Full Press Release Details
Cellectis' R&D Day Highlights Lasme-cel's
Potential to Address Significant Unmet Need for Patients with r/r B-ALL
o Efficacy: ORR of 68% with lasme-cel Process 2 (n=22), 83% at RP2D (n=12) and 100% in the target Phase 2 population
o Safety: in Phase 1 (n=40), lasme-cel was generally
well-tolerated (including 1 case of grade 2 IEC-HS which resolved)
in patients who achieved MRD-negative CR/CRi, median OS was 14.8 months
o In the target Phase 2 population, CR/CRi rate of 56% with ~80% of patients achieving
o In the target Phase 2 population, 100% patients became
transplant eligible with 78% proceeding to transplant
o Among 11 patients previously treated with all 3 targeted therapies
(inotuzumab, blinatumomab, and CD19 CAR-T), 8 responded and 7 achieved MRD-negative status
o BALLI-01 pivotal Phase 2 in r/r B-ALL
o Potential peak gross sales of up to ~$700 million across the U.S., EU4, UK
New York, NY - October 16, 2025-Cellectis (the "Company") (Euronext Growth: ALCLS-NASDAQ: CLLS), a
clinical-stage biotechnology company using its pioneering gene editing platform to develop life-saving cell and gene therapies, today hosted an R&D Day providing promising clinical data from the Phase 1
BALLI-01 study of lasme-cel (UCART22) for transplant ineligible patients with relapsed/refractory B-cell acute lymphoblastic
leukemia (r/r B-ALL) in the third line or beyond (3L+). The Company unveiled the design of the pivotal Phase 2, its planned registration path for lasme-cel's
initial indication, as well as the commercial opportunity. The event also included panel discussions with global hematology experts on the potential of lasme-cel to address the significant unmet need for
heavily pretreated patients.
"We are encouraged by the Phase 1 results of the BALLI-01 study in a
population that had largely exhausted treatment options and faced a poor prognosis. The depth of response we observed, enabling a high percentage of patients in the study to proceed to transplant, with the potential for durable remission, is
clinically meaningful. We are focused on rapidly advancing our pivotal Phase 2 program and bringing lasme1-cel to patients with this significant unmet need" said Adrian Kilcoyne, MD, MPH,
MBA, Chief Medical Officer of Cellectis.
"Today, Cellectis' has reached a tipping point as we move
lasme-cel into a pivotal Phase 2 trial. The need in refractory or relapsed B-ALL, especially for adult patients for whom every day counts, is significant. Our strategy
is to achieve minimal residual disease-negative (MRD-negative) complete remission to create a window for hematopoietic stem cell transplantation and meaningfully improve overall
survival. Cellectis is pioneering allogeneic CAR-T therapies that aim to be safer, faster, and more scalable and accessible therapy. Lasme-cel is designed to be off-the-shelf, ready when the patient is ready, so it may enable rapid disease control instead of waiting, potentially bringing more patients to the point where transplant
becomes possible" said Andr Choulika, Ph.D., Chief Executive Officer of Cellectis. "That is why an allogeneic CD22 approach is not just another CD19 program, it is potential solution for a broader patient population facing r/r B-ALL."
BALLI-01 Phase 1 Study Evaluating lasme-cel
The Phase 1 of BALLI-01 clinical study was designed to evaluate the safety and clinical activity of lasme-cel in patients with r/r B-ALL.
BALLI-01 trial enrolled 40 patients aged 15-70 years expressing >70% CD22 on leukemic blasts. Subjects were heavily pretreated with a median of 4 prior lines of therapy: 80% of subjects had received
prior blinatumomab, approximately half had received prior inotuzumab and prior CD19 autologous CAR-T therapy.
Lasme-cel was given at escalating dose levels following lymphodepletion with either fludarabine and cyclophosphamide (FC) or FC with alemtuzumab (FCA). The addition of alemtuzumab was implemented to sustain host T-cell and Natural Killer (NK)-cell depletion and to support lasme-cel expansion and persistence.
Phase 1 Safety Data:
The Phase 1 safety data confirm
that lasme-cel was generally well-tolerated, with expectations for CAR-T therapies, with manageable adverse events, including cytokine release syndrome (CRS) and immune
effector cell-associated neurotoxicity syndrome (ICANS).
Phase 1 Activity Data
Phase 1 of BALLI-01 study, 40 transplant ineligible 3L+ patients were dosed with lasme-cel :18 patients were dosed with product manufactured by an external CDMO (Process
1, orP1) and 22 patients were dosed with Cellectis-manufactured product (Process 2, or P2). In this dataset, P2 was associated with higher response rate than P1:
Complete Remission (CR) / Complete Remission with complete hematologic Recovery (CRi) rate: 18% for P1 vs 36% for P2.
Lasme-cel is not a commercialized,
FDA-approved product.
At Dose Level 3 P2 (DL3), the recommended Phase 2 dose (RP2D), 12 patients were dosed (n=12):
For the subset of 9 patients who met the criteria of the pivotal Phase 2
population (Process 2, DL3, age 50):
In patients treated with P2, 13 patients had relapsed after prior CD22 targeted therapy (Inotuzumab). Of these 13 patients, 4 (31%) achieved CR/CRi with MRD-negative status and all 4 achieved hematopoietic stem cell transplantation (HSCT). In the overall P2 cohort, the ORR was 69% with MRD-negativity in 83% of responders.
At the RP2D (DL3) subset, 7 of these 12 patients had prior inotuzumab exposure with 43% achieving MRD-negative CR/CRi,
and all of these achieved HSCT.
