Full Press Release Details
Medical Technology Holdings to Expand into 10 Billion Dollar per Year Lower Back Pain Market with Acquisition of Issued US
Stage Stem Cell Company Continues Aggressive Pursuit of Personalized, Rapid to Implement, Autologous Regenerative Medicine
May 18, 2017 Creative Medical Technology
Holdings, Inc. (OTCQB:CELZ) announced today the acquisition of issued US patent #9,598,673 covering use of various stem cells
for treatment of lower back pain through healing of perfusion defects.
The Company believes, based on various
scientific studies, that a large number of patients with lower back pain undergo progression to disc degeneration due to suboptimal
levels of oxygen and nutrients entering the disc. This is believed to be a process similar to what happens in the heart, when
the arteries feeding the heart thicken, resulting in reduced heart function. Thickening of arteries feeding the disc is believed
to result in starving the disc of nutrients and oxygen, resulting in eventual deterioration and pain. Through administration of
stem cells in proximity to the disc, the process is designed to stimulate production of new blood vessels, which will assist the
"Creative Medical Technology
Holdings will develop this patent through the same process that we are using for our clinical-stage Caverstem procedure for erectile
dysfunction," stated Timothy Warbington, President and Chief Executive Officer of the Company. "We plan to identify
and engage key opinion leaders who will lead clinical trials, which will serve as the basis for accelerated commercialization."
The Company is currently running
a clinical trial using autologous non-manipulated bone marrow stem cells for patients suffering from erectile dysfunction that
are non-responsive to standard approaches such as Viagra. Once the trial is completed, the results will serve as the basis for
marketing of disposables utilized in administration of stem cells.
"Although numerous companies
are injecting stem cells directly into the disc, direct injection may only cause temporary benefit because the root cause of the
pathology, in our opinion, is the reduced blood supply," stated Dr. Amit Patel, Director of Thoracic Surgery at University
of Miami and co-founder of Creative Medical Technology Holdings. "By recreating in the microenvironment of the lower back
the same thing that we do in atherosclerotic heart patients, we believe we have a novel way to treat this terrible condition that
wreaks havoc on our health care system."
Several studies have shown that
administration of stem cells possesses a therapeutic effect in cardiac conditions associated with poor circulation by stimulation
of new blood vessel production, a process termed "angiogenesis". The current patent covers stimulation of angiogenesis
in the lower back using mesenchymal stem cells. These cells can be used from the same patient, which is considered an "autologous
therapy" as well as using stem cells in a universal donor manner, which is termed "allogeneic".
"The acquisition of this patent
not only positions the company to expand into the disc degenerative space, but also provides a powerful platform for collaboration
with other companies that are administering regenerative cells directly into the nucleus pulposus of the disc," commented
Thomas Ichim, Ph.D., Chief Scientific Officer of the Company and inventor of the technology. "Stem cells are like seeds,
they need to be planted into fertile soil. We feel that in certain patients it is essential to treat the lumbar ischemia, which
is present in some patients suffering from disc degenerative disease, which will then allow the stem cells administered directly
in the disc to perform their regenerative effects."
Creative Medical Technology Holdings,
Inc. is a clinical-stage biotechnology company with two focus areas; 1) personalized stem cell procedures for sexual dysfunction
and infertility, and 2) universal, off-the-shelf amniotic fluid-based stem cells that possess superior healing potential without
negative medical or ethical issues. Through our own research and collaborations with leading academic institutions, we have developed
proprietary protocols, built an extensive intellectual property portfolio, developed complete treatment offerings for erectile
dysfunction and are performing ground-breaking research with our amniotic fluid-based stem cell.
information visit www.CREATIVEMEDICALTECHNOLOGY.com
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