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CytomX Therapeutics to Present Preclinical Data for Conditionally Activated Interferon Alpha-2b at the SITC 2023 Annual Meeting

Key Takeaway: CytomX Therapeutics announced the upcoming presentation of preclinical data for CX-801 at the SITC Annual Meeting in San Diego. This data supports the potential efficacy of their conditionally activated cytokine program, particularly in combination with checkpoint blockade. The company aims to file an Investigational New Drug (IND) application for CX-801 by the end of 2023, indicating a positive trajectory for their product development pipeline.

Market Sentiment Analysis

POSITIVE FACTORS

  • CytomX is presenting preclinical data for CX-801, indicating progress in their research.
  • The conditionally activated cytokine program could enhance cancer treatment effectiveness combined with checkpoint blockade.
  • The IND filing for CX-801 is anticipated by the end of 2023, suggesting upcoming advancements.

CONCERNS & RISKS

  • There are known and unknown risks involved with their forward-looking statements.
  • CytomX's clinical trial candidates are in the initial stages, which carries significant uncertainties.
  • The possibility that preclinical research may not result in further product candidates adds an element of risk.

Full Press Release Details

- IND filing for CX-801 anticipated by the end of 2023 -
SOUTH SAN FRANCISCO, Calif., Oct. 30, 2023 (GLOBE NEWSWIRE) -- CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of conditionally activated, localized biologics, today announced that preclinical data supporting CX-801, its conditionally activated cytokine program, will be presented at the Society for Immunotherapy of Cancer (SITC) Annual Meeting in San Diego, California.
Details for the poster presentation are as follows:
Presentation Title: Conditionally activated IFNa induces an inflammatory tumor microenvironment in preclinical models and increases efficacy in combination with checkpoint blockade
Abstract Number: 1064
Session Date and Time: November 4, 2023, 9:00 am - 8:30 pm PT
About CytomX Therapeutics, Inc.
CytomX Therapeutics Forward-Looking Statements
This press release includes forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors that are difficult to predict, may be beyond our control, and may cause the actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied in such statements, including those related to the future potential of partnerships or collaboration agreements. Accordingly, you should not rely on any of these forward-looking statements, including those relating to the potential benefits, safety and efficacy or progress of CytomX’s or any of its collaborative partners’ product candidates, including CX-2051, CX-2029, BMS-986288, CX-904, and CX-801, the potential benefits or applications of CytomX’s Probody platform technology, CytomX’s ability to develop and advance product candidates into and successfully complete clinical trials, including the ongoing and planned clinical trials of BMS-986288, and CX-904, the timing of the commencement of clinical trials or initial and ongoing data availability, and the timing of investigational new drug applications, including for CX-801 and CX-2051, and other development milestones. Risks and uncertainties that contribute to the uncertain nature of the forward-looking statements include: the unproven nature of CytomX’s novel Probody Platform technology; CytomX’s clinical trial product candidates are in the initial stages of clinical development and its other product candidates are currently in preclinical development, and the process by which preclinical and clinical development could potentially lead to an approved product is long and subject to significant risks and uncertainties, including the possibility that the results of preclinical research and early clinical trials may not be predictive of future results; the possibility that CytomX’s clinical trials will not be successful; the possibility that current preclinical research may not result in additional product candidates; CytomX’s dependence on the success of CX-2029, BMS-986288, CX-904, CX-801, and CX-2051; CytomX’s reliance on third parties for the manufacture of the Company’s product candidates; possible regulatory developments in the United States and foreign countries; and the risk that we may incur higher costs than expected for research and development or unexpected costs and expenses. Additional applicable risks and uncertainties include those relating to our preclinical research and development, clinical development, and other risks identified under the heading "Risk Factors" included in CytomX’s Quarterly Report on Form 10-Q filed with the SEC on August 8, 2023. The forward-looking statements contained in this press release are based on information currently available to CytomX and speak only as of the date on which they are made. CytomX does not undertake and specifically disclaims any obligation to update any forward-looking statements, whether as a result of any new information, future events, changed circumstances or otherwise.
Probody is a U.S. registered trademark of CytomX Therapeutics, Inc.
SVP, Finance and Accounting
Direct: (317) 767-4764
Investor and Media Contact:
Stern Investor Relations
__________________________________________
1 Licensed from Immunogen

Frequently Asked Questions

What is CX-801?

CX-801 is CytomX's conditionally activated cytokine program in preclinical development.

When will CX-801's IND filing occur?

The IND filing for CX-801 is expected by the end of 2023.

Where will preclinical data for CX-801 be presented?

Preclinical data supporting CX-801 will be presented at the SITC Annual Meeting.

What is the focus of the SITC presentation?

The presentation focuses on CX-801 enhancing efficacy when combined with checkpoint blockade.

What are the risks mentioned for CytomX's programs?

Risks include uncertainties in clinical trials, potential product failures, and regulatory issues.

Last updated: Oct 30, 2023