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Compugen to Present a Pooled Analysis of COM701 Phase 1 trials in Platinum Resistant Ovarian Cancer at ESMO 2025

Key Takeaway: Compugen Ltd. announced it will present a pooled analysis of three Phase 1 trials for COM701, targeting platinum resistant ovarian cancer, at ESMO 2025 in Berlin. The analysis will assess COM701's effectiveness both as a monotherapy and in combination therapies among heavily pretreated patients. The presentation, scheduled for October 18, 2025, is expected to provide insights into the drug's potential impact on this challenging form of cancer. Compugen is focused on developing therapeutic strategies through advanced AI technologies.

Market Sentiment Analysis

POSITIVE FACTORS

  • Presentation of pooled analysis could highlight significant efficacy of COM701.
  • Company aims to address a critical need in platinum resistant ovarian cancer treatment.
  • Utilization of AI/ML for drug target discovery reflects innovative capabilities.

Full Press Release Details

HOLON, Israel, July 28, 2025 /PRNewswire/ -- Compugen Ltd. (Nasdaq: CGEN) (TASE: CGEN) a clinical-stage cancer immunotherapy company and a pioneer in predictive computational drug target discovery powered by AI/ML, today announced that it will present a pooled analysis of data from three Phase 1 trials evaluating COM701 as monotherapy and combination therapy in heavily pretreated platinum resistant ovarian cancer patients at ESMO 2025, being held on October 17-21, 2025, in Berlin, Germany.
Title: COM701 in Ovarian Cancer: A Pooled Analysis of 3 Phase 1 Clinical Trials
Speaker: Dr. Oladapo Yeku, Massachusetts General Hospital, Boston, MA, U.S.
Poster presentation number: 1196P
Date of poster presentation: Saturday, October 18; 12:00-12:45 CEST
The poster will be available in the publications section of Compugen's website, www.cgen.com
Compugen is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable predictive AI/ML powered computational discovery platform (Unigen™) to identify new drug targets and biological pathways for developing cancer immunotherapies. Compugen has two proprietary product candidates in Phase 1 development: COM701, a potential first-in-class anti-PVRIG antibody and COM902, a potential best-in-class antibody targeting TIGIT for the treatment of solid tumors. Rilvegostomig, a PD-1/TIGIT bispecific antibody where the TIGIT component is derived from Compugen's clinical stage anti-TIGIT antibody, COM902, is in Phase 3 development by AstraZeneca through a license agreement for the development of bispecific and multispecific antibodies. GS-0321 (previously COM503), a potential first-in-class, high affinity anti-IL-18 binding protein antibody, which is in Phase 1 development is licensed to Gilead. In addition, the Company's therapeutic pipeline of early-stage immuno-oncology programs consists of research programs aiming to address various mechanisms to activate the immune system against cancer. Compugen is headquartered in Israel, with offices in San Francisco, CA. Compugen's shares are listed on Nasdaq and the Tel Aviv Stock Exchange under the ticker symbol CGEN.
Yvonne Naughton, Ph.D.
Vice President, Head of Investor Relations and Corporate Communications
Email: [email protected]
Tel: +1 (628) 241-0071
SOURCE Compugen Ltd.

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Frequently Asked Questions

What is the focus of Compugen's Phase 1 trials?

The trials focus on COM701 for platinum-resistant ovarian cancer patients.

When will the findings be presented at ESMO 2025?

The presentation is scheduled for October 18, 2025, from 12:00-12:45 CEST.

Who will present the COM701 analysis?

Dr. Oladapo Yeku from Massachusetts General Hospital will present.

Where can I find the poster presentation?

The poster will be available on Compugen's website under publications.

What type of therapies is Compugen developing?

Compugen is developing cancer immunotherapies using predictive AI/ML.

Last updated: Jul 28, 2025