Full Press Release Details
Pharma Provides an Update on the Clinical Development of its Novel, Broad-Spectrum Antiviral Investigational Candidates
Wash. (January 4, 2024) - Cocrystal Pharma, Inc. (Nasdaq: COCP) ("Cocrystal" or the "Company") provides
an update on the clinical development of its oral first-in-class pan-norovirus and pan-coronavirus dual protease inhibitor CDI-988 and
its oral PB2 inhibitor CC-42344 for the treatment of pandemic and seasonal influenza A.
CDI-988 and CC-42344 were specifically designed and developed using Cocrystal's unique structure-based
drug discovery technology platform to be effective on a broad range of viruses causing these diseases.
are encouraged that the preliminary data of the ongoing Phase 2a and Phase 1 studies showed CC-42344 and CD-988 were well-tolerated with
favorable safety profiles," said Sam Lee, Ph.D., Cocrystal's President and co-CEO. "We see great promise with both
of these drug candidates as potential effective oral treatments for highly contagious, pandemic viruses, while also providing significant
market opportunities for Cocrystal."
targets a highly conserved region in the active site of the main 3CL protease required for viral RNA replication for pandemic norovirus
and coronaviruses, including SARS-CoV-2. CDI-988 is being evaluated for safety and pharmacokinetics in a randomized, double-blinded,
placebo-controlled Phase 1 study in healthy subjects being conducted in Australia. The Company reports favorable preliminary data from
the single-ascending dose cohorts of the clinical study. Cocrystal expects to report topline results from the Phase 1 study this year.
binds to a highly conserved PB2 site of the influenza A polymerase complex and exhibits a novel mechanism of action that inhibits viral
replication. A randomized, double-blind, placebo-controlled Phase 2a clinical study with CC-42344 is underway in the United Kingdom.
The Company reports favorable tolerability and safety in the first cohort of the Phase 2a influenza A challenge study and expects to
report topline results from the Phase 2a clinical study this year. In 2022 Cocrystal reported favorable safety and tolerability results
in the healthy volunteer Phase 1 study with CC-42344 conducted in Australia.
norovirus is a worldwide public health problem, there are no effective treatments or vaccines. Norovirus afflicts an estimated 685
million people annually at an estimated societal cost of $60 billion. About 200 million
cases are seen among children under 5 years old, leading to an estimated 50,000 child deaths every year, mostly in developing countries,
according to the Centers for Disease Control and Prevention (CDC). CDI-988 in vitro studies showed potent broad-spectrum antiviral
activity against a panel of pandemic GII.4 norovirus proteases, which have caused the majority of norovirus outbreaks worldwide since
2002, and a favorable pharmacokinetic property targeting the gastrointestinal tract.
hospitalizations have recently increased in the U.S. with the new JN.1 variant responsible for about 20% of these cases. Driven
by the anticipated emergence of new COVID-19 variants, the global COVID-19 therapeutics market is estimated to exceed $16 billion
by the end of 2031. The ability of someone with no symptoms to transmit infection to another person has heightened the public
health challenge of COVID-19. CDI-988 exhibited superior in vitro potency against SARS-CoV-2 with activity maintained against
variants of concern. By targeting the viral replication protease, Cocrystal believes it is possible to develop an effective treatment
for all coronaviruses, including COVID-19 and its variants, as well as for Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory
year there are approximately 1 billion cases of seasonal influenza worldwide, with 3-5 million severe illnesses and up to 650,000 deaths,
according to the World Health Organization. On average about 8% of the U.S. population contracts influenza each season. In addition
to the health risk, influenza is responsible for approximately $10.4 billion in direct costs for hospitalizations and outpatient visits
for adults in the U.S. annually.
Cocrystal Pharma, Inc.
Pharma, Inc. is a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics that target the replication
process of influenza viruses, coronaviruses (including SARS-CoV-2) noroviruses and hepatitis C viruses. Cocrystal employs unique structure-based
technologies and Nobel Prize-winning expertise to create first- and best-in-class antiviral drugs. For further information about Cocrystal,
please visit www.cocrystalpharma.com.
Note Regarding Forward-Looking Statements
press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including
statements regarding the promise and potential of the two product candidates, the clinical development of CC-42344 as a product candidate
for oral antiviral inhibitor for the treatment of pandemic and seasonal influenza A and the Phase 2a study for such product candidate,
CC-988 as a product candidate for dual oral antiviral inhibitor for the treatment of coronavirus and norovirus and the Phase 1 study
for such product candidate, the potential efficacy and clinical benefits of, and market for, such product candidates, and the expected
results and topline data from these clinical trials in 2024. The words "believe," "may," "estimate,"
"continue," "anticipate," "intend," "should," "plan," "could,"
"target," "potential," "is likely," "will," "expect" and similar expressions,
as they relate to us, are intended to identify forward-looking statements. We have based these forward-looking statements largely on
our current expectations and projections about future events. Some or all of the events anticipated by these forward-looking statements
may not occur. Important factors that could cause actual results to differ from those in the forward-looking statements include, but
are not limited to, risks relating to our ability to proceed with the studies including recruiting
volunteers and procuring materials for such studies by our clinical research organizations and vendors, and the results of such studies.
Further information on our risk factors is contained in our filings with the SEC, including our Annual Report on Form 10-K for
the year ended December 31, 2022. Any forward-looking statement made by us herein speaks only as of the date on which it is made. Factors
or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of
them. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future developments
or otherwise, except as may be required by law.