Cocrystal Pharma Reports Third Quarter 2025 Financial Results and Provides Updates on its Antiviral Drug-Development Programs Received FDA IND clearance to evaluate CDI-988 as both norovirus preventive and treatment Expe

Pharma Reports Third Quarter 2025 Financial Results and Provides Updates on its Antiviral Drug-Development Programs

Wash. (November 14, 2025) - Cocrystal Pharma, Inc. (Nasdaq: COCP) ("Cocrystal" or the "Company") reports

financial results for the three and nine months ended September 30, 2025, and provides updates on its antiviral product pipeline, upcoming

milestones and business activities.

expect to begin enrolling participants in the first quarter of 2026 for our norovirus challenge study evaluating CDI-988, our

oral broad-spectrum protease inhibitor," said Sam Lee, Ph.D., President and co-CEO of Cocrystal. "This study will provide

an initial assessment of CDI-988 for both prevention and treatment of norovirus infection. Norovirus is a major cause of acute

gastroenteritis and is highly contagious. It spreads rapidly in enclosed environments such as cruise ships, military bases, nursing homes,

and hospitals. At present, there is no FDA-approved treatment or prevention for norovirus infection.

were honored to receive a Small Business Innovation (SBIR) award from the National Institutes of Health (NIH) to advance our work in

developing a novel, broad-spectrum lead candidate targeting the influenza A/B polymerase complex," added Dr. Lee. "This recognition

further validates the strength of our structure-based drug discovery platform technology and its capability to develop innovative antiviral

therapies for addressing unmet medical needs."

with the non-dilutive SBIR award, we strengthened our balance sheet through two recent at-the-market financings under Nasdaq rules,"

said James Martin, Cocrystal's CFO and co-CEO. "This enhanced cash position supports the continued development of our product

pipeline, including our potentially groundbreaking norovirus program."

September 2025 Cocrystal raised gross proceeds of $4.7 million from a registered direct offering along with a private placement of warrants

that, if fully exercised on a cash basis, will raise an additional $8.3 million. In October 2025, the Company completed a private placement

with directors and management for gross proceeds of $1.03 million with warrants that, if fully exercised on a cash basis, will raise

an additional $1.83 million.

Product Pipeline Overview

harness our revolutionary, structure-based drug discovery platform technology to engineer next-generation, broad-spectrum antivirals

that precisely disrupt viral replication mechanisms. Unlike traditional approaches, our technology identifies compounds that bind to

highly conserved regions of viral enzymes, thereby creating a formidable defense against current viral threats as well as their mutations.

By specifically targeting these evolutionary-constrained viral regions, our drug candidates maintain efficacy even as viruses mutate,

while simultaneously minimizing off-target interactions that typically lead to adverse side effects. This dual advantage represents a

significant breakthrough in antiviral drug development. In addition, our innovative methodology fundamentally transforms the conventional

drug discovery paradigm by eliminating the inefficient, resource-intensive cycles of high-throughput compound screening and prolonged

hit-to-lead optimization. The result is faster identification of promising candidates with superior resistance profiles and safety characteristics.

is a common and highly contagious virus that afflicts people of all ages and causes symptoms of acute gastroenteritis including nausea,

vomiting, stomach pain and diarrhea, as well as fatigue, fever and dehydration. There is currently no effective treatment or effective

vaccine for norovirus, and the ability to curtail outbreaks is limited.

685 million global cases annually and a $60 billion worldwide economic impact, norovirus represents one of healthcare's most

pressing unmet needs. In the U.S., noroviruses are responsible for an estimated 21 million infections annually, including 109,000

hospitalizations, 465,000 emergency department visits and an estimated 900 deaths. The annual burden of norovirus to the U.S. is

estimated at $10.6 billion. Noroviruses are responsible for up to 1.1 million hospitalizations and 218,000 deaths annually in children

in the developing world.

is a major global health threat that may become more challenging to treat due to the emergence of highly pathogenic avian influenza viruses

and resistance to approved influenza antivirals. Currently approved antiviral treatments for influenza are effective but are burdened

with significant viral resistance.

year approximately 1 billion cases of seasonal influenza, 3-5 million severe illnesses and up to 650,000 deaths are reported worldwide.

