Aeterna Zentaris Reports First Quarter 2024 Financial Results - Company ended the quarter with $29.5 million in cash - DETECT-trial recruitment completed; Company continues to expect the completion of the trial in the se

Zentaris Reports First Quarter 2024 Financial Results

ONTARIO, May 14, 2024 - Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZS) ("Aeterna" or the "Company"),

a specialty biopharmaceutical company developing and commercializing a diversified portfolio of pharmaceutical and diagnostic products,

today reported its financial and operating results for the quarter ended March 31, 2024. Mr. Giuliano La Fratta, Chief Financial Officer

of Aeterna commented, "This year remains exciting for Aeterna. Our cash position remains strong and we continue to be on track

to complete both the DETECT-trial and the previously announced merger with Ceapro Inc. ("Ceapro") in the second quarter."

of First Quarter 2024 Financial Results

All amounts are in U.S. dollars.

and cash equivalents

The Company had $29.5 million in cash and cash equivalents at March 31, 2024.

of operations for the three-month period ended March 31, 2024

the three-month period ended March 31, 2024, we reported a net loss of $5.8 million, or $4.74 loss per common share, as compared with

a net loss of $4.3 million, or $3.51 loss per common share (basic) for the three-month period ended March 31, 2023. The $1.5 million

increase in net loss is primarily due to a $2.1 million decrease in revenue combined with a $1.2 million increase in selling, general

and administrative expenses, mostly due to non-recurring expenses incurred for the anticipated merger. This was offset by a $1.4 million

decrease in research and development expenses and a $0.4 million increase in net finance income.

Financial Statements and Management's Discussion and Analysis

reference, the Management's Discussion and Analysis of Financial Condition and Results of Operations for the first quarter 2024,

as well as the Company's consolidated financial statements as of March 31, 2024, will be available on the Company's website

(www.zentaris.com) in the Investors section or at the Company's SEDAR+ and EDGAR profiles at www.sedarplus.ca

and www.sec.gov, respectively.

Macimorelin (Macrilen ; GHRYVELIN )

an oral drug used for the diagnosis of adult growth hormone deficiency (AGHD) is approved for marketing under the brand name GHRYVELIN

in the European Economic Area and Macrilen in the United States. In addition, Aeterna Zentaris is currently conducting

the Phase 3 safety and efficacy study AEZS-130-P02 (the "DETECT-trial") evaluating macimorelin for the diagnosis of childhood-onset

growth hormone deficiency (CGHD).

(Macrilen ; GHRYVELIN ), a ghrelin receptor agonist, is an orally active peptidomimetic molecule that stimulates

the secretion of growth hormone from the pituitary gland. Stimulated growth hormone levels are measured in blood samples taken after

oral administration of macimorelin for the assessment of AGHD. Approval of macimorelin for use in adult was granted by the FDA in 2017

and by the EMEA in 2019, based on Phase III data showing that oral macimorelin provides accuracy comparable to that of standard insulin

tolerance testing (ITT), but has a more favorable safety profile compared to ITT. Oral macimorelin also reduces false positive test results,

helping to avoid unnecessary treatment of patients.

Aeterna Zentaris Inc.

is a specialty biopharmaceutical company developing and commercializing a diversified portfolio of pharmaceutical and diagnostic products

focused on areas of significant unmet medical need. Aeterna's lead product, macimorelin (Macrilen; Ghryvelin), is the first and

only U.S. FDA and European Commission approved oral test indicated for the diagnosis of adult growth hormone deficiency (AGHD). Aeterna

is leveraging the clinical success and compelling safety profile of macimorelin to develop it for the diagnosis of childhood-onset growth

hormone deficiency (CGHD), an area of significant unmet need.

is also dedicated to the development of its therapeutic assets and has established a pre-clinical development pipeline to potentially

address unmet medical needs across a number of indications, including neuromyelitis optica spectrum disorder (NMOSD), Parkinson's disease

(PD), hypoparathyroidism and amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease).

more information, please visit www.zentaris.com and connect with the Company on Twitter, LinkedIn and Facebook.

Forward-Looking Statements

press release contains statements that may constitute forward-looking statements within the meaning of U.S. and Canadian securities legislation

and regulations, and such statements are made pursuant to the safe-harbor provision of the U.S. Securities Litigation Reform Act of 1995.

