Full Press Release Details
Bristol Myers Squibb Reports First Quarter Financial Results for 2024
Performance Reflects Execution and Actions to Strengthen the Company's Long-Term Growth Profile
First Quarter Revenues were $11.9 Billion, increasing 5% (+6% Adjusting for Foreign Exchange)
Growth Portfolio Revenues were $4.8 Billion, increasing 8% (+11% Adjusting for Foreign Exchange)
Strengthened Long-Term Growth Profile Through Completion of Karuna Therapeutics, RayzeBio, Mirati Therapeutics, and SystImmune Transactions
Including the One-Time Net Impact of Acquired IPRD Charges and Licensing Income of $(6.30) From Recently Closed Transactions, GAAP Loss Per Share was $(5.89) Non-GAAP Loss Per Share was $(4.40)
Achieved U.S. Approval of Abecma in Earlier-Line Multiple Myeloma and Breyanzi in Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma and Positive Proof of Concept for Opdualag in Non-Small Cell Lung Cancer
Executing a Strategic Productivity Initiative to Deliver $1.5 Billion in Cost Savings, the Majority of Which Will be Reinvested to Fund Innovation and Drive Growth
Updating 2024 Non-GAAP EPS and Line-Item Guidance to Reflect Impact of Recently Completed Transactions
(PRINCETON, N.J., April 25, 2024) - Bristol Myers Squibb (NYSE BMY) today reports results for the first quarter of 2024, which reflect meaningful progress in the company's growth portfolio and pipeline.
"We had a good start to 2024, with revenue growth, important advances in our pipeline and the closure of several strategically important transactions," said Christopher Boerner, Ph.D., board chair and chief executive officer, Bristol Myers Squibb. "Our focus remains on strengthening the company's long-term growth profile. As a part of our continued evolution, we're executing a strategic productivity initiative that will allow us to be more agile, drive efficiency across the company, and prioritize investing in opportunities where we see the greatest potential to get the most promising medicines to patients as quickly as possible.
| First Quarter | |||||||||||||||||||
| $ in millions, except per share amounts | 2024 | 2023 | Change | Change Excl. F X** | |||||||||||||||
| Total Revenues | $11,865 | $11,337 | 5 | % | 6 | % | |||||||||||||
| (Loss) Earnings Per Share - GAAP* | (5.89) | 1.07 | N A | N A | |||||||||||||||
| (Loss) Earnings Per Share - Non-GAAP* ** | (4.40) | 2.05 | N A | N A | |||||||||||||||
| Acquired IPRD charge and Licensing Income Net Impact on Earnings Per Share | (6.30) | (0.01) | N A | N A |
* GAAP and Non-GAAP loss per share include the net impact of Acquired IPRD charges and licensing income primarily driven by the Karuna Therapeutics asset acquisition and SystImmune collaboration.
** See Use of Non-GAAP Financial Information .
FIRST QUARTER RESULTS
All comparisons are made versus the same period in 2023 unless otherwise stated.
Bristol Myers Squibb posted first quarter revenues of $11.9 billion, an increase of 5% or 6% when adjusted for foreign exchange impacts, primarily driven by Eliquis, Reblozyl and Opdualag, partially offset by Opdivo and Revlimid.
U.S. revenues increased 7% to $8.5 billion primarily due to Eliquis, Reblozyl and Opdualag, partially offset by Revlimid. Opdivo revenues were $1.2 billion compared to $1.3 billion, representing a decrease of 10% primarily due to inventory and the timing of orders, partially offset by demand growth.
International revenues remained relatively flat at $3.4 billion primarily due to lower average net selling prices, offset in part by higher demand for Opdivo, Yervoy and Reblozyl. The negative impact from foreign exchange was 5%.
On a GAAP basis, gross margin decreased from 77.4% to 75.3%, and on a non-GAAP basis, gross margin decreased from 77.8% to 75.5%, primarily due to product mix.
On a GAAP basis, marketing, selling and administrative expenses increased 34% to $2.4 billion and on a non-GAAP basis, increased 13% to $2.0 billion, primarily due to the timing of spend and the impact of recent acquisitions.
On a GAAP basis, research and development expenses increased 16% to $2.7 billion and on a non-GAAP basis, increased 6% to $2.3 billion, primarily due to the impact of recent acquisitions and higher costs to support the overall portfolio.
