Full Press Release Details
Capricor Resumes Dosing of Enrolled Patients
in HOPE-2 Clinical Trial for Duchenne Muscular Dystrophy
LOS ANGELES, February 6, 2019 - Capricor
Therapeutics (NASDAQ: CAPR), a clinical-stage biotechnology company, today announced that it has resumed per protocol dosing
of patients already enrolled in its HOPE-2 clinical trial of CAP-1002, the company's novel cell therapy candidate to treat
Duchenne muscular dystrophy. Approximately 20 young men and boys in advanced stages of Duchenne muscular dystrophy have already
been enrolled in the randomized, double-blind, placebo-controlled trial to date.
Capricor had put a voluntary hold on dosing
in December after a patient in the HOPE-2 trial had a serious adverse event in the form of anaphylaxis. The investigation
suggested the patient may have been allergic to something contained in the investigational product, including an excipient, or
inactive ingredient, in the formulation.
To reduce the risk of future events, Capricor
initiated a pre-medication strategy commonly used by physicians to prevent and treat allergic reactions. The U.S. Food and Drug
Administration (FDA) and the Data and Safety Monitoring Board (DSMB) have granted permission to resume enrollment in the HOPE-2
The HOPE-2 trial is studying the safety
and effectiveness of CAP-1002 in older Duchenne patients who are not currently eligible for gene therapy clinical trials. Enrollment
of new patients will depend on various factors but will not commence until additional funding is secured.
To reduce expenses and better align resources and personnel
on the company's core lead programs, Capricor has reduced its staff by 21 full-time employees. The reduction in operating
expenses is expected to extend the company's cash, cash equivalents and marketable securities into late 2019. Additionally,
Capricor is exploring strategic alternatives, with respect to one or more of its product candidates.
About Duchenne Muscular Dystrophy
Duchenne muscular dystrophy is a devastating
genetic disorder that causes muscle degeneration and leads to death, generally before the age of 30, most commonly from heart failure.
It occurs in one in every 3,600 live male births across all races, cultures and countries. Duchenne muscular dystrophy afflicts
approximately 200,000 boys and young men around the world. Treatment options are limited, and there is no cure.
CAP-1002 consists of allogeneic cardiosphere-derived
cells, or CDCs, a type of progenitor cell that has been shown in pre-clinical and clinical studies to exert potent immuno-modulatory
activity, and is being investigated for its potential to modify the immune system's activity to encourage cellular regeneration.
CDCs have been the subject of over 100 peer-reviewed scientific publications and have been administered to approximately 140 human
subjects across several clinical trials.
About Capricor Therapeutics
Capricor Therapeutics, Inc. (NASDAQ:CAPR)
is a clinical-stage biotechnology company focused on the discovery, development and commercialization of first-in-class biological
therapeutics for the treatment of rare disorders. Capricor's lead candidate, CAP-1002, is an allogeneic cell therapy that
is currently in clinical development for the treatment of Duchenne muscular dystrophy. Capricor has also established itself as
one of the leading companies investigating the field of extracellular vesicles and is exploring the potential of CAP-2003, a cell-free,
exosome-based candidate, to treat a variety of disorders. For more information, visit www.capricor.com.
Keep up with Capricor on social media: www.facebook.com/capricortherapeutics,
Cautionary Note Regarding Forward-Looking Statements
Statements in this press release regarding
the efficacy, safety, and intended utilization of Capricor's product candidates; the initiation, conduct, size, timing and results
of discovery efforts and clinical trials; the pace of enrollment of clinical trials; plans regarding regulatory filings, future
research and clinical trials; regulatory developments involving products, including the ability to obtain regulatory approvals
or otherwise bring products to market; plans regarding current and future collaborative activities and the ownership of commercial
rights; scope, duration, validity and enforceability of intellectual property rights; future royalty streams, expectations with
respect to the expected use of proceeds from the recently completed offerings and the anticipated effects of the offerings, and
any other statements about Capricor's management team's future expectations, beliefs, goals, plans or prospects constitute forward-looking
statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not statements of
historical fact (including statements containing the words "believes," "plans," "could," "anticipates,"
"expects," "estimates," "should," "target," "will," "would" and similar
expressions) should also be considered to be forward-looking statements. There are a number of important factors that could cause
actual results or events to differ materially from those indicated by such forward-looking statements. More information about these
and other risks that may impact Capricor's business is set forth in Capricor's Annual Report on Form 10-K for the year ended December
31, 2017 as filed with the Securities and Exchange Commission on March 22, 2018, in its Registration Statement on Form S-3, as
filed with the Securities and Exchange Commission on September 28, 2015, together with the prospectus included therein and prospectus
supplements thereto and in its Quarterly Report on Form 10-Q for the quarter ended September 30, 2018, as filed with the Securities
and Exchange Commission on November 14, 2018. All forward-looking statements in this press release are based on information available
to Capricor as of the date hereof, and Capricor assumes no obligation to update these forward-looking statements.
CAP-1002 is an Investigational New Drug
and is not approved for any indications. CAP-2003 has not yet been approved for clinical investigation.
For more information, please contact:
AJ Bergmann, Chief Financial Officer