CytoSorbents Announces Pivotal STAR-T Trial Reaches First Milestone With 40 Patients Enrolled PRINCETON, N.J.

CytoSorbents Announces Pivotal STAR-T Trial

Reaches First Milestone With 40 Patients Enrolled

PRINCETON, N.J., November 14, 2022 - CytoSorbents

Corporation (NASDAQ: CTSO), a leader in the treatment of life-threatening conditions in the intensive care unit and cardiac surgery

using blood purification via its proprietary polymer adsorption technology, announced that 40 of

the targeted 120 patients have been enrolled in the Safe and Timely Antithrombotic Removal - Ticagrelor

(STAR-T) trial, achieving the first enrollment milestone and triggering a pre-specified Data and Safety Monitoring Board (DSMB)

review. This pivotal study intends to support both U.S. FDA and Health Canada marketing approval of DrugSorb-ATR in the United

States and Canada, respectively, to remove the anti-thrombotic agent, ticagrelor (Brilinta , AstraZeneca), during cardiothoracic surgery.

Dr. Michael J. Mack, Director of the Cardiovascular

Service line at Baylor Scott & White Health System, Chairman of the Baylor Plano Research Center in Texas and co-Principal Investigator

of the STAR-T trial commented: "Reaching our first trial enrollment milestone of 40 patients is a critical first step in the execution

of the landmark STAR-T trial. Currently, cardiac surgeons are either forced to delay life-saving heart surgery in patients who are on

antithrombotic drugs or proceed to operation when they are at very high risk for bleeding. The DrugSorb-ATR device is a novel approach

that could potentially allow these high-risk surgeries to proceed in a safe and timely manner. We have designed two rigorous, pivotal

trials to test the efficacy and safety of this novel device that if successful could make it available to all U.S. cardiac surgeons, so

they can join their international colleagues who have it available and use it routinely in their everyday practice. We are currently focused

on bringing the STAR-T trial across the finish line, so we can then turn our attention to STAR-D. I'd like to thank all of the participating

centers and investigators for helping us reach this first crucial enrollment milestone and we remain very excited to welcome our Canadian

colleagues who should begin contributing to enrollment very soon."

Dr. Efthymios N. Deliargyris, Chief Medical Officer

of CytoSorbents stated, "We are pleased to have enrolled a third of our STAR-T pivotal study, which now triggers the first safety

review by the independent DSMB of the study. We are now working diligently to complete the necessary operational steps including data

collection and validation to support the upcoming DSMB safety review which is estimated in approximately 2 months. With our full attention

and resources now dedicated to STAR-T and the upcoming addition of Canadian sites, we anticipate the momentum to continue and project

that we can achieve the next study milestone of 80 patients enrolled in Spring 2023 that will trigger the next DSMB safety review and

the pre-specified interim analysis.

About CytoSorbents Corporation (NASDAQ: CTSO)

CytoSorbents Corporation is a leader in the treatment

of life-threatening conditions in the intensive care unit and in cardiac surgery through blood purification. Its lead product, CytoSorb ,

is approved in the European Union and distributed in 75 countries worldwide. It is an extracorporeal cytokine adsorber that reduces "cytokine

storm" or "cytokine release syndrome" in common critical illnesses that can lead to massive inflammation, organ failure

and patient death. In these diseases, the risk of death can be extremely high, and there are few, if any, effective treatments. CytoSorb

is also used during and after cardiothoracic surgery to remove inflammatory mediators that can lead to postoperative complications, including

multiple organ failure. As of September 30, 2022, more than 186,000 CytoSorb devices have been used cumulatively. CytoSorb was originally

launched in the European Union under CE mark as the first cytokine adsorber. Additional CE mark extensions were granted for bilirubin

and myoglobin removal in clinical conditions such as liver disease and trauma, respectively, and for ticagrelor and rivaroxaban removal

in cardiothoracic surgery procedures. CytoSorb has also received FDA Emergency Use Authorization in the United States for use in adult

critically ill COVID-19 patients with impending or confirmed respiratory failure. The DrugSorb -ATR antithrombotic removal system,

based on the same polymer technology as CytoSorb, also received two FDA Breakthrough Device Designations, one for the removal of ticagrelor

and another for the removal of the direct oral anticoagulants (DOAC) apixaban and rivaroxaban in a cardiopulmonary bypass circuit during

urgent cardiothoracic procedures. The Company is currently conducting the FDA-approved, randomized, controlled STAR-T (Safe and Timely

Antithrombotic Removal-Ticagrelor) study of 120 patients at 30 centers to evaluate whether intraoperative use of DrugSorb-ATR can reduce

the perioperative risk of bleeding in patients receiving ticagrelor and undergoing cardiothoracic surgery. This pivotal study intends

to support both U.S. FDA and Health Canada marketing approval of DrugSorb-ATR in the United States and Canada, respectively, for this

application. The STAR-T trial will be followed by the STAR D (Safe and Timely Antithrombotic Removal-Direct Oral Anticoagulants)

pivotal trial evaluating the intraoperative use of DrugSorb-ATR to reduce perioperative bleeding risk in patients undergoing cardiothoracic

surgery and taking direct oral anticoagulants, including apixaban and rivaroxaban.

CytoSorbents' purification technologies

are based on biocompatible, highly porous polymer beads that can actively remove toxic substances from blood and other bodily fluids by

pore capture and surface adsorption. Its technologies have received non-dilutive grant, contract, and other funding of approximately

$48 million from DARPA, the U.S. Department of Health and Human Services (HHS), the National Institutes of Health (NIH), National

Heart, Lung, and Blood Institute (NHLBI), the U.S. Army, the U.S. Air Force, U.S. Special Operations Command (SOCOM), Air Force Material

Command (USAF/AFMC), and others. The Company has numerous marketed products and products under development based upon this unique

blood purification technology protected by many issued U.S. and international patents and registered trademarks, and multiple patent applications

pending, including ECOS-300CY , CytoSorb-XL , HemoDefend-RBC , HemoDefend-BGA , VetResQ , K+ontrol ,

DrugSorb , DrugSorb -ATR, ContrastSorb, and others. For more information, please visit the Company's websites

Forward-Looking Statements

This press release includes forward-looking statements

intended to qualify for the safe harbor from liability established by the Private Securities Litigation Reform Act of 1995. These forward-looking

statements include, but are not limited to, statements about our plans, objectives, future targets and outlooks for our business, expectations

regarding the future impacts of COVID-19 or the ongoing conflict between Russia and the Ukraine, representations and contentions and are

not historical facts and typically are identified by use of terms such as "may," "should," "could," "expect,"

"plan," "anticipate," "believe," "estimate," "predict," "potential," "continue"

and similar words, although some forward-looking statements are expressed differently. You should be aware that the forward-looking statements

in this press release represent management's current judgment and expectations, but our actual results, events and performance could differ

materially from those in the forward-looking statements. Factors which could cause or contribute to such differences include, but are

not limited to, the risks discussed in our Annual Report on Form 10-K, filed with the SEC on March 10, 2022, as updated by the risks reported

in our Quarterly Reports on Form 10-Q, and in the press releases and other communications to shareholders issued by us from time to time

which attempt to advise interested parties of the risks and factors which may affect our business. We caution you not to place undue reliance

upon any such forward-looking statements. We undertake no obligation to publicly update or revise any forward-looking statements, whether

as a result of new information, future events, or otherwise, other than as required under the Federal securities laws.

CytoSorbents Contact:

U.S. Public Relations Contact:

Rubenstein Public Relations

European Company Contact:

Public Relations Europe:

+49 69 13823 ext. 960