CollPlant Biotechnologies Ltd. 4 Oppenheimer St, Weizmann Science Park Rehovot 7670104, Israel NOTICE OF ANNUAL AND EXTRAORDINARY GENERAL MEETING OF SHAREHOLDERS To be held on Wednesday

CollPlant Biotechnologies Ltd.

4 Oppenheimer St, Weizmann Science Park

Rehovot 7670104, Israel

NOTICE OF ANNUAL AND EXTRAORDINARY GENERAL MEETING

To be held on Wednesday, August 4, 2021

The annual and extraordinary

general meeting of shareholders of CollPlant Biotechnologies Ltd. (the "Company") will be held at the offices of Gross

& Co. at One Azrieli Center, Round Building, 40th Floor, Tel-Aviv, Israel, on Wednesday, August 4, 2021 at 10:00 a.m.

Israel time, or at any adjournment (the "General Meeting"), for the following purposes:

In addition, shareholders

at the General Meeting will have an opportunity to review and ask questions regarding the financial statements and the Board of Directors'

report of the Company for the fiscal year ended December 31, 2020.

The Company is currently

unaware of any other matters that may be raised at the General Meeting. If any other matters are properly raised at the General Meeting,

the persons designated as proxies shall vote according to their own judgment on those matters.

Only holders of record of

ordinary shares, NIS 1.50 par value per share by the close of business on July 1, 2021 (the "Record Date") shall be

entitled to receive notice of and to vote at the General Meeting.

The Board of Directors

recommends that you vote "FOR" each of the proposals.

Whether or not you plan to

attend the General Meeting, it is important that your ordinary shares be represented. Accordingly, holders of ordinary shares (whether

registered in their name or in "street name") will receive voting instruction cards in order to instruct their banks, brokers

or other nominees on how to vote, and they are kindly requested to complete, date, sign and mail the voting instruction card in the envelope

provided at the earliest convenience so that it will be received no later than the date and time indicated on the form of the voting instruction

registered in the Company's shareholders' register may vote in the General Meeting in person or vote through the attached

form of proxy card, which also serves as their voting card, by completing, dating, signing and mailing the proxy card to the Company's

offices so that it is received by the Company no later than August 4, 2021 at 06:00 a.m. Israel time. Shareholders registered in the Company's

shareholders' register in Israel who vote their ordinary shares by proxy must also provide the Company with a copy of their identity

card, passport or certificate of incorporation (as the case may be), and an ownership certificate confirming their ownership of the Company's

ordinary shares on the Record Date. Such certificate must be approved by a recognized financial institution, as required by the Israeli

Companies Regulations (Proof of Ownership of Shares for Voting at General Meeting) of 2000, as amended.

of the voting card and/or the proxy card will not in any way affect a shareholder's right to attend the General Meeting, and any

person has the right to revoke it at any time before the deadline by filing with the Company a written notice of revocation or a duly

executed proxy card and/or voting instruction card bearing a later date.

The Board of Directors

recommends the Company's shareholders vote "FOR" all of the proposals on the agenda of the General Meeting, which are

described in the attached Proxy Statement.

CollPlant Biotechnologies

4 Oppenheimer St, Weizmann Science Park

Rehovot 7670104, Israel

Proxy Statement is furnished to the holders of ordinary shares, NIS 1.50 par value per share, of CollPlant Biotechnologies Ltd. (the

"Company") in connection with the solicitation by the board of directors of the Company (the "Board of Directors")

of proxies for use at the annual and extraordinary general meeting of shareholders (the "General Meeting"), to be

held on Wednesday, August 4, 2021, at 10:00 a.m., Israel time, at the offices of Gross & Co. at One Azrieli Center, Round Building,

40th Floor, Tel-Aviv, Israel, or at any adjournments thereof.

It is proposed at the

General Meeting to adopt the following proposals or to consider the following items:

In addition, shareholders

at the General Meeting will have an opportunity to review and ask questions regarding the financial statements and the Board of Directors'

report of the Company for the fiscal year ended December 31, 2020.

