CollPlant Holdings Ltd. 3 Sapir Street, Weizmann Science Park Ness-Ziona Israel NOTICE OF EXTRAORDINARY GENERAL MEETINGS OF SHAREHOLDERS AND HOLDERS OF SERIES I WARRANTS AND SERIES K WARRANTS To Be Held on

CollPlant Holdings Ltd.

3 Sapir Street, Weizmann Science Park

NOTICE OF EXTRAORDINARY GENERAL MEETINGS

OF SHAREHOLDERS AND HOLDERS OF

SERIES I WARRANTS AND SERIES K WARRANTS

To Be Held on June 7, 2018

Notice is hereby given

that three separate extraordinary general meetings (the "Meetings") of shareholders of Collplant Holdings Ltd. (the

"Company"), of holders of Series I Warrants (the "Series I Warrants") and holders of Series K Warrants

(the "Series K Warrants", and together with the Series I Warrants, the "Warrants") of the Company, will

be held at the offices of Gross, Kleinhendler, Hodak, Halevy, Greenberg & Co. law firm, at One Azrieli Center, Round Building,

40th Floor, Tel-Aviv, Israel, with (i) the meeting of the Company's shareholders to be held at 10:00 a.m. Israel time; (ii) the

meeting of holders of Series I Warrants to be held at 10:30 a.m. Israel time; and (iii) the meeting of holders of Series K Warrants

to be held at 11:00 a.m. Israel time, or at any adjournment.

Information on the Meeting of the

Company's Shareholders and ADS Holders

Company's shareholders (including ADS holders) (the "Shareholders' Meeting") is being called for the following

To approve an arrangement between the Company, its shareholders and the holders of Series I Warrants and Series K Warrants

for the delisting of all of the Company's securities from trading on the Tel Aviv Stock Exchange Ltd. ("TASE")

pursuant to Section 350 of the Israeli Companies Law of 1999 (the "Companies Law"); and

To approve an issuance of a pre-paid warrant to purchase ADSs of the Company to Alpha Capital Anstalt.

and ADSs holders of record at the close of business on May 8, 2018 are entitled to notice of and to vote at the Shareholders'

Meeting on Proposals No.1 and No.2.

Information on the Meetings of the

Company's Holders of Warrants

of the meetings of the Company's holders of Series I Warrants and holders of Series K Warrants (the "Warrant Holders'

Meeting") is being called to approve an arrangement between the Company, its shareholders (including ADS holders) and the

holders of Series I Warrants and Series K Warrants for the delisting of all of the Company's securities from trading on the TASE

pursuant to Section 350 of the Companies Law.

The holders of Series

I Warrants and holders of Series K Warrants as of record at the close of business on May 28, 2018 are entitled to notice of and

to vote at the applicable Warrant Holders' Meeting on Proposal No.1 only.

The board of directors

recommends the Company's shareholders and holders of Series I and Series K Warrants to vote in favor of all of the proposals on

the agenda of the Meetings, which are described in the attached Proxy Statement.

CollPlant Holdings Ltd.

3 Sapir Street, Weizmann Science Park

FOR EXTRAORDINARY GENERAL MEETINGS OF

SHAREHOLDERS AND HOLDERS OF

SERIES I WARRANTS AND SERIES K WARRANTS

is being solicited by the board of directors of Collplant Holdings Ltd. (the "Company") for use at the Company's

three separate extraordinary general meetings of the Company's shareholders and of holders of Series I Warrants (the "Series

I Warrants") and Series K Warrants (the "Series K Warrants", and together with the Series I Warrants, the "Warrants")

of the Company, to be held on June 7, 2018, at the offices of Gross, Kleinhendler, Hodak, Halevy, Greenberg & Co. law firm,

at One Azrieli Center, Round Building, 40th Floor, Tel-Aviv, Israel, with (i) the meeting of the Company's shareholders to be held

at 10:00 a.m. Israel time; (ii) the meeting of holders of Series I Warrants to be held at 10:30 a.m. Israel time; and (iii) the

meeting of holders of Series K Warrants to be held at 11:00 a.m. Israel time, or at any adjournment (the "Meetings").