On a GAAP and non-GAAP basis, Acquired IPRD increased to $12.9 billion from $75 million, primarily due to the Karuna asset acquisition and SystImmune collaboration. On a GAAP and non-GAAP basis, licensing income was $12 million compared to $43 million during the same period a year ago.
On a GAAP basis, amortization of acquired intangible assets increased 4% to $2.4 billion, primarily due to the Mirati Therapeutics and RayzeBio acquisitions and approval of Augtyro in the fourth quarter of 2023.
On a GAAP basis, income tax expense was $392 million on a pre-tax loss of $11.5 billion and on a non-GAAP basis, income tax expense was $732 million on a pre-tax loss of $8.2 billion primarily due to the $12.1 billion one-time, non-tax-deductible charge for the acquisition of Karuna.
On a GAAP basis, the company reported net loss attributable to Bristol Myers Squibb of $11.9 billion, or ($5.89) per share, during the first quarter of 2024 compared to net earnings of $2.3 billion, or $1.07 per share, for the same period a year ago. In addition to the items above, the decrease was also due to lower litigation and other settlement income. The company reported on a non-GAAP basis net loss attributable to Bristol Myers Squibb of $8.9 billion, or ($4.40) per share, during the first quarter of 2024 compared to net earnings of $4.3 billion, or $2.05 per share, for the same period a year ago. In addition to the items above, the decrease was also due to higher interest expense resulting from new debt issuance to fund recent acquisitions.
FIRST QUARTER PRODUCT REVENUE HIGHLIGHTS
| ($ amounts in millions) | Quarter Ended March 31, 2024 | % Change from Quarter Ended March 31, 2023 | % Change from Quarter Ended March 31, 2023 Ex-F X** | ||||||||||||||||||||||||
| U.S. | Int'l (c) | WW (d) | U.S. | Int'l (c) | WW (d) | Int'l (c) | WW (d) | ||||||||||||||||||||
| Growth Portfolio | |||||||||||||||||||||||||||
| Opdivo | $ | 1,155 | $ | 923 | $ | 2,078 | (10) | % | - | % | (6) | % | 9 | % | (2) | % | |||||||||||
| Orencia | 572 | 226 | 798 | 4 | % | 6 | % | 4 | % | 13 | % | 6 | % | ||||||||||||||
| Yervoy | 368 | 215 | 583 | 18 | % | 10 | % | 15 | % | 17 | % | 18 | % | ||||||||||||||
| Reblozyl | 293 | 61 | 354 | 88 | % | 22 | % | 72 | % | 22 | % | 72 | % | ||||||||||||||
| Opdualag | 198 | 8 | 206 | 71 | % | * | 76 | % | * | 76 | % | ||||||||||||||||
| Abecma | 52 | 30 | 82 | (56) | % | 3 | % | (44) | % | 7 | % | (44) | % | ||||||||||||||
| Zeposia | 72 | 38 | 110 | 41 | % | 41 | % | 41 | % | 41 | % | 41 | % | ||||||||||||||
| Breyanzi | 87 | 20 | 107 | 50 | % | 54 | % | 51 | % | 54 | % | 51 | % | ||||||||||||||
| Camzyos | 77 | 7 | 84 | * | N A | * | N A | * | |||||||||||||||||||
| Sotyktu | 34 | 10 | 44 | * | * | * | * | * | |||||||||||||||||||
| Augtyro | 6 | - | 6 | N A | N A | N A | N A | N A | |||||||||||||||||||
| Krazati | 21 | - | 21 | N A | N A | N A | N A | N A | |||||||||||||||||||
| Other Growth Products (a) | 148 | 171 | 319 | 3 | % | 26 | % | 14 | % | 30 | % | 16 | % | ||||||||||||||
| Total Growth Portfolio | 3,083 | 1,709 | 4,792 | 9 | % | 8 | % | 8 | % | 15 | % | 11 | % | ||||||||||||||
| Legacy Portfolio | |||||||||||||||||||||||||||
| Eliquis | 2,821 | 899 | 3,720 | 12 | % | - | % | 9 | % | 1 | % | 9 | % | ||||||||||||||
| Revlimid | 1,453 | 216 | 1,669 | (5) | % | (5) | % | (5) | % | (1) | % | (4) | % | ||||||||||||||
| Pomalyst Imnovid | 597 | 268 | 865 | 10 | % | (8) | % | 4 | % | (7) | % | 4 | % | ||||||||||||||
| Sprycel | 282 | 92 | 374 | (2) | % | (34) | % | (13) | % | (30) | % | (11) | % | ||||||||||||||
| Abraxane | 145 | 72 | 217 | (10) | % | (8) | % | (9) | % | 10 | % | (3) | % | ||||||||||||||
| Other Legacy Products (b) | 95 | 133 | 228 | 19 | % | (20) | % | (7) | % | (17) | % | (6) | % | ||||||||||||||
| Total Legacy Portfolio | 5,393 | 1,680 | 7,073 | 5 | % | (7) | % | 2 | % | (4) | % | 3 | % | ||||||||||||||
| Total Revenues | $ | 8,476 | $ | 3,389 | $ | 11,865 | 7 | % | - | % | 5 | % | 5 | % | 6 | % |
