BullFrog AI and Lieber Institute for Brain Development Collaboration Identifies Novel Drug Targets for Neuropsychiatric