CollPlant Biotechnologies Ltd. 4 Oppenheimer St, Weizmann Science Park Rehovot 7670104, Israel NOTICE OF EXTRAORDINARY GENERAL MEETING OF SHAREHOLDERS To be held on

Biotechnologies Ltd.

4 Oppenheimer St, Weizmann Science Park

Rehovot 7670104, Israel

NOTICE OF EXTRAORDINARY GENERAL MEETING

To be held on October 27, 2019

general meeting of shareholders of CollPlant Biotechnologies Ltd. (the "Company") will be held at the offices

of Gross, Kleinhendler, Hodak, Halevy, Greenberg, Shenhav & Co. law firm, at One Azrieli Center, Round Building, 40th

Floor, Tel-Aviv, Israel, on Sunday, October 27, 2019 at 10:00 a.m. Israel time, or at any adjournment (the "General Meeting"),

for the following purposes:

The Company is currently

unaware of any other matters that may be raised at the General Meeting. If any other matters are properly raised at the General

Meeting, the persons designated as proxies shall vote according to their own judgment on those matters.

Only holders of record

of ordinary shares, NIS 1.50 par value per share, and holders of American Depositary Shares ("ADSs"), each representing

one ordinary share, issued by the Bank of New York Mellon ("BNY Mellon") by the close of business on September

27, 2019 (the "Record Date") shall be entitled to receive notice of and to vote at the General Meeting.

The board of directors

recommends that you vote "FOR" each of the proposals.

plan to attend the General Meeting, it is important that your ordinary shares be represented. Accordingly, holders of ADSs (whether

registered in their name or in "street name") will receive voting instruction cards in order to instruct their banks,

brokers or other nominees on how to vote, and they are kindly requested to complete, date, sign and mail the voting instruction

card in the envelope provided at the earliest convenience so that it will be received no later than the date and time indicated

on the form of the voting instruction card.

registered in the Company's shareholders' register in Israel and shareholders who hold ordinary shares through members

of the Tel-Aviv Stock Exchange Ltd. ("TASE"), who did not convert their ordinary shares to ADSs, may vote in the

General Meeting in person or vote through the attached form of proxy card, which also serves as their voting card, by completing,

dating, signing and mailing the proxy card to the Company's offices so that it is received by the Company no later than October

27, 2019, at 06:00 a.m. Israel time. Shareholders registered in the Company's shareholders' register in Israel and

shareholders who hold ordinary shares through members of the TASE and who did not convert their ordinary shares to ADSs, who vote

their ordinary shares by proxy must also provide the Company with a copy of their identity card, passport or certificate of incorporation

(as the case may be), and an ownership certificate confirming their ownership of the Company's ordinary shares on the Record

Date. Such certificate must be approved by a recognized financial institution, as required by the Israeli Companies Regulations

(Proof of Ownership of Shares for Voting at General Meeting) of 2000, as amended.

of the voting card and/or the proxy card will not in any way affect a shareholder's right to attend the General Meeting,

and any person has the right to revoke it at any time before the deadline by filing with the Company (in the case of holders of

ordinary shares) or with BNY Mellon (in the case of holders of ADSs) a written notice of revocation or a duly executed proxy card

and/or voting instruction card bearing a later date.

The board of directors

recommends the Company's shareholders vote "FOR" all of the proposals on the agenda of the General Meeting, which

are described in the attached Proxy Statement.

Biotechnologies Ltd.

4 Oppenheimer St, Weizmann Science Park

Rehovot 7670104, Israel

This Proxy Statement

is furnished to the holders of ordinary shares, NIS 1.50 par value per share, and to holders of American Depository Shares ("ADSs"),

each representing one ordinary share issued by the Bank of New York Mellon ("BNY Mellon"), of CollPlant Biotechnologies

Ltd. (the "Company") in connection with the solicitation by the board of directors of the Company of proxies for

use at the extraordinary general meeting of shareholders (the "General Meeting"), to be held on Sunday, October

27, 2019, at 10:00 a.m., Israel time, at the offices of Gross, Kleinhendler, Hodak, Halevy, Greenberg, Shenhav & Co. law firm,

at One Azrieli Center, Round Building, 40th Floor, Tel-Aviv, Israel, or at any adjournments thereof.

