Full Press Release Details
Dr. John Friend as Chief Medical Officer
N.J., July 1, 2020 -- Cellectar Biosciences, Inc. (NASDAQ: CLRB), a clinical-stage biopharmaceutical company focused on
the discovery, development and commercialization of drugs for the treatment of cancer, today announced that it has appointed Dr.
John Friend as chief medical officer, effective immediately.
pleased to welcome John back to Cellectar to oversee CLR 131's late-stage oncology clinical development plans and FDA engagement
for our adult and pediatric programs" said Jim Caruso, president and CEO of Cellectar Biosciences. "John's understanding
and prior involvement with CLR 131 combined with his extensive experience in oncology drug development will prove invaluable to
our overall development program and near-term pivotal study registration strategies."
to Cellectar bringing more than 17 years of global drug development and medical affairs expertise in hematology/oncology as well
as a variety of other therapeutic indications. Most recently, he was chief medical officer of DRGT and prior to his earlier tenure
at Cellectar, Dr. Friend served as Senior Vice President of Research and Development at Helsinn Therapeutics (U.S.), Inc. leading
its research and development, clinical, medical affairs and regulatory affairs divisions. Prior to his time at Helsinn, Dr. Friend
held executive responsibility for clinical research, medical affairs, pharmacovigilance and risk management at various pharmaceutical
companies including Akros Pharma, Actavis, Alpharma, Hospira and Abbott.
"I am excited to rejoin the Cellectar team and to lead the clinical development, global regulatory submission and post-approval
support of CLR 131. The recent results from the company's phase 2a B-cell study demonstrating 40% plus response rates for
relapsed and refractory multiple myeloma and non-hodgkin's lymphomas as well as a 100% response rate to date in Waldenstrom
Macroglobulinemia validates my early belief in CLR 131 and the PDC technology platform. I look forward to working to bring CLR
131 to market for the many cancer patients that may benefit from its treatment."
Dr. Friend completed
his post-graduate residency program in family medicine and subsequently served as Clinical Director and faculty attending physician
at Cabarrus Family Medicine Residency Program in North Carolina. He earned his medical degree from UMDNJ-Robert Wood Johnson Medical
School (now Rutgers, RWJMS) and received his undergraduate degree in Chemistry from Southern Methodist University,
with his hiring, Cellectar has granted to Dr. Friend, effective as of his first day of employment with Cellectar, an option to
purchase 100,000 shares of Cellectar's common stock at an exercise price per share equal to the closing price of Cellectar's
common stock on the grant date as reported by Nasdaq. This grant was approved by the Compensation Committee of Cellectar's
Board of Directors and made as an inducement material to Dr. Friend entering into employment with Cellectar as contemplated by
Nasdaq Listing Rule 5635(c)(4).
which has a 10-year term, vests and becomes exercisable in three equal annual installments beginning on the first anniversary from
the date of Dr. Friend's first day of employment.
this information in accordance with Nasdaq Listing Rule 5635(c)(4).
announced his resignation to pursue other opportunities. "We acknowledge and thank Igor for his contributions to our programs
and wish him the very best in his future endeavors," said Jim Caruso, president and CEO of Cellectar Biosciences.
small-molecule Phospholipid Drug Conjugate designed to provide targeted delivery of iodine-131 (radioisotope) directly to
cancer cells, while limiting exposure to healthy cells unlike many traditional on-market treatment options. CLR 131 is the company's
lead product candidate and is currently being evaluated in a Phase 2 study in B-cell lymphomas, and a Phase 1 dose-escalating clinical
study in pediatric solid tumors and lymphomas. The company recently completed a Phase 1 dose-escalation clinical study in r/r multiple
myeloma. The FDA granted CLR 131 Fast Track Designation for both r/r multiple myeloma and r/r diffuse large b-cell lymphoma and
Orphan Drug Designation (ODD) for the treatment of multiple myeloma, lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia,
neuroblastoma, rhabdomyosarcoma, Ewing's sarcoma and osteosarcoma. CLR 131 was also granted Rare Pediatric Disease Designations
for the treatment of neuroblastoma, rhabdomyosarcoma, Ewing's sarcoma and osteosarcoma. Most recently, the European Commission
granted an ODD for r/r multiple myeloma.
Cellectar Biosciences is focused on the
discovery, development and commercialization of drugs for the treatment of cancer. The company is developing proprietary drugs
independently and through research and development collaborations. The company's core objective is to leverage its proprietary
Phospholipid Drug Conjugate (PDC) delivery platform to develop PDCs that specifically target cancer cells, delivering improved
efficacy and better safety as a result of fewer off-target effects. The company's PDC platform possesses the potential for
the discovery and development of the next-generation of cancer-targeting treatments, and it plans to develop PDCs independently
and through research and development collaborations.
The company's lead PDC therapeutic,
CLR 131, is currently in two clinical studies. The CLOVER-1 Phase 2 study completed the Part A dose-exploration portion, conducted
in relapsed/refractory (r/r) B-cell malignancies, and is now enrolling in the Part B expansion cohorts evaluating a two cycle dosing
regimen that provides approximately 100mCi total body dose of CLR 131 in relapsed/refractory (r/r) multiple myeloma (MM) and lymphoplasmacytic
lymphoma/Waldenstrom's macroglobulinemia (LPL/WM). The data from the Part A portion was announced on February 19, 2020. The
company is also conducting a two-part Phase 1 dose-escalation with expansion arms in pediatric solid tumors and lymphomas.
The company's product pipeline includes
one preclinical PDC chemotherapeutic program (CLR 1900) and multiple partnered PDC assets.
For more information, please visit www.cellectar.com
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Forward-Looking Statement Disclaimer
This news release contains forward-looking
statements. You can identify these statements by our use of words such as "may," "expect," "believe,"
"anticipate," "intend," "could," "estimate," "continue," "plans," or
their negatives or cognates. These statements are only estimates and predictions and are subject to known and unknown risks and
uncertainties that may cause actual future experience and results to differ materially from the statements made. These statements
are based on our current beliefs and expectations as to such future outcomes including our expectations of the impact of the recent
COVID-19 pandemic. Drug discovery and development involve a high degree of risk. Factors that might cause such a material difference
include, among others, uncertainties related to the ability to raise additional capital, uncertainties related to the disruptions
at our sole source supplier of CLR 131, the ability to attract and retain partners for our technologies, the identification of
lead compounds, the successful preclinical development thereof, patient enrollment and the completion of clinical studies, the
FDA review process and other government regulation, our ability to maintain orphan drug designation in the United States for CLR
131, the volatile market for priority review vouchers, our pharmaceutical collaborators' ability to successfully develop and commercialize
drug candidates, competition from other pharmaceutical companies, product pricing and third-party reimbursement. A complete description
of risks and uncertainties related to our business is contained in our periodic reports filed with the Securities and Exchange
Commission including our Form 10-K for the year ended December 31, 2019 and our Form 10-Q for the quarter ended March 31, 2020.
These forward-looking statements are made only as of the date hereof, and we disclaim any obligation to update any such forward-looking
statements. These forward looking statements are made only as of the date hereof, and we disclaim any obligation to update any
such forward-looking statements.