* In excess of +100%
** See Use of Non-GAAP Financial Information .
(a) Includes Nulojix, Onureg, Inrebic, Empliciti and royalty revenue.
(b) Includes other mature brands.
(c) Beginning in 2024, Puerto Rico revenues are included in International revenues. Prior period amounts have been reclassified to conform to the current presentation.
(d) Worldwide (WW) includes U.S. and International (Int'l).
FIRST QUARTER PRODUCT REVENUE HIGHLIGHTS
Growth Portfolio worldwide revenues increased to $4.8 billion compared to $4.4 billion in the prior year period, representing growth of 8%, or 11% when adjusted for foreign exchange impacts. Growth Portfolio revenues were primarily driven by higher demand for Reblozyl, Opdualag, Yervoy, Camzyos, and Sotyktu, partially offset by Opdivo and Abecma.
Revenues for the Legacy Portfolio in the first quarter were $7.1 billion compared to $6.9 billion in the prior year period. Legacy Portfolio revenues were largely driven by a 9% increase in Eliquis worldwide revenues on a reported basis and when adjusted for foreign exchange impacts, partially
offset by a decline in Revlimid worldwide revenues of 5%, or 4% when adjusted for foreign exchange impacts.
PRODUCT AND PIPELINE UPDATE
| Category | Asset | Milestone |
| Clinical Research | Camzyos (mavacamten) | An analysis of results from the 10-month post-launch evaluation of the Camzyos REMS Program in 1,524 patients demonstrated that approximately 1% of patients reported clinical heart failure requiring hospitalization and 2.8% of patients reported a decrease in left ventricular ejection fraction to 50%. |
| Category | Asset | Milestone |
| Regulatory | Opdivo (nivolumab) | The U.S. Food and Drug Administration (FDA) approved Opdivo , in combination with cisplatin and gemcitabine, for the first-line treatment of adult patients with unresectable or metastatic urothelial carcinoma (UC). The approval is based on results from the Phase 3 CheckMate -901 trial evaluating Opdivo in combination with cisplatin and gemcitabine followed by Opdivo monotherapy, compared to cisplatin-gemcitabine alone, for patients with previously untreated unresectable or metastatic UC. |
| Krazati (adagrasib) | The FDA accepted the supplemental New Drug Application (sNDA) for Krazati in combination with cetuximab for the treatment of patients with previously treated KRAS G12C -mutated locally advanced or metastatic colorectal cancer. The acceptance was based on the results of the Phase 1 2 KRYSTAL-1 trial. The FDA granted the application Priority Review and assigned a Prescription Drug User Fee Act (PDUFA) goal date of June 21, 2024. | |
| Augtyro TM (repotrectinib) | The FDA accepted the sNDA for Augtyro for the treatment of adult and pediatric patients 12 years of age and older with NTRK-positive locally advanced or metastatic solid tumors. The acceptance is based on results from the registrational Phase 1 2 TRIDENT-1 trial and the CARE study. The FDA granted the application Priority Review and assigned a PDUFA goal date of June 15, 2024. | |
| Opdivo | The FDA accepted the supplemental Biologics Application (sBLA) for neoadjuvant Opdivo for the perioperative treatment of resectable stage IIA to IIIB non-small cell lung cancer (NSCLC). The FDA assigned a PDUFA goal date of October 8, 2024. In addition, the European Medicines Agency (EMA) validated the type II variation application for neoadjuvant Opdivo with chemotherapy followed by surgery and adjuvant Opdivo for the perioperative treatment of resectable stage IIA to IIIB NSCLC. Application validation confirms the submission is complete and begins the EMA's centralized review procedure. The FDA's sBLA acceptance and the EMA's application validation are based on results from the Phase 3 CheckMate -77T trial. |
| Clinical Research | Krazati | The pivotal Phase 3 KRYSTAL-12 study , evaluating Krazati as a monotherapy in patients with pretreated locally advanced or metastatic NSCLC harboring a KRAS G12C mutation, met the primary endpoint of progression-free survival (PFS) and the key secondary endpoint of overall response rate as assessed by Blinded Independent Central Review at final analysis for these endpoints. The study remains ongoing to assess the additional key secondary endpoint of overall survival. |
