Full Press Release Details
Cellectar Biosciences
Announces Publication of Findings Demonstrating Efficacy of its Phospholipid Ether Analog Platform in Detecting Colorectal Cancer
MADISON, Wis., October 15, 2014,
- Cellectar Biosciences, Inc. (NASDAQ: CLRB), announced that an article reporting the efficacy of its proprietary phospholipid
ether (PLE) analog agents for the detection, imaging and real-time visualization of colorectal cancer was published in PLOS
ONE, an international, peer-reviewed publication.
Cellectar is developing a novel drug delivery
and retention technology engineered to specifically target and accumulate in malignant tissue. By attaching various agents to this
common structure, the company has built a robust pipeline of both diagnostic and therapeutic agents that seek to detect, treat
or illuminate cancerous tissue.
Recent preclinical and clinical evaluations
assessed the efficacy of two of Cellectar's PLE-based agents to successfully accumulate in and illuminate malignant tissue
in colon cancer, the results of which are detailed in the current edition of PLOS ONE in an article entitled: "Phospholipid
Ether Analogs for the Detection of Colorectal Tumors."
In an animal model of colon cancer, CLR1502,
Cellectar's PLE platform linked to a fluorescent agent that allows for real-time visualization of cancer tissue, was found
to accumulate in intestinal tumors, distinguish malignant from non-malignant tissues and highlight regional lymph node involvement.
The authors speculate that CLR1502 may aid in the resection of colon cancer with adequate margins and in identifying regional lymph
nodes and mesenteric tumor deposits.
The authors also examined data from a Phase
I clinical trial in which a patient with metastatic colon cancer was administered I-131-CLR1404, Cellectar's PLE platform
paired with a radiotherapeutic commonly used to treat thyroid and other cancer types. This data indicated that I-131-CLR1404 accumulated
in human colon cancer metastases. The authors suggest this may highlight the potential value not only of I-131-CLR1404 in colorectal
cancer treatment but also, given the shared core structure, of I-124-CLR1404 as a PET imaging agent for this disease.
"Achieving adequate surgical margins
during resection of the primary tumor and proper identification of regional lymph node involvement is critical to the successful
treatment of colorectal cancer," said Dr. Dustin Deming, assistant professor and medical oncologist at the University of
Wisconsin Carbone Cancer Center. "These data provide evidence that CLR1502 might enhance the ability to properly resect colorectal
cancers through better localization of the primary tumor, use of real-time illumination of tumors as a surgical aid, and improved
lymph node identification."
The full article can be found online at: http://dx.plos.org/10.1371/journal.pone.0109668
About Cellectar Biosciences, Inc.
Cellectar Biosciences is developing agents
to detect, treat and monitor a broad spectrum of cancers. Using a novel phospholipid ether analog (PLE) platform technology as
a targeted delivery and retention vehicle, Cellectar's compounds are designed to be selectively taken up and retained in
cancer cells including cancer stem cells. With the ability to attach both imaging and therapeutic agents to its proprietary delivery
platform, Cellectar has developed a portfolio of product candidates engineered to leverage the unique characteristics of cancer
cells to "find, treat and follow" malignancies in a highly selective way. I-124-CLR1404 is a small-molecule, broad-spectrum,
cancer-targeted PET imaging agent currently being evaluated in a Phase II glioblastoma imaging trial. Additionally, multiple investigator-sponsored
Phase I/II clinical trials are ongoing across 11 solid tumor indications. I-131-CLR1404 is a small-molecule, broad-spectrum, cancer-targeted
molecular radiotherapeutic that delivers cytotoxic radiation directly and selectively to cancer cells including cancer stem cells.
A Phase Ib dose-escalation trial of I-131-CLR1404 in patients with advanced solid tumors was completed in the first quarter of
2014 and results presented at the American Society of Clinical Oncology (ASCO) 2014 Annual Meeting. CLR1502 is a preclinical, cancer-targeted,
non-radioactive optical imaging agent for intraoperative tumor margin illumination and non-invasive tumor imaging. For additional
information please visit www.cellectar.com
Kate McNeil, Vice President of IR, PR & Corporate Communications
Cellectar Biosciences, Inc.
Phone: (347) 204-4226
Email: kmcneil@cellectar.com
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the identification of lead compounds, the successful preclinical development thereof, the completion of clinical trials, the FDA
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