Deep magnetic stimulation targeting the medial prefrontal and anterior cingulate cortices for methamphetamine use disorder: a randomised, double-blind, sham-controlled study

Prior research has underscored the importance of cravings in substance use disorders (SUDs) and the potential of repetitive transcranial magnetic stimulation (rTMS) in mitigating these cravings. Crucial brain regions, including the medial prefrontal cortex (MPFC) and anterior cingulate cortex (ACC), are implicated in the generation of cravings, rendering them promising targets for rTMS intervention.

This study presents evidence that chronic rTMS directed at the MPFC and ACC leads to a significant reduction in cue-induced cravings among individuals with methamphetamine use disorder (MUD). Additionally, the study indicates the modulation of neural oscillation signatures, particularly a reduction in MPFC beta oscillation in the 10 Hz group.

The findings of this study have the potential to shape future research and clinical practices by offering support for the use of rTMS in addiction treatment. Moreover, it underscores the relevance of alterations in neural networks in the pathology of addiction