| Krazati | Data from the cohorts of the Phase 1 2 KRYSTAL-1 study evaluating Krazati in combination with cetuximab for the treatment of patients with previously treated KRAS G12C -mutated locally advanced or metastatic colorectal cancer demonstrated clinically meaningful activity. With a median follow up of 11.9 months in 94 patients, Krazati plus cetuximab demonstrated an objective response rate of 34%, median PFS of 6.9 months, and median overall survival of 15.9 months in pre-treated patients. | |
| Opdualag TM (nivolumab and relatlimab) | Initial data from a randomized Phase 2 study evaluating Opdualag in NSCLC support the initiation of a Phase 3 trial in 2024 evaluating Opdualag plus chemotherapy versus PD-1 PD-L1 plus chemotherapy in an important segment of the disease. Phase 2 data is expected to be disclosed later this year. | |
| Opdivo+Yervoy | The Phase 3 CheckMate -9DW trial evaluating Opdivo plus Yervoy as a first-line treatment for patients with advanced hepatocellular carcinoma who have not received a prior systemic therapy met its primary endpoint of improved overall survival compared to investigator's choice of sorafenib or lenvatinib at a pre-specified interim analysis. |
| Category | Asset | Milestone |
| Regulatory | Abecma (idecabtagene vicleucel) | The European Commission (EC) approved Abecma for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least two prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody and have demonstrated disease progression on the last therapy. The approval is based on results from the Phase 3 KarMMa-3 trial. Abecma is the first CAR T cell immunotherapy approved in the European Union for use in earlier lines of therapy for relapsed and refractory multiple myeloma. |
| Abecma | The FDA approved Abecma for the treatment of adult patients with relapsed or refractory multiple myeloma after two or more prior lines of therapy, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody. The approval is based on results from the Phase 3 KarMMa-3 trial. Abecma is being jointly developed and commercialized in the U.S. by Bristol Myers Squibb and 2seventy bio, Inc. | |
| Breyanzi (lisocabtagene maraleucel) | The FDA granted accelerated approval of Breyanzi for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma who have received at least two prior lines of therapy, including a Bruton tyrosine kinase inhibitor and a B-cell lymphoma 2 inhibitor. The accelerated approval is based on the Phase 1 2 open-label, single-arm TRANSCEND CLL 004 trial. |
| Category | Asset | Milestone |
| Clinical Research | Zeposia ( ozanimod) | First of two induction Phase 3 YELLOWSTONE trials evaluating Zeposia in adult patients with moderate-to-severe active Crohn's disease did not meet its primary endpoint of clinical remission at Week 12. The safety profile of Zeposia in this study was consistent with that observed in previously reported trials. |
| Zeposia | Data from the Phase 3 DAYBREAK open-label extension trial demonstrated the long-term efficacy and safety profile of Zeposia in patients with relapsing forms of multiple sclerosis. In the DAYBREAK long-term extension study, treatment with Zeposia demonstrated a low annualized relapse rate of 0.098 and 67% of patients were relapse-free at six years. An analysis of DAYBREAK data showed nearly 97% of followed patients were relapse-free at 90 days post Zeposia discontinuation. Patients that did relapse showed no evidence of rebound effect. |
| Category | Asset | Milestone |
| Clinical Research | KarXT (xanomeline-trospium) | Interim long-term efficacy data from the Phase 3 EMERGENT-4 open-label extension trial demonstrated that KarXT was associated with significant improvement in symptoms of schizophrenia across all efficacy measures at 52 weeks. In addition, pooled interim long-term safety, tolerability and metabolic outcomes data from the Phase 3 EMERGENT-4 and EMERGENT-5 trials evaluating the safety, tolerability and efficacy of KarXT in adults with schizophrenia showed that KarXT demonstrated a favorable weight and long-term metabolic profile where most patients experience stability or improvements on key metabolic parameters over 52 weeks of treatment. KarXT was generally well-tolerated, with a side effect profile consistent with prior trials of KarXT in schizophrenia. |
Business Development
The company recently completed multiple transactions, strengthening its long-term growth profile and enhancing its portfolio and pipeline.
