The DrugSorb -ATR antithrombotic removal system, based on the same polymer technology

as CytoSorb, also received two FDA Breakthrough Device Designations, one for the removal of ticagrelor and another for

the removal of the direct oral anticoagulants (DOAC) apixaban and rivaroxaban in a cardiopulmonary bypass circuit during urgent

cardiothoracic procedures. The Company is currently conducting the FDA-approved, randomized, controlled STAR-T (Safe and Timely Antithrombotic

Removal-Ticagrelor) study of 120 patients at approximately 30 centers in U.S. and Canada to evaluate whether intraoperative use of DrugSorb-ATR

can reduce the perioperative risk of bleeding in patients receiving ticagrelor and undergoing cardiothoracic surgery. This pivotal study

is intended to support U.S. FDA and Health Canada marketing approval for DrugSorb-ATR in this application.

CytoSorbents' purification technologies

are based on biocompatible, highly porous polymer beads that can actively remove toxic substances from blood and other bodily fluids

by pore capture and surface adsorption. Its technologies have received non-dilutive grant, contract, and other funding of approximately

$48 million from DARPA, the U.S. Department of Health and Human Services (HHS), the National Institutes of Health (NIH), National

Heart, Lung, and Blood Institute (NHLBI), the U.S. Army, the U.S. Air Force, U.S. Special Operations Command (SOCOM), Air Force Material

Command (USAF/AFMC), and others. The Company has numerous marketed products and products under development based upon this unique

blood purification technology protected by many issued U.S. and international patents and registered trademarks, and multiple patent

applications pending, including ECOS-300CY , CytoSorb-XL , HemoDefend-RBC , HemoDefend-BGA , VetResQ ,

K+ontrol , DrugSorb , DrugSorb -ATR, ContrastSorb, and others. For more information, please visit

Forward-Looking Statements

release includes forward-looking statements intended to qualify for the safe harbor from liability established by the Private Securities

Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, statements about our plans, objectives,

future targets and outlooks for our business, , statements about potential exposures resulting from our cash positions, representations

and contentions, and are not historical facts and typically are identified by use of terms such as "may," "should,"

"could," "expect," "plan," "anticipate," "believe," "estimate,"

"predict," "potential," "continue" and similar words, although some forward-looking statements are

expressed differently. You should be aware that the forward-looking statements in this press release represent management's current

judgment and expectations, but our actual results, events and performance could differ materially from those in the forward-looking statements.

Factors which could cause or contribute to such differences include, but are not limited to, the risks discussed in our Annual Report

on Form 10-K, filed with the SEC on March 9, 2023, as updated by the risks reported in our Quarterly Reports on Form 10-Q, and in

the press releases and other communications to shareholders issued by us from time to time which attempt to advise interested parties

of the risks and factors which may affect our business. We caution you not to place undue reliance upon any such forward-looking statements.

We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future

events, or otherwise, other than as required under the Federal securities laws.

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