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Crinetics Pharmaceuticals to Provide PALSONIFY Business Update and Announce Topline Results from Fourth Cohort of Phase 2 Trial of Atumelnant in Congenital Adrenal Hyperplasia

Key Takeaway: Crinetics Pharmaceuticals will hold a conference call on January 5, 2026, to update on PALSONIFY commercialization and share topline results from the fourth cohort of the Phase 2 trial of atumelnant for congenital adrenal hyperplasia. The company is focused on developing therapies for endocrine diseases, with a strong pipeline including atumelnant and PALSONIFY.
Price reaction · baseline $46.73 (2026-01-02 close) · hit pre-market · 3 other CRNX headline(s) in the window, move may be shared
day 0 close
+3.1%
day 1
-1.7%
day 3
+13.9%

Market Sentiment Analysis

POSITIVE FACTORS

  • Crinetics Pharmaceuticals is advancing its pipeline with promising therapies.
  • The company is hosting a conference call to provide important updates.
  • PALSONIFY is the first oral treatment approved for acromegaly, showcasing innovation.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+30%
120-day peak, hindsight
Typical move
7.2%
average across 7 past catalysts
Cash runway
~38 mo
Minimal dilution risk
Lead asset
68Ga-R10602
Phase 1 · Locoregionally Recurrent Hormone-receptor Positive Breast Cancer

Full Press Release Details

SAN DIEGO, Jan. 04, 2026 (GLOBE NEWSWIRE) --Crinetics Pharmaceuticals, Inc.(Nasdaq: CRNX), today announced that the company will host a conference call and webcast on Monday, January 5, 2026 at 8:30 a.m. ET to provide an update on PALSONIFY™ (paltusotine) commercialization and disclose topline results from the fourth cohort of the Phase 2 trial of atumelnant in congenital adrenal hyperplasia.
Conference Call and Webcast DetailsManagement will hold a live conference call and webcast on Monday, January 5, 2026 at 8:30 a.m. ET. A live question-and-answer session will follow the prepared remarks. To access the live audio-only webcast,click here. The archived webcast will also be accessible on the Events & Presentations page in the Investors section of the Crinetics’ website atwww.crinetics.com/events. To participate, please dial 1-833-470-1428 (domestic) or 1-646-844-6383 (international) and refer to Access Code 640078.
ABOUT CRINETICS PHARMACEUTICALSCrinetics Pharmaceuticals is a global pharmaceutical company committed to transforming the treatment of endocrine diseases and endocrine-related tumors through science rooted in patient needs. Crinetics is focused on discovering, developing, and commercializing novel therapies, with a core expertise in targeting G-protein coupled receptors (GPCRs) with small molecules that have specifically tailored pharmacology and properties.
Crinetics’ lead product, PALSONIFY™ (paltusotine), is the first once-daily, oral treatment approved by the U.S. FDA for the treatment of adults with acromegaly who had an inadequate response to surgery and/or for whom surgery is not an option. Paltusotine is also in clinical development for carcinoid syndrome associated with neuroendocrine tumors. Crinetics’ deep pipeline of 10+ disclosed programs includes late-stage investigational candidate atumelnant, which is currently in development for congenital adrenal hyperplasia and ACTH-dependent Cushing’s syndrome, and CRN09682, a nonpeptide drug conjugate candidate that is being developed to treat SST2 expressing neuroendocrine tumors and other SST2 expressing solid tumors. Additional discovery programs address a variety of endocrine conditions such as neuroendocrine tumors, Graves’ disease (including Graves’ hyperthyroidism and Graves’ orbitopathy, or thyroid eye disease), polycystic kidney disease, hyperparathyroidism, diabetes, obesity, and GPCR-targeted oncology indications.

Investors:Gayathri DiwakarHead of Investor Relationsgdiwakar@crinetics.com(858) 345-6340

Media:Natalie BadilloHead of Corporate Communicationsnbadillo@crinetics.com(858) 345-6075

Frequently Asked Questions

When will Crinetics host the conference call?

Crinetics will host the conference call on January 5, 2026, at 8:30 a.m. ET.

What will be discussed during the conference call?

The call will provide an update on PALSONIFY commercialization and topline results from the Phase 2 trial of atumelnant.

What is PALSONIFY used for?

PALSONIFY is approved for treating adults with acromegaly who have inadequate surgical response.

What is atumelnant being developed for?

Atumelnant is in development for congenital adrenal hyperplasia and ACTH-dependent Cushing’s syndrome.

Last updated: Jan 5, 2026