With the acquisition of Karuna Therapeutics, Inc., Bristol Myers Squibb expanded its position in neuroscience and added important assets, including KarXT, an antipsychotic with a novel mechanism of action and differentiated efficacy and safety. KarXT has a PDUFA goal date of September 26, 2024, for the treatment of schizophrenia in adults.
By acquiring RayzeBio, Inc., a clinical-stage radiopharmaceutical therapeutics company with a differentiated platform and state-of-the-art manufacturing capabilities, Bristol Myers Squibb further diversified its oncology portfolio and gained a rich pipeline of potentially first-in-class and best-in-class drug development programs currently targeting solid tumors.
Through the acquisition of Mirati Therapeutics, Inc., Bristol Myers Squibb strengthened its pipeline and added commercialized lung cancer medicine Krazati to its oncology portfolio, as well as several promising clinical assets.
The company completed an exclusive license and collaboration agreement with SystImmune to develop and commercialize a potentially first-in-class EGFRxHER3 bispecific antibody-drug conjugate with the potential to treat a variety of solid tumors, including lung and breast cancer.
On April 22, Bristol Myers Squibb and Cellares announced a worldwide capacity reservation and supply agreement for the manufacture of CAR T cell therapies. As a part of the agreement, Cellares will optimize, automate, and tech-transfer select Bristol Myers Squibb CAR T cell therapies onto its automated and high-throughput manufacturing platform, the Cell ShuttleTM. This agreement enables Bristol Myers Squibb to expand its manufacturing capacity, meeting the growing demand for its diverse range of cell therapies through a platform that is scalable and has the potential to improve turnaround time, bringing the promise of cell therapies to more patients faster.
Strategically Enhancing Productivity and Efficiency
Bristol Myers Squibb is executing a strategic productivity initiative that will drive approximately $1.5 billion in cost savings by the end of 2025, the majority of which will be reinvested to fund innovation and drive growth.
As a part of this initiative, the company is
Focusing resources on R D programs with the potential to deliver the greatest return on investment
Prioritizing investing in key growth brands and
Optimizing operations across the organization.
Company executives will provide additional details on these actions during the company's first quarter 2024 earnings conference call.
As previously communicated, Bristol Myers Squibb is updating portions of its 2024 line-item guidance, including Non-GAAP EPS, to reflect the impact of recent transactions.
Non-GAAP EPS was updated to account for the following
| 2024 Non-GAAP EPS Guidance | |
| February Diluted EPS (Prior) | $7.10 - $7.40 |
| Acquired IPRD Impact 1 | ($6.30) |
| Dilution Impact (RayzeBio) | ($0.13) |
| Dilution Impact (Karuna Therapeutics) | ($0.30) |
| Total Deals Impact | ($6.73) |
| Revised Diluted EPS | $0.40 - $0.70 |
1 Primarily represents the Acquired IPRD impact from the Karuna Therapeutics asset acquisition and SystImmune
Non-GAAP other income (expense) was updated primarily due to the financing of the recent acquisitions.
Non-GAAP tax rate was updated to approximately 69% to reflect the impact of a $12.1 billion one-time, non-tax-deductible IPRD charge from the Karuna Therapeutics acquisition, which is expected to contribute 51% to the full-year tax rate.
