Coya Therapeutics Announces Proposed Public Offering of Common Stock HOUSTON, TX

Coya Therapeutics Announces Proposed Public Offering of Common Stock

HOUSTON, TX, October 23, 2025 - Coya Therapeutics, Inc. (NASDAQ: COYA) ("Coya" or the "Company"), a clinical-stage biotechnology

company focused on developing biologics that enhance regulatory T cell (Treg) function in patients with neurodegenerative disorders, today announced that it intends to offer and sell shares of its common stock in an underwritten public offering. The

Company also expects to grant the underwriters a 30-day option to purchase up to an additional 15% of the shares of its common stock offered in the proposed public offering at the public offering price per

share, less underwriting discounts and commissions. The proposed public offering is subject to market and other conditions, and there can be no assurance as to whether or when the proposed public offering may be completed, or as to the actual size

or terms of the offering.

The Company intends to use the net proceeds from the proposed public offering for working capital and other general corporate

purposes, including funding its clinical development plan.

Lucid Capital Markets is acting as sole book-running manager for the proposed public offering.

The common stock described above is being offered by the Company pursuant to a shelf registration statement on Form

S-3 (File No. 333-289511), including a base prospectus, previously filed with and subsequently declared effective by the Securities and Exchange Commission (the "SEC") on August 19, 2025.

A preliminary prospectus supplement and the accompanying base prospectus relating to the proposed public offering will be filed with the SEC and will be available on the SEC's website at http://www.sec.gov. A final prospectus supplement

and the accompanying base prospectus describing the terms of the proposed public offering will be filed with the SEC. The proposed public offering will be made only by means of the prospectus supplement and the accompanying base prospectus, as may

be further supplemented by any free writing prospectus and/or pricing supplement that the Company may file with the SEC. Copies of the preliminary prospectus supplement and accompanying base prospectus relating to this proposed public offering may

be obtained at the SEC's website at http://www.sec.gov or by request from Lucid Capital Markets, LLC, 570 Lexington Avenue, 40th Floor, New York, NY 10022.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or

jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Coya Therapeutics, Inc.

Headquartered in Houston,

TX, Coya Therapeutics, Inc. (Nasdaq: COYA) is a clinical-stage biotechnology company developing proprietary treatments focused on the biology and potential therapeutic advantages of regulatory T cells ("Tregs") to target systemic

inflammation and neuroinflammation. Dysfunctional Tregs underlie numerous conditions, including neurodegenerative, metabolic, and autoimmune diseases. This cellular dysfunction may lead to sustained inflammation and oxidative stress resulting in

lack of homeostasis of the immune system.

Coya's investigational product candidate pipeline leverages multiple therapeutic modalities aimed at

restoring the anti-inflammatory and immunomodulatory functions of Tregs. Coya's therapeutic platforms include Treg-enhancing biologics, Treg-derived exosomes, and autologous Treg cell therapy.

For more information about Coya, please visit www.coyatherapeutics.com.

COYA 302 is an investigational and proprietary biologic combination therapy with a dual immunomodulatory mechanism of action intended to enhance the

anti-inflammatory function of regulatory T cells (Tregs) and suppress the inflammation produced by activated monocytes and macrophages. COYA 302 comprises proprietary low dose interleukin-2 (LD IL-2) and CTLA-4 Ig and is being developed for subcutaneous administration for the treatment of patients with ALS. These mechanisms may have additive or synergistic effects.

Coya is currently conducting the ALSTARS Trial, a Phase 2, randomized, multi-center, double-blind, placebo-controlled study to evaluate the efficacy and

safety of COYA 302 for the treatment of ALS (ClinicalTrials.gov Identifier: NCT 07161999).

COYA 302 is an investigational product not yet

approved by the FDA or any other regulatory agency.

Forward Looking Statements

This press release contains forward-looking statements under the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, including

statements regarding Coya's expectations on the timing and completion of the proposed public offering and the anticipated use of proceeds therefrom. The proposed public offering is subject to market and other conditions and there can be no

assurance as to whether or when the proposed public offering may be completed or as to the actual size or terms of the proposed public offering. Forward-looking statements involve known and unknown risks, uncertainties and other factors that could

cause actual results to differ materially, including those risks disclosed under the caption "Risk Factors" in the preliminary prospectus supplement related to the proposed public offering that will be filed with the SEC, the

Company's most recently filed Annual Report on Form 10-K and subsequently filed Quarterly Reports on Form 10-Q. There can be no assurances that we will be able to

complete the proposed public offering on the anticipated terms, or at all. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. These forward-looking statements

speak only as of the date hereof. Coya does not undertake and specifically disclaims any obligation to update or revise such statements to reflect new circumstances or unanticipated events as they occur, except as required by law.