Can-Fite Announces $10.0 Million Registered Direct Offering

Can-Fite Announces $10.0 Million Registered

PETACH TIKVA, Israel, August

12, 2021 -- Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE:CFBI), a biotechnology company with a pipeline of proprietary small molecule

drugs that bind specifically to the A3 adenosine receptor (A3AR), addressing cancer, liver and inflammatory diseases, today announced

that it has entered into a definitive agreement with a single healthcare-focused institutional investor for the purchase and sale of 5,000,000

of the Company's American Depositary Shares (ADSs) (or ADS equivalents in lieu thereof), at an effective purchase price of $2.00 per

ADS, in a registered direct offering. Can-Fite has also agreed to issue and sell to the investor, in a concurrent private placement,

unregistered warrants to purchase up to an aggregate of 5,000,000 ADSs. Each ADS represents thirty (30) ordinary shares, par

value NIS 0.25 per share, of Can-Fite. The offering is expected to close on or about August 16, 2021, subject to satisfaction

of customary closing conditions.

H.C. Wainwright & Co.

is acting as the exclusive placement agent for the offering.

The warrants will have an exercise price of $2.00 per

ADS and will be exercisable at any time upon issuance and will expire three (3) years following the effectiveness of an initial resale

registration statement registering the ADSs issuable upon the exercise of the warrants.

The gross proceeds from the

offering (without taking into account any proceeds from any future exercises of warrants issued in the concurrent private placement),

before deducting the placement agent's fees and other estimated offering expenses payable by the Company, are expected to be $10.0

million. Can-Fite intends to use the net proceeds for funding research and development and clinical trials and for other working capital

and general corporate purposes.

The ADSs and the ADSs equivalents

(but not the warrants or the ADSs underlying the warrants) are being offered by Can-Fite pursuant to a "shelf" registration

statement on Form F-3 (File No. 333-249063) originally filed with the U.S. Securities and Exchange Commission (the "SEC") on September

25, 2020 and declared effective by the SEC on October 9, 2020. The offering of the ADSs and the ADSs equivalents is being made

only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. A final prospectus

supplement and the accompanying prospectus relating to the ADSs and the ADSs equivalents being offered will be filed with the SEC. Electronic

copies of the final prospectus supplement and the accompanying prospectus may be obtained, when available, on the SEC's website at http://www.sec.gov or

by contacting H.C. Wainwright & Co., LLC at 430 Park Avenue, 3rd Floor, New York, NY 10022, by phone at (212)

856-5711 or e-mail at placements@hcwco.com.

The warrants described above

were offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Act"), and Regulation

D promulgated thereunder and, along with the ADSs underlying the warrants, have not been registered under the Act, or applicable state

securities laws. Accordingly, the warrants and underlying ADSs may not be offered or sold in the United States except pursuant

to an effective registration statement or an applicable exemption from the registration requirements of the Act and such applicable state

This press release shall

not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any jurisdiction

in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any

About Can-Fite BioPharma Ltd.

Can-Fite BioPharma Ltd. (NYSE American: CANF)

(TASE: CFBI) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion

dollar markets in the treatment of cancer, liver, inflammatory disease and COVID-19. The Company's lead drug candidate, Piclidenoson,

is currently in a Phase III trial for psoriasis and a Phase II study in the treatment of moderate COVID-19. Can-Fite's liver drug, Namodenoson,

is headed into a Phase III trial for hepatocellular carcinoma (HCC), the most common form of liver cancer, and a Phase IIb trial for the

treatment of non-alcoholic steatohepatitis (NASH). Namodenoson has been granted Orphan Drug Designation in the U.S. and Europe and Fast

Track Designation as a second line treatment for HCC by the U.S. Food and Drug Administration. Namodenoson has also shown proof of concept

to potentially treat other cancers including colon, prostate, and melanoma. CF602, the Company's third drug candidate, has shown efficacy

in the treatment of erectile dysfunction. These drugs have an excellent safety profile with experience in over 1,500 patients in clinical

studies to date. For more information please visit: www.can-fite.com.

Forward-Looking Statements

This press release may contain forward-looking statements,

about Can-Fite's expectations, beliefs or intentions regarding, among other things, market risks and uncertainties, its product

development efforts, business, financial condition, results of operations, strategies or prospects, as well as statements relating to

the registered direct offering and concurrent private placement, including as to the consummation of the offering described above, the

expected proceeds from the offering, the intended use of proceeds and the timing of the closing of the offering. In addition, from time

to time, Can-Fite or its representatives have made or may make forward-looking statements, orally or in writing. Forward-looking statements

can be identified by the use of forward-looking words such as "believe," "expect," "intend," "plan,"

"may," "should" or "anticipate" or their negatives or other variations of these words or other comparable

words or by the fact that these statements do not relate strictly to historical or current matters. These forward-looking statements may

be included in, but are not limited to, various filings made by Can-Fite with the U.S. Securities and Exchange Commission, press releases

or oral statements made by or with the approval of one of Can-Fite's authorized executive officers. Forward-looking statements relate

to anticipated or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate

to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause Can-Fite's

actual results to differ materially from any future results expressed or implied by the forward-looking statements. Many factors could

cause Can-Fite's actual activities or results to differ materially from the activities and results anticipated in such forward-looking

statements. Factors that could cause our actual results to differ materially from those expressed or implied in such forward-looking statements

include, but are not limited to: the consummation of the offering described in the press release, our history of losses and needs for

additional capital to fund our operations and our inability to obtain additional capital on acceptable terms, or at all; uncertainties

of cash flows and inability to meet working capital needs; the impact of the COVID-19 pandemic; the initiation, timing, progress and results

of our preclinical studies, clinical trials and other product candidate development efforts; our ability to advance our product candidates

into clinical trials or to successfully complete our preclinical studies or clinical trials; our receipt of regulatory approvals for our

product candidates, and the timing of other regulatory filings and approvals; the clinical development, commercialization and market acceptance

of our product candidates; our ability to establish and maintain strategic partnerships and other corporate collaborations; the implementation

of our business model and strategic plans for our business and product candidates; the scope of protection we are able to establish and

maintain for intellectual property rights covering our product candidates and our ability to operate our business without infringing the

intellectual property rights of others; competitive companies, technologies and our industry; statements as to the impact of the political

and security situation in Israel on our business; and risks and other risk factors detailed in Can-Fite's filings with the SEC and

in its periodic filings with the TASE. In addition, Can-Fite operates in an industry sector where securities values are highly volatile

and may be influenced by economic and other factors beyond its control. Can-Fite does not undertake any obligation to publicly update

these forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.