IsoRay Announces Second Quarter Fiscal 2017 Financial Results Management Continues to Expect Stronger Second Half of Fiscal 2017

Announces Second Quarter Fiscal 2017 Financial Results

Continues to Expect Stronger Second Half of Fiscal 2017

RICHLAND, Wash., February 8, 2017 --

IsoRay, Inc. (NYSE MKT: ISR), a medical technology company and innovator in seed brachytherapy and medical radioisotope applications

for the treatment of prostate, brain, lung, head and neck and gynecological cancers, today announced financial results for the

second quarter of fiscal 2017, ended December 31, 2016.

second quarter of fiscal 2017 was $1.03 million, a 14% decrease compared to $1.19 million revenue for the second quarter of fiscal

2016. The decrease in revenue is primarily due to the continuing maturation of our recently adopted marketing approach and ongoing

training and support for our sales staff following recent changes in personnel. Prostate brachytherapy represented 86% of total

revenue for the second quarter of fiscal 2017 compared to 87% in the second quarter of fiscal 2016. Total operating expenses were

$1.48 million in the second quarter of fiscal 2017, a modest increase compared to $1.44 million posted in the second quarter of

fiscal 2016. Increases in research and development and sales and marketing expenses were offset by a decrease in general and administrative

(G&A) expenses of $0.25 million, or 22%. The G&A decrease is primarily due to lower legal fees as well as the absence of

one-time costs associated with the retirement of the Company's former CEO, which were recorded in the second quarter of fiscal

was $1.48 million, a modest increase compared to an operating loss of $1.41 million for the second quarter of fiscal 2016. The

net loss was $1.45 million, or $(0.03) per basic and diluted share, compared to a net loss of $1.31 million, or $(0.02), per basic

and diluted share, for the same period of fiscal 2016. Basic and diluted per share results are based on weighted average shares

outstanding of approximately 55.0 million shares in both periods. IsoRay had cash, cash equivalents and certificates of deposit

of $11.9 million as of December 31, 2016, and no debt.

yet reflected in our financial results, our newly adopted, focused marketing approach that positions IsoRay and Cesium-131 as a

leader in brachytherapy for prostate cancer treatment is gaining traction, supported by our recently expanded and experienced sales

force. We are continuing to bolster the sales force, and replaced two salespeople in the second quarter. Our sales force now numbers

six, which includes four salespeople that are new to IsoRay. We're also continuing to add content, case studies and other

resources to our recently re-branded website, collateral marketing materials and a recently launched expanded social media presence,

all in our effort to raise awareness of IsoRay and the advantages of Cesium-131. The sales force has become increasingly effective

in delivering IsoRay's renewed message of commitment to prostate brachytherapy, which has been reinforced during follow-up

visits and conversations with senior management, including myself," said Thomas LaVoy, Chairman and CEO.

same time we are continuing to support and pursue opportunities for Cesium-131 as a treatment for cancers in other areas of the

body, including brain, lung, head and neck and gynecological cancers. We believe these areas represent important avenues of potential

revenue growth for the Company. During the second quarter, we announced a poster presentation at the Annual Meeting of the Society

for Neuro-Oncology that was held in November, which details recurrences of high grade glioma which were treated with surgical removal

of the recurrent brain tumor followed by placement of the GammaTile radiation therapy system. The GammaTile system

uses Cesium-131 radiation sources embedded in a collagen carrier and enables very high doses of radiation to be precisely delivered

to targeted tissue. At the time of presentation, the median time to recurrence had clearly been extended from four months previously

for this group of patients, but remained fully undefined due to the majority of patients still experiencing no recurrence at six

months post treatment."

the second quarter, we announced the launch of a pilot study using intraoperative placement of Cesium-131 permanent interstitial

brachytherapy in resectable high risk recurrent head and neck cancer by Case Western Comprehensive Cancer Center, a leader in cancer

research and among the 41 Comprehensive Cancer Centers designated in the U.S. by the National Cancer Institute. The study will

evaluate the impact of Cesium-131 therapy on disease control in recurrent head and neck cancers as well as the safety of the approach

beginning in early 2017. These are just the two latest examples of the research we are supporting in the other areas of the body

that we're focused on," continued Mr. LaVoy.

