Can-Fite BioPharma Ltd. Instructions to The Bank of New York Mellon, as Depositary (Must be received prior to 5:00 p.m. EST on

to The Bank of New York Mellon, as Depositary

be received prior to 5:00 p.m. EST on November 18, 2015)

undersigned registered owner of American Depositary Shares hereby requests and instructs The Bank of New York Mellon, as Depositary,

to endeavor, in so far as practicable, to vote or cause to be voted the amount of Shares or other Deposited Securities represented

by such Shares of Can-Fite BioPharma Ltd. registered in the name of the undersigned on the books of the Depositary as of the close

of business on October 29, 2015 at the Special General Meeting of the Shareholders of Can-Fite BioPharma Ltd. To

be held on November 26, 2015 or any postponement or adjournment thereof in respect of the resolutions specified on the

THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE PROPOSAL AT THE MEETING

(Continued and to be marked, dated and signed, on the other