About 8 percent of the U.S. population gets sick from flu each season. In addition to the

health risk, influenza is responsible for an estimated $10.4 billion in direct medical costs in the U.S. each year.

and Other Coronavirus Program

targeting viral replication enzymes and proteases, we believe it is possible to develop effective treatments for all diseases caused

by coronaviruses including SARS-CoV-2 and its variants, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome

(MERS). CDI-988 showed potent in vitro pan-viral activity against common human coronaviruses, rhinoviruses and respiratory

enteroviruses, as well as against noroviruses. The global COVID-19 therapeutics market is estimated to exceed $16 billion annually

Quarter Financial Results

and development (R&D) expenses for the third quarter of 2025 were $954,000, compared with $3.2 million for the third quarter of 2024,

with the decrease primarily due to the timing of clinical study costs as the trials started in 2024 were winding down in 2025. General

and administrative (G&A) expenses for the third quarter of 2025 were $1.1 million, compared with $1.8 million for the third quarter

of 2024, with the decrease primarily due to a reduction in compensation expense.

loss for the third quarter of 2025 was $2.0 million, or $0.19 per share, compared with a net loss for the third quarter of 2024 of $4.9

million, or $0.49 per share.

Months Financial Results

expenses for the first nine months of 2025 were $3.4 million, compared with $10.5 million for the first nine months of 2024. G&A

expenses for the first nine months of 2025 were $3.1 million, compared with $4.1 million for the first nine months of 2024.

loss for the first nine months of 2025 was $6.4 million, or $0.61 per share, compared with a net loss for the first nine months of 2024

of $14.2 million, or $1.40 per share.

reported unrestricted cash as of September 30, 2025 of $7.7 million, which included $4.7 million in gross proceeds from a registered

direct financing completed in September 2025, compared with $9.9 million as of December 31, 2024. Net cash used in operating activities

for the first nine months of 2025 was $6.5 million, compared with $13.3 million for the first nine months of 2024. The Company had working

capital of $7.3 million and 13.0 million common shares outstanding as of September 30, 2025.

October 2025 Cocrystal was granted an NIH SBIR award for $500,000 and completed a private placement for $1.03 million in gross proceeds.

Cocrystal Pharma, Inc.

Pharma, Inc. is a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics that target the replication

process of influenza viruses, coronaviruses (including SARS-CoV-2), noroviruses and hepatitis C viruses. Cocrystal employs unique structure-based

technologies and Nobel Prize-winning expertise to create viable antiviral drugs. For further information about Cocrystal, please visit

www.cocrystalpharma.com.

Note Regarding Forward-Looking Statements

press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including

statements regarding our plans for the future development of preclinical and clinical product candidates including the potential of our

norovirus product candidates, our plans to initiate a human Phase 1b challenge study for our norovirus product candidate CDI-988

in early 2026, and our plans with regard to continued development of CC-42344, the potential characteristics and benefits of and

market for our product candidates, and potential future capital we may receive from warrant exercises for cash. The words "believe,"

"may," "estimate," "continue," "anticipate," "intend," "should,"

"plan," "could," "target," "potential," "is likely," "will,"

"expect" and similar expressions, as they relate to us, are intended to identify forward-looking statements. We have based

these forward-looking statements largely on our current expectations and projections about future events. Some or all of the events anticipated

by these forward-looking statements may not occur. Important factors that could cause actual results to differ from those in the forward-looking

statements include, but are not limited to, the risks and uncertainties arising from our need for

additional capital to fund our operations and our ability to obtain such capital on favorable terms or at all, inflation, the possibility

of a recession, interest rate increases, imposed and threated tariffs, and geopolitical conflicts including those in Ukraine and Israel

on our Company, our collaboration partners, and on the U.S., UK, Australia and global economies,

including manufacturing and research delays arising from raw materials and labor shortages, supply chain disruptions and other business

interruptions including any adverse impacts on our ability to obtain raw materials for and otherwise proceed with studies as well as

similar problems with our vendors and our current and any future clinical research organization (CROs) and contract manufacturing organizations

(CMOs), the progress and results of the studies including any adverse findings or delays, the ability of us and our CROs to recruit volunteers

for, and to otherwise proceed with, clinical studies, our and our collaboration partners' technology and software performing as

expected, financial difficulties experienced by certain partners, the results of any current and future preclinical and clinical studies,

general risks arising from clinical studies, receipt of regulatory approvals, regulatory changes and any adverse developments which may

arise therefrom, potential mutations in a virus we are targeting that may result in variants that are resistant to a product candidate

we develop, the potential for the development of effective treatments by competitors which could reduce or eliminate a prospective future

market share commercializing any product candidates we may develop in the future, and our ability to meet our future liquidity needs.