results do indicate incremental improvement, with the second quarter operating loss nearly flat year-over-year, despite the 14%

decline in revenue. This reflects tight expense control and reallocation of resources toward revenue producing areas such as sales

and marketing and research and development. We are also continuing to invest in the automation of our production processes and

expect to realize lower costs over the next 12 months from these efforts. Looking ahead, we believe that there is increasing market

interest in Cesium-131 and, if revenue levels begin to increase and costs stabilize around current levels, we expect to benefit

from increasing operating leverage. We also continue to expect a stronger second half of fiscal 2017, which began on January 1st,

and are estimating a revenue increase of approximately 20% year-over-year for the remaining six months of fiscal 2017," concluded

six months of fiscal 2017 ended December 31, 2016, revenue was $2.11 million, a 14% decrease compared to revenue of $2.45 million

for the same period of fiscal 2016. Prostate brachytherapy represented 88% of total revenue for the first six months of both fiscal

2017 and fiscal 2016. Operating expenses were $3.10 million, a 19% increase compared to $2.61 million for the six months ended

December 31, 2015. Operating loss was $3.05 million for the six months ended December 31, 2016, compared to a $2.50 million operating

loss for the comparable period of fiscal 2016. The net loss for the six month period was $2.95 million, or $(0.05) per basic and

diluted share, compared to a net loss of $2.31 million, or $(0.04), per basic and diluted share, for the six month period of fiscal

2016. Basic and diluted per share results are based on weighted average shares outstanding of approximately 55.0 million shares

Inc., through its subsidiary, IsoRay Medical, Inc. is the sole producer of Cesium-131 brachytherapy seeds, which are expanding

brachytherapy options throughout the body. Learn more about this innovative Richland, Washington Company and explore the many benefits

Safe Harbor Statement

in this news release about IsoRay's future expectations, including: the advantages of our products and their delivery systems,

whether interest in and use of our products will increase or continue, whether the new marketing strategy will increase sales,

whether the changes to the sales staff will result in increased sales, whether the additional resources being added to IsoRay's

online presence will increase patient or clinician engagement and interest, whether use of Cesium-131 in non-prostate applications

will increase revenue, whether further automation of production processes will be completed or will result in lower costs, whether

revenue will increase by 20% year-over-year for the remaining six months of fiscal 2017, and all other statements in this release,

other than historical facts, are "forward-looking statements" within the meaning of the Private Securities Litigation

Reform Act of 1995 ("PSLRA"). This statement is included for the express purpose of availing IsoRay, Inc. of the protections

of the safe harbor provisions of the PSLRA. It is important to note that actual results and ultimate corporate actions could differ

materially from those in such forward-looking statements based on such factors as physician acceptance, training and use of our

products, our ability to successfully manufacture, market and sell our products, our ability to manufacture our products in sufficient

quantities to meet demand within required delivery time periods while meeting our quality control standards, our ability to enforce

our intellectual property rights, whether additional studies are released and support the conclusions of past studies, whether

ongoing patient results with our products are favorable and in line with the conclusions of clinical studies and initial patient

results, patient results achieved when our products are used for the treatment of cancers and malignant diseases, successful completion

of future research and development activities, whether we, our distributors and our customers will successfully obtain and maintain

all required regulatory approvals and licenses to market, sell and use our products in its various forms, continued compliance

with ISO standards as audited by BSI, the success of our sales and marketing efforts, changes in reimbursement rates, changes in

laws and regulations applicable to our products, the scheduling of physicians who either delay or do not schedule patients in the

six month period that an increase is anticipated, the use of competitors' products in lieu of our products over the six month

period we expect an increase, less favorable reimbursement rates during the six month period we expect an increase, and other risks

detailed from time to time in IsoRay's reports filed with the SEC. Unless required to do so by law, the Company undertakes no obligation

to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Stephanie Prince, Managing Director

IsoRay, Inc. and Subsidiaries

Consolidated Statements of Operations (Unaudited)

(Dollars and shares in thousands, except for per-share amounts)

The accompanying notes are an integral part of these consolidated financial statements.