Forward-looking statements are frequently, but not always, identified by words such as "expects," "aiming", "anticipates,"

"believes," "intends," "potential," "possible," and similar expressions. Such statements,

based as they are on current expectations of management, inherently involve numerous risks, uncertainty and assumptions, known and unknown,

many of which are beyond our control.

statements in this press release include, but are not limited to, those relating to Aeterna's expectations regarding: the strength of

its cash position, the completion of the DETECT-trial, the ability of Aeterna and Ceapro to complete the merger transaction with Ceapro

(the "Transaction") on the terms described herein, or at all, and and the timing of the closing of the Transaction.

statements involve known and unknown risks and uncertainties, and other factors which may cause the actual results, performance or achievements

stated herein to be materially different from any future results, performance or achievements expressed or implied by the forward-looking

information. Such risks and uncertainties include, among others, our reliance on the success of the DETECT clinical trial in the European

Union and U.S. for Macrilen (macimorelin) in CGHD; results from our ongoing or planned pre-clinical studies and our DETECT clinical

trial under development may not be successful or may not support advancing the product further in pre-clinical studies, to human clinical

trials or regulatory approval; our ability to raise capital and obtain financing to continue our currently planned operations; our now

heavy dependence on the success of Macrilen (macimorelin) and related out-licensing arrangements and the continued availability

of funds and resources to successfully commercialize the product; the global instability due to the global pandemic of COVID-19 and the

war in the Ukraine, and their unknown potential effect on our planned operations; our ability to enter into out-licensing, development,

manufacturing, marketing and distribution agreements with other pharmaceutical companies and keep such agreements in effect; our ability

to continue to list our common shares on the NASDAQ; and the availability and timing of required stock exchange, regulatory and other

approvals for the completion of the transaction with Ceapro. Investors should consult our quarterly and annual filings with the Canadian

and U.S. securities commissions for additional information on risks and uncertainties, including those risks discussed under the caption

"Risk Factors" in our Annual Report on Form 20-F, which is available on the Company's EDGAR profile at www.sec.gov.

Given the uncertainties and risk factors, readers are cautioned not to place undue reliance on these forward-looking statements. We disclaim

any obligation to update any such factors or to publicly announce any revisions to any of the forward-looking statements contained herein

to reflect future results, events or developments, unless required to do so by a governmental authority or applicable law.

Concerning the Registration Statement

filed a Registration Statement on Form F-1 (including a prospectus) (File No. 333-277115) (the "Registration Statement")

with the U.S. Securities and Exchange Commission (the "SEC") for the issuance of common share purchase warrants and common

shares issuable upon exercise thereof in connection with the Transaction, but it has not yet become effective. The common share purchase

warrants and common shares issuable upon exercise thereof may not be sold nor may offers to buy them be accepted prior to the time the

Registration Statement becomes effective. Before you invest in any Aeterna common shares, you should read the prospectus in the Registration

Statement and the other documents incorporated by reference therein for more complete information about Aeterna, Ceapro, the Transaction

and the common share purchase warrant offering.

may get copies of the Registration Statement for free by visiting EDGAR on the SEC website at www.sec.gov or at SEDAR+ at www.sedarplus.ca.

Alternatively, you may obtain copies of them by contacting Aeterna's investor contact at the details provided below. Other than

as noted above, none of the securities to be issued pursuant to or in connection with the Transaction have been or will be registered

under the United States Securities Act of 1933, as amended (the "U.S. Securities Act"), or any U.S. state securities laws,

and such securities are anticipated to be issued in reliance on the exemption from the registration requirements of the U.S. Securities

Act provided by Section 3(a)(10) thereof and similar exemptions under applicable state securities laws.

Offer or Solicitation

news release and the information contained herein are not, and do not, constitute an offer to sell any securities or a solicitation of

an offer to buy any securities in the United States or any other state or jurisdiction, nor shall any securities of Aeterna be offered

or sold in any jurisdiction in which such an offer, solicitation or sale would be unlawful. Neither the SEC nor any state securities

commission has approved or disapproved of the transactions described herein or determined if this communication is truthful or complete.

Any representation to the contrary is a criminal offense.

should not construe the contents of this communication as legal, tax, accounting or investment advice or a recommendation. You should

consult your own counsel and tax and financial advisors as to legal and related matters concerning the matters described herein.

securities regulatory authority has either approved or disapproved of the contents of this news release. The Toronto Stock Exchange accepts

no responsibility for the adequacy or accuracy of this release.