2024 line-item guidance updates are
| Non-GAAP 2 | ||
| February (Prior) | April (Revised) | |
| Total Revenues | Low single-digit increase | No Change |
| Total Revenues (excl. F X) | Low single-digit increase | No Change |
| Gross Margin % | 74% | No Change |
| Operating Expenses 1 | Low single-digit increase | No Change |
| Other income (expense) | $250M | ($250M) |
| Effective tax rate | 17.5% | 69% |
| Diluted EPS | $7.10 to $7.40 | $0.40 to $0.70 |
1 Operating Expenses MS A and R D, excluding Acquired IPRD and Amortization of acquired intangible assets.
2 See Use of Non-GAAP Financial Information.
The 2024 financial guidance excludes the impact of any potential future strategic acquisitions, divestitures, specified items that have not yet been identified and quantified, and the impact of future Acquired IPRD charges. To the extent we have quantified the impact of significant R D charges or other income resulting from upfront or contingent milestone payments in connection with asset acquisitions or licensing of third-party intellectual property rights, we may update this information from time to time on our website www.bms.com, in the Investors section. Non-GAAP guidance assumes current exchange rates. The financial guidance is subject to risks and
uncertainties applicable to all forward-looking statements as described elsewhere in this press release.
A reconciliation of forward-looking non-GAAP measures, including non-GAAP EPS, to the most directly comparable GAAP measures is not provided because comparable GAAP measures for such measures are not reasonably accessible or reliable due to the inherent difficulty in forecasting and quantifying measures that would be necessary for such reconciliation. Namely, we are not without unreasonable effort, able to reliably predict the impact of accelerated depreciation and impairment charges, legal and other settlements, gains and losses from equity investments and other adjustments. In addition, the company believes such a reconciliation would imply a degree of precision and certainty that could be confusing to investors. These items are uncertain, depend on various factors and may have a material impact on our future GAAP results. See Cautionary Statement Regarding Forward-Looking Statements and Use of Non-GAAP Financial Information.
Environmental, Social Governance (ESG)
As a leading biopharmaceutical company, Bristol Myers Squibb's passion for making an impact extends beyond the discovery, development and delivery of innovative medicines that help patients prevail over serious diseases.
On April 2, 2024, the company published its latest ESG report, which details the company's meaningful progress, its evolved ESG strategy, and its long-term aspirational ESG goals. The company's evolved approach further integrates its ESG strategy and its business strategy. The ESG strategy focuses on three core pillars advancing patient health around the world, expanding the boundaries of science, and fostering a high-performing and inclusive global workforce.
Highlights from the report include
Advancing tailored access programs in low-and middle-income countries
Making clinical trials more accessible to underrepresented groups and ensuring research efforts better reflect patient populations
Sustained workforce representation and increased community engagement by the company's employees
Advancing climate action goals and increasing the company's renewable energy footprint and
Incorporating new ESG metrics into the executive compensation program and advancing data privacy and cybersecurity efforts.
Conference Call Information
Bristol Myers Squibb will host a conference call today, Thursday, April 25, 2024, at 8 00 a.m. ET during which company executives will review quarterly financial results and address inquiries from investors and analysts. Investors and the general public are invited to listen to a live webcast of the call at http investor.bms.com.
Investors and the public can register for the live conference call here. Those unable to register can access the live conference call by dialing in the U.S. toll-free 1-833-816-1116 or international +1 412-317-0705. Materials related to the call will be available at http investor.bms.com prior to the start of the conference call.
A replay of the webcast will be available at http investor.bms.com approximately three hours after the conference call concludes. A replay of the conference call will be available beginning at 11 30 a.m. ET on April 25, 2024, through 11 30 a.m. ET on May 9, 2024, by dialing in the U.S. toll free 1-877-344-7529 or international +1 412-317-0088, confirmation code 5034750.
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Use of Non-GAAP Financial Information
In discussing financial results and guidance, the company refers to financial measures that are not in accordance with U.S. Generally Accepted Accounting Principles (GAAP). The non-GAAP financial measures are provided as supplemental information to the financial measures presented in this press release that are calculated and presented in accordance with GAAP and are presented
because management has evaluated the company's financial results both including and excluding the adjusted items or the effects of foreign currency translation, as applicable, and believes that the non-GAAP financial measures presented portray the results of the company's baseline performance, supplement or enhance management's, analysts' and investors' overall understanding of the company's underlying financial performance and trends and facilitate comparisons among current, past and future periods. In addition, non-GAAP gross margin, which is gross profit excluding certain specified items, as a percentage of revenues, non-GAAP operating margin, which is gross profit less marketing, selling and administrative expenses and research and development expenses excluding certain specified items as a percentage of revenues, non-GAAP operating expenses, which is marketing, selling and administrative and research and development expenses excluding certain specified items, non-GAAP marketing, selling and administrative expenses, which is marketing, selling and administrative expenses excluding certain specified items, and non-GAAP research and development expenses, which is research and development expenses excluding certain specified items, are relevant and useful for investors because they allow investors to view performance in a manner similar to the method used by our management and make it easier for investors, analysts and peers to compare our operating performance to other companies in our industry and to compare our year-over-year results.
