Full Press Release Details
AI's Collaboration with Lieber Institute for Brain Development Yields Potentially Groundbreaking Biological Stratification of Brain
MD - January 17, 2024 - BullFrog AI Holdings, Inc. (NASDAQ: BFRG; BFRGW) ("BullFrog AI" or the "Company"),
a technology-enabled drug development company using artificial intelligence (AI) and machine learning to enable the successful development
of pharmaceuticals and biologics, today announced early results from its collaboration with the Lieber Institute for Brain Development
(LIBD) that could revolutionize the understanding and treatment of psychiatric disorders. The early findings from this global strategic
partnership have successfully stratified brain expression data, offering what may turn out to be unprecedented insights into psychiatric
collaboration marks a pivotal moment in psychiatric research," said Vin Singh, CEO of BullFrog AI. "By employing our bfLEAP
platform on LIBD's unrivaled brain data, we've gained invaluable ground into unraveling the biological underpinnings of psychiatric
disorders. These preliminary findings have the potential to not only deepen our understanding but also pave the way for developing more
targeted and effective treatments that set the stage for us to seek out revenue-generating strategic partnerships with pharmaceutical
proprietary data from LIBD included gene expression data from over 2,800 brain samples encompassing schizophrenia, bipolar disorder,
major depressive disorder, and non-psychiatric control brains. Utilizing graph analytics, BullFrog AI and LIBD have, for the first time,
clustered subjects based solely on their biological data, independent of their behavioral diagnoses. This innovative approach has yielded
promising insights, highlighting distinct differences and similarities in biological pathways across various brain disorders. Moreover,
it has revealed biological subtypes within individual disorders, offering a nuanced understanding that could lead to personalized treatment
R. Weinberger, M.D., Director and CEO of LIBD, added, "Our collaboration with BullFrog AI has enabled us to apply cutting-edge
AI technologies to our extensive brain data. The preliminary results are provocative and offer novel insights at the gene level that
may only be discoverable using these novel AI technologies, offering a new lens through which we can view and potentially treat brain
disorders. This is an important first step towards personalized medicine in psychiatry."
market opportunity for new treatments in psychiatric disorders is vast and underserved. With increasing global awareness and demand for
mental health solutions, this breakthrough presents a potential paradigm shift in treatment approaches. By identifying possible biological
subtypes within disorders, BullFrog AI and LIBD are not only advancing scientific understanding but also opening doors to novel therapeutic
pathways and personalized treatment strategies.
agreement between the organizations, announced in September 2023, granted BullFrog AI exclusive access to LIBD's brain data, with
the potential to commercialize products or services derived from the collaboration. The partnership represents a unique synergy between
AI-driven analysis and world-class neuropsychiatric research, setting a new standard in the pursuit of effective treatments for brain
the Lieber Institute for Brain Development (LIBD)
mission of the Lieber Institute for Brain Development and the Maltz Research Laboratories is to translate the understanding of
basic genetic and molecular mechanisms of schizophrenia and related developmental brain disorders into clinical advances that change
the lives of affected individuals. LIBD is an independent, not-for-profit 501(c)(3) organization and a Maryland tax-exempt medical research
institute. The Lieber Institute's brain repository of more than 4,000 human brains is the largest collection of postmortem brains
for the study of neuropsychiatric disorders in the world.
AI is a technology-enabled drug development company using Artificial Intelligence and machine learning to enable the successful development
of pharmaceuticals and biologics. Through its collaborations with leading research institutions, BullFrog AI is at the forefront of AI-driven
drug development using its proprietary bfLEAP artificial intelligence platform to create and analyze networks of biological, clinical,
and real-world data spanning from early discovery to late-stage clinical trials. BullFrog AI is deploying bfLEAP for use at several
critical stages of development with the intention of streamlining data analytics in therapeutics development, decreasing the overall
development costs by decreasing failure rates for new therapeutics.
more information visit BullFrog AI at:
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