Information on the Meeting of the Company's

Shareholders (including ADS Holders)

Company's shareholders (including holders of American Depositary Shares ("ADSs") (the "Shareholders' Meeting")

is being called for the following purposes:

To approve an arrangement between the Company, its shareholders and the holders of Series I Warrants and Series K Warrants

for the delisting of all of the Company's securities from trading on the Tel Aviv Stock Exchange Ltd. ("TASE")

pursuant to Section 350 of the Israeli Companies Law of 1999 (the "Companies Law"); and

To approve an issuance of a pre-paid warrant to purchase ADSs of the Company to Alpha Capital Anstalt.

Board Recommendation

board of directors unanimously recommends that you vote "FOR" the proposals.

and ADSs holders of record at the close of business on May 8, 2018 (the "Shareholders' Record Date"), are entitled

to notice of and to vote at the Shareholders' Meeting on Proposals No.1 and No.2.

of ADSs (whether registered in their name or in "street name") will receive voting instruction cards in order to instruct

their banks, brokers or other nominees on how to vote. Under the terms of the Deposit Agreement between the Company, The Bank of

New York Mellon as depositary, ("BNY Mellon"), and the holders of the

Company's ADSs (the "Deposit Agreement"), BNY Mellon shall endeavor (insofar as is practicable) to vote or cause

to be voted the number of shares represented by ADSs in accordance with the instructions provided by the holders of ADSs to BNY

Mellon. For ADSs that are held in "street name", through a bank, broker or other nominee, the voting process will be

based on the underlying beneficial holder of the ADSs directing the bank, broker or other nominee to arrange for BNY Mellon to

vote the ordinary shares represented by the ADSs in accordance with the beneficial holder's voting instructions. If no instructions

are received by BNY Mellon from any holder of ADSs (whether held directly by a beneficial holder or in "street name")

with respect to any of the shares represented by the ADSs on or before the date established by BNY Mellon for such purpose, BNY

Mellon shall not vote or attempt to vote the shares represented by such ADSs.

registered in the Company's shareholders' register in Israel, and shareholders who hold ordinary shares through members of the

TASE, may vote through the attached proxy card, which also serves as their voting card, by completing, dating, signing and mailing

the proxy to the Company's offices, so that it is received by the Company no later than four hours prior to the scheduled date

of the Shareholders' Meeting. Shareholders registered in the Company's shareholders' register in Israel, and shareholders who hold

ordinary shares through members of the TASE who vote their ordinary shares by proxy card, must also provide the Company with a

copy of their identity card, passport or certification of incorporation, as applicable. Shareholders who hold ordinary shares through

members of the TASE and intend to vote their ordinary shares either in person or by proxy card must also deliver the Company, no

later than four hours prior to the scheduled date of the Meeting, an ownership certificate confirming their ownership of the Company's

ordinary shares on the Shareholders Record Date, which certificate must be approved by a recognized financial institution, as required

by the Israeli Companies Regulations (Proof of Ownership of Shares for Voting at General Meeting) of 2000, as amended. Alternatively,

shareholders who hold ordinary shares through members of the TASE may vote electronically via the electronic voting system of the

Israel Securities Authority up to six hours before the time fixed for the Meeting. You should receive instructions on electronic

voting from the TASE member through which you hold your ordinary shares.

instructions cards are being distributed to shareholders and ADS holders on or about May 5, 2018 and May 14, 2018, respectively.

Certain officers, directors, employees, and agents of the Company, none of whom will receive additional compensation therefor,

may solicit proxies by telephone, emails, or other personal contact. The Company will bear the cost for the solicitation of the

proxies, including postage, printing, and handling, and will reimburse the reasonable expenses of brokerage firms and others for

forwarding material to beneficial owners of shares and ADSs.

Multiple Record Holders or Accounts

You may receive more

than one set of voting materials, including multiple copies of this document and multiple proxy cards or voting instruction cards.

For example, shareholders who hold ADSs in more than one brokerage account will receive a separate voting instruction card for

each brokerage account in which ADSs are held. Shareholders of record whose shares are registered in more than one name will receive

more than one proxy card. You should complete, sign, date and return each proxy card and voting instruction card you receive.

Two or more shareholders

present, personally or by proxy, holding not less than 20% of the outstanding ordinary shares (including ordinary shares represented

by ADSs) shall constitute a quorum for the Shareholders' Meeting. If within half an hour from the time appointed for the Shareholders'

Meeting a quorum is not present, the Shareholders' Meeting shall be adjourned to the same day next week following the day

of the scheduled meeting, at the same time and place, or at such other day, time and place as shall be prescribed by the board