Full Press Release Details
Cellectar Biosciences Signs Collaboration
with Avicenna Oncology to Develop New PDCs for Solid Tumors
Madison, Wisc. (August 1,
2017) -- Cellectar Biosciences, Inc. (Nasdaq: CLRB), an oncology-focused, clinical stage biotechnology
company (the "company"), today announces the initiation of a collaboration with Avicenna
Oncology GmbH, a leading precision medicine company based in Basel, Switzerland. The collaboration will focus on the development
of new phospholipid drug conjugates (PDCs) combining Cellectar's patented phospholipid ether delivery platform with Avicenna's
novel cytotoxic payloads (potent anti-cancer small molecules).
"We believe the combination
of our targeted PDC delivery with Avicenna's proprietary payloads has tremendous potential for the development of selective
therapeutics for patients suffering with cancer," said Jim Caruso, president and CEO of Cellectar Biosciences. "This
collaboration further validates the utility of our PDC delivery platform to provide targeted treatment of various resistant cancers,
expands and accelerates our conjugate program research and potentially increases our novel, small molecule PDC pipeline."
Under the terms of the research collaboration,
Avicenna will provide their novel payloads to Cellectar, which will leverage its expertise in chemical conjugation to link the
molecules to its phospholipid ether (PDC platform). Cellectar will oversee the in vitro and in vivo testing of these
molecules alongside an antibody drug conjugate (ADC) with the same payload. Both companies will have the option to advance the
development of any of the newly conjugated molecules (PDCs). Financial terms of the collaboration have not been disclosed.
"There remains a significant
unmet medical need for providing patients with new generations of targeted treatments with improved therapeutic index. Combining
Cellectar's PDC platform with our payloads is a very promising approach that could potentially overcome some of the disadvantages
presently seen with ADCs," said Zaki Sellam, MSc, MBA, founder and CEO of Avicenna Oncology. "In line with our common
vision, we are very excited to combine our collective expertise to potentially provide new treatment options for patients"
About Phospholipid Drug Conjugates (PDCs)
Cellectar's product candidates are built upon its patented
cancer cell-targeting delivery and retention platform of optimized phospholipid ether-drug conjugates (PDCs). The company deliberately
designed its phospholipid ether (PLE) carrier platform to be coupled with a variety of payloads to facilitate both therapeutic
and diagnostic applications. The basis for selective tumor targeting of our PDC compounds lies in the differences between the
plasma membranes of cancer cells compared to those of normal cells. Cancer cell membranes are highly enriched in lipid rafts,
which are glycolipoprotein microdomains of the plasma membrane of cells that contain high concentrations of cholesterol and sphingolipids,
and serve to organize cell surface and intracellular signaling molecules. PDCs have been tested in more than 80 different xenograft
About Cellectar Biosciences, Inc.
Cellectar Biosciences
is developing phospholipid drug conjugates (PDCs) designed to provide cancer targeted delivery of diverse oncologic payloads to
a broad range of cancers and cancer stem cells. Cellectar's PDC platform is based on the company's proprietary phospholipid ether
analogs. These novel small-molecules have demonstrated highly selective uptake and retention in a broad range of cancers. Cellectar's
PDC pipeline includes product candidates for cancer therapy and cancer diagnostic imaging. The company's lead therapeutic PDC,
CLR 131, utilizes iodine-131, a cytotoxic radioisotope, as its payload. CLR 131 has been designated as an orphan drug by the US
FDA and is currently being evaluated in a Phase 1 clinical study in patients with relapsed or refractory multiple myeloma and
a Phase 2 clinical study to assess efficacy in a range of B-cell malignancies. The company is also developing proprietary PDCs
for targeted delivery of chemotherapeutics and has several preclinical stage product candidates, and plans to expand its PDC chemotherapeutic
pipeline through both in-house and collaborative R&D efforts. For more information please visit www.cellectar.com.
About Avicenna Oncology GmbH
Based in Basel, Switzerland,
Avicenna Oncology was founded with the purpose of combining precision medicine with drug conjugates to treat resistant cancers.
Led by an experienced team and funded by serial entrepreneurs, the company builds on its international network of collaborations
and promising programs to overcome the limitations of current chemotherapies and targeted therapeutics for which many cancers
have developed resistance mechanisms. For more information please visit www.avicenna-oncology.com.
This news release contains forward-looking statements. You can
identify these statements by our use of words such as "may," "expect," "believe," "anticipate,"
"intend," "could," "estimate," "continue," "plans," or their negatives or cognates.
These statements are only estimates and predictions and are subject to known and unknown risks and uncertainties that may cause
actual future experience and results to differ materially from the statements made. These statements are based on our current beliefs
and expectations as to such future outcomes. Drug discovery and development involve a high degree of risk. Factors that might cause
such a material difference include, among others, uncertainties related to the ability to raise additional capital, uncertainties
related to the ability to attract and retain partners for our technologies, the identification of lead compounds, the successful
preclinical development thereof, the completion of clinical trials, the FDA review process and other government regulation, our
pharmaceutical collaborators' ability to successfully develop and commercialize drug candidates, competition from other pharmaceutical
companies, product pricing and third-party reimbursement. A complete description of risks and uncertainties related to our business
is contained in our periodic reports filed with the Securities and Exchange Commission including our Form 10-K for the year ended
December 31, 2016 These forward-looking statements are made only as of the date hereof, and we disclaim any obligation to
update any such forward-looking statements.