Shareholders may present

proposals for consideration at the General Meeting by submitting their proposals to the Company no later than July 2, 2021.

Board Recommendation

The Board of Directors

recommends that you vote "FOR" each of the proposals on the agenda.

at the close of business on July 1, 2021 (the "Record Date") shall be entitled to receive notice of and to vote at

the General Meeting and any adjournment thereof. At the close of business on June 15, 2021, the Company had outstanding 10,257,879 ordinary

shares, excluding 18,409 ordinary shares in treasury, each of which is entitled to one vote on each of the matters to be presented at

the General Meeting.

registered in the Company's shareholders' register may vote in the General Meeting in person or vote through the attached

form of proxy card, which also serves as their voting card, by completing, dating, signing and mailing the proxy card to the Company's

offices so that it is received by the Company no later than on August 4, 2021, at 06:00 a.m. Israel time. Shareholders registered in the

Company's shareholders' register who vote their ordinary shares by proxy card must also provide the Company with a copy of

their identity card, passport or certificate of incorporation (as the case may be), and an ownership certificate confirming their ownership

of the ordinary shares on the Record Date. Such certificate must be approved by a recognized financial institution, as required by the

Israeli Companies Regulations (Proof of Ownership of Shares for Voting at General Meeting) of 2000, as amended.

who hold their ordinary shares in "street name" meaning in the name of a bank, broker or other record holder, through Computershare,

must either direct the record holder of their ordinary shares how to vote their ordinary shares, or obtain a legal proxy from the record

holder to vote at the General Meeting on behalf of the record holder together with a proof of such record holder with respect to the holding

of the ordinary shares on the record date. You should follow the directions provided by your broker or nominee regarding how to instruct

them to vote your shares.

instructions cards are being distributed to holders of ordinary shares on or about June 6, 2021. Certain officers, directors, employees,

and agents of the Company, none of whom will receive additional compensation therefor, may solicit proxies by telephone, emails, or other

personal contact. The Company will bear the cost for the solicitation of the proxies, including postage, printing, and handling, and will

reimburse the reasonable expenses of brokerage firms and others for forwarding material to beneficial owners of ordinary shares.

Note for Shareholders Voting via Proxy Card

Shareholders who vote their

shares via proxy card may use the form of proxy and the return envelope enclosed. Shares represented by executed and unrevoked proxies

will be voted at the Meeting.

Shareholders may revoke their

proxies at any time before the effective exercise thereof by returning a later-dated proxy card or by voting their ordinary shares in

person at the General Meeting if the shareholders are the record holder of the ordinary shares and can provide evidence of such (i.e.,

a copy of certificate(s) evidencing their ordinary shares). If a shareholder's proxy is not received by the Company by Wednesday,

August 4, 2021, at 06:00 a.m., Israel time, it shall not be valid at the General Meeting. Notwithstanding the aforesaid, each of the chairman

of the General Meeting or the Company's Secretary may, at his or her discretion, accept proxies after such time if he or she so

Multiple Record Holders or Accounts

You may receive more than

one set of voting materials, including multiple copies of this document and multiple proxy cards or voting instruction cards. For example,

shareholders of record whose ordinary shares are registered in more than one name will receive more than one proxy card. You should complete,

sign, date and return each proxy card and voting instruction card you receive.

Two or more shareholders

present, personally or by proxy, holding not less than 20% of the outstanding ordinary shares shall constitute a quorum for the General

Meeting. If within half an hour from the time appointed for the General Meeting a quorum is not present, the General Meeting shall be

adjourned for one week (to the same day, time and place), or at such other day, time and place as shall be prescribed by the Board of

Directors in a notification to the shareholders. If a quorum is not present at the adjourned General Meeting within half an hour from

the time appointed for such adjourned General Meeting, any number of shareholders present personally or by proxy shall be deemed a quorum

and shall be entitled to deliberate and to resolve in respect of the matters for which the General Meeting was convened. Abstentions are

counted as holders present for the purpose of determining a quorum.