This earnings release and the accompanying tables also provide certain revenues and expenses as well as non-GAAP measures excluding the impact of foreign exchange ( Ex-Fx ). We calculate foreign exchange impacts by converting our current-period local currency financial results using the prior period average currency rates and comparing these adjusted amounts to our current-period results. Ex-Fx financial measures are not accounted for according to GAAP because they remove the effects of currency movements from GAAP results.
Non-GAAP financial measures such as non-GAAP earnings and related EPS information are adjusted to exclude certain costs, expenses, gains and losses and other specified items that are evaluated on an individual basis after considering their quantitative and qualitative aspects and typically have one or more of the following characteristics, such as being highly variable, difficult to project, unusual in nature, significant to the results of a particular period or not indicative of past or future operating results. These items are excluded from non-GAAP earnings and related EPS information because the company believes they neither relate to the ordinary course of the company's business nor reflect the company's underlying business performance. Similar charges or gains were recognized in prior periods and will likely reoccur in future periods, including amortization of acquired intangible assets, including product rights that generate a significant portion of our ongoing revenue and will recur until the intangible assets are fully amortized, unwind of inventory purchase price adjustments, acquisition and integration expenses, restructuring costs, accelerated depreciation and impairment of property, plant and equipment and intangible assets, costs of acquiring a priority review voucher, stock compensation resulting from acquisition-related equity awards, pension, legal and other contractual settlement charges, equity investment and contingent value rights fair value adjustments (including fair value adjustments attributed to limited partnership equity method investments), income resulting from the change in control of the Nimbus Therapeutics TYK2 Program and amortization of fair value adjustments of debt acquired from Celgene in our 2019 exchange offer, among other items. Deferred and current income taxes attributed to these items are also adjusted for considering their individual impact to the overall tax expense, deductibility and jurisdictional tax rates.
Because the non-GAAP financial measures are not calculated in accordance with GAAP, they should not be considered superior to and are not intended to be considered in isolation or as a substitute for the related financial measures presented in the press release that are prepared in accordance
with GAAP and may not be the same as or comparable to similarly titled measures presented by other companies due to possible differences in method and in the items being adjusted. We encourage investors to review our financial statements and publicly-filed reports in their entirety and not to rely on any single financial measure.
Reconciliations of the non-GAAP financial measures to the most comparable GAAP measures are provided in the accompanying financial tables and will also be available on the company's website at www.bms.com. Within the accompanying financial tables presented, certain columns and rows may not add due to the use of rounded numbers. Percentages and earnings per share amounts presented are calculated from the underlying amounts.
A reconciliation of forward-looking non-GAAP measures, including non-GAAP EPS, to the most directly comparable GAAP measures is not provided because comparable GAAP measures for such measures are not reasonably accessible or reliable due to the inherent difficulty in forecasting and quantifying measures that would be necessary for such reconciliation. Namely, we are not, without unreasonable effort, able to reliably predict the impact of accelerated depreciation and impairment charges, legal and other settlements, gains and losses from equity investments and other adjustments. In addition, the company believes such a reconciliation would imply a degree of precision and certainty that could be confusing to investors. These items are uncertain, depend on various factors and may have a material impact on our future GAAP results.
We routinely post important information for investors on our website, BMS.com, in the "Investors" section. We may use this website as a means of disclosing material, non-public information and for complying with our disclosure obligations under Regulation FD. Accordingly, investors should monitor the Investors section of our website, in addition to following our press releases, Securities and Exchange Commission ( SEC ) filings, public conference calls, presentations and webcasts. We may also use social media channels to communicate with our investors and the public about our company, our products and other matters, and those communications could be deemed to be material information. The information contained on, or that may be accessed through, our website or social media channels are not incorporated by reference into, and are not a part of, this document.
Cautionary Statement Regarding Forward-Looking Statements