at the General Meeting to adopt the following proposals or to consider the following items:

The Company is currently

unaware of any other matters that may be raised at the General Meeting. If any other matters are properly raised at the General

Meeting, the persons designated as proxies shall vote according to their own judgment on those matters.

present proposals for consideration at the General Meeting by submitting their proposals to the Company no later than October 20,

Board Recommendation

The board of directors

recommends that you vote "FOR" each of the proposals on the agenda.

and ADS holders at the close of business on September 27, 2019 (the "Record Date") shall be entitled to receive

notice of and to vote at the General Meeting. At the close of business on September 15, 2019, the Company had outstanding 3,820,7901

ordinary shares, each of which is entitled to one vote on each of the matters to be presented at the General Meeting.

of ADSs (whether registered in their name or in "street name") will receive voting instruction cards in order to instruct

their banks, brokers or other nominees on how to vote. Under the terms of the Deposit Agreement between the Company, BNY Mellon

as depositary, and the holders of the Company's ADSs, BNY Mellon shall endeavor (insofar as is practicable) to vote or cause

to be voted the number of shares represented by ADSs in accordance with the instructions provided by the holders of ADSs to BNY

Mellon. For ADSs that are held in "street name", through a bank, broker or other nominee, the voting process will be

based on the underlying beneficial holder of the ADSs directing the bank, broker or other nominee to arrange for BNY Mellon to

vote the ordinary shares represented by the ADSs in accordance with the beneficial holder's voting instructions. If no instructions

are received by BNY Mellon from any holder of ADSs (whether held directly by a beneficial holder or in "street name")

with respect to any of the shares represented by the ADSs on or before the date established by BNY Mellon for such purpose, BNY

Mellon shall not vote or attempt to vote the shares represented by such ADSs.

Not including 18,409 ordinary shares in treasury.

registered in the Company's shareholders' register in Israel and shareholders who hold ordinary shares through members

of the Tel-Aviv Stock Exchange (the "TASE"), who did not convert their ordinary shares to ADSs, may vote in the

General Meeting in person or vote through the attached form of proxy card, which also serves as their voting card, by completing,

dating, signing and mailing the proxy card to the Company's offices so that it is received by the Company no later than on

October 27, 2019, at 06:00 a.m. Israel time. Shareholders registered in the Company's shareholders' register in Israel

and shareholders who hold ordinary shares through members of the TASE and who did not convert their ordinary shares to ADSs, who

vote their ordinary shares by proxy card must also provide the Company with a copy of their identity card, passport or certificate

of incorporation (as the case may be), and an ownership certificate confirming their ownership of the ordinary shares on the Record

Date. Such certificate must be approved by a recognized financial institution, as required by the Israeli Companies Regulations

(Proof of Ownership of Shares for Voting at General Meeting) of 2000, as amended.

cards are being distributed to ADS holders on or about October 3, 2019. Certain officers, directors, employees, and agents of the

Company, none of whom will receive additional compensation therefor, may solicit proxies by telephone, emails, or other personal

contact. The Company will bear the cost for the solicitation of the proxies, including postage, printing, and handling, and will

reimburse the reasonable expenses of brokerage firms and others for forwarding material to beneficial owners of shares and ADSs.

Multiple Record Holders or Accounts

You may receive more

than one set of voting materials, including multiple copies of this document and multiple proxy cards or voting instruction cards.

For example, shareholders who hold ADSs in more than one brokerage account will receive a separate voting instruction card for

each brokerage account in which ADSs are held. Shareholders of record whose shares are registered in more than one name will receive

more than one proxy card. You should complete, sign, date and return each proxy card and voting instruction card you receive.

Two or more shareholders

present, personally or by proxy, holding not less than 20% of the outstanding ordinary shares (including ordinary shares represented

by ADSs) shall constitute a quorum for the General Meeting. If within half an hour from the time appointed for the General Meeting

a quorum is not present, the General Meeting shall be adjourned for one week (to the same day, time and place), or at such other

day, time and place as shall be prescribed by the board of directors in a notification to the shareholders. If a quorum is not

present at the adjourned General Meeting within half an hour from the time appointed for such adjourned General Meeting, any number

of shareholders present personally or by proxy shall be deemed a quorum and shall be entitled to deliberate and to resolve in respect