In the P2 cohort, 11 of 22 patients received 3 prior targeted therapies-CD19
CAR-T, blinatumumab and inotuzumab. Among these heavily pretreated patients, 36% achieved CR/CRi with MRD-negative status.
The survival curve for this study suggests a clear benefit: patients who proceeded to HSCT after lasme-cel therapy
showed a trend to longer overall survival than those who did not undergo transplant.
The Phase 1 data showed that
lasme-cel maintained its efficacy regardless of the number or type of previous treatments, including CAR-T (60% of subjects), transplant (50% of patients), and
blinatumomab (80% of subjects).
Taken together, these findings position lasme-cel as a potentially game-changing
therapy for patients with r/r B-ALL.
Following successful End-of-Phase 1 meetings with the U.S Food and Drug Administration (FDA) and the European Medicines Agency (EMA), Cellectis provided a registration path for lasme-cel as
a bridge to transplant in r/r ALL. The first patient in pivotal Phase 2 is expected to be enrolled in Q4 2025. Cellectis anticipates submitting a Biologics License Application (BLA) in 2028.
Cellectis' R&D Day also included a panel discussion on the potential of lasme-cel to address the significant
unmet need for r/r B-ALL patients. Panelists included:
Pr. Nitin Jain, Professor of
Medicine Department of Leukemia at MD Anderson Cancer Center
Pr. Nicolas Boissel, Head of the Adolescents and Young Adults Unit of the Hematology
Department of H pital Saint-Louis AP-HP
Dr. Aravind Ramakrishnan,
Leading Oncologist and Program medical Director for the Sarah Cannon Transplant & Cellular Therapy Program
Commercial Opportunity for Lasme-cel
As part of the R&D Day presentation, the Company discussed the potential commercial opportunity for lasme-cel in r/r B-ALL.
If approved for commercialization, Cellectis estimates
that lasme-cel has the potential to reach up to approximately 1,900 addressable 3L+ B-ALL patients annually in 2035 across the U.S., EU4 (Germany, France, Spain, Italy)
and UK. Of the projected incident 1L treated B-ALL population of approximately 9,200 patients, about 45% are expected to progress to 2L (mostly adolescents and adults given better outcomes for children) and two-thirds of patients treated in the 2L setting are expected to go on to require further therapeutic intervention. Finally, approximately 70% of patients treated in the 3L setting are considered for clinical
allogeneic CAR-T eligibility based on patient fitness and comorbidities.
Lasme-cel is positioned to potentially capture a majority of such addressable market given that it provides an
alternative target to CD19, one-time dosing, off-the-shelf availability and deep,
MRD-responses in the 3L+ setting. Interviewed physician key opinion leaders indicated an expectation to use lasme-cel in a majority of 3L+ patients if available, and
oncology analogs suggest an illustrative lasme-cel preference share of about 65% among eligible patients.
Finally, lasme-cel has high pricing potential across the U.S., EU4 and UK. For the EU4 and UK, Cellectis triangulated
an illustrative lasme-cel 2025 anchor price of approximately $365,000 from the averaged CAR-T price range, with a projected list price in 2035 assumed to remain constant
with 2025. For the U.S., Cellectis triangulated an illustrative lasme-cel 2025 anchor price of approximately $515,000 from the averaged CAR-T price range, with a
projected 2035 list price, assumed to grow at a ~5% CAGR (Compound Annual Growth Rate) based on the 2021-2025 price growth.2
With the above assumptions, lasme-cel could achieve up to approximately $700 million in potential peak gross
sales across the U.S., EU4 and UK in 2035, corresponding to an estimation of about 1,100 patients treated annually. Furthermore, gross peak sales could increase to up to approximately $1.3 billion with potential label expansion to second line
and first line MRD+ consolidation. These estimates highlight that lasme-cel has the potential to drive meaningful growth of the CAR-T market in B-ALL, leading to a robust peak sales potential with highly attractive margins stemming from the allogeneic approach.
NatHaLi-01 study evaluating eti-cel (UCART20x22)
Cellectis unveiled preliminary data on eti-cel, its allogeneic CAR-T product
candidate for relapsed or refractory non-Hodgkin lymphora (r/r NHL). These preliminary results demonstrate an encouraging overall response rate (ORR) of 86% and a complete response (CR) rate of 57% at the
current dose level (n=7), with 4 out of 7 patients achieving a complete response.
The preliminary high rate of complete responses underscores the potential of this innovative approach to
transform outcomes for r/r NHL patients. Further updates on the program are expected at the end of the year 2025.
Strategic Partnership with
In its presentation during the R&D Day, AstraZeneca highlighted the significance of its strategic investment and research
collaboration with Cellectis to accelerate its cell therapy and genomic medicine ambitions. The collaboration leverages Cellectis' gene editing expertise and manufacturing capabilities to develop up to 10 novel cell and gene therapy products
for areas of high unmet medical need, including oncology, immunology and rare genetic disorders.
A replay of today's event and copy of the presentation will be published on Cellectis' website.
Cellectis is a clinical-stage
biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies. The company utilizes an allogeneic approach for CAR T immunotherapies in oncology, pioneering the concept of off-the-shelf and ready-to-use gene-edited CAR T-cells
to treat cancer patients, and a platform to develop gene therapies in other therapeutic indications. With its in-house manufacturing capabilities, Cellectis is one of the few end-to-end gene editing companies that controls the cell and gene therapy value chain from start to finish.
Cellectis' headquarters are in Paris, France, with locations in New York and Raleigh, NC. Cellectis is listed on the Nasdaq Global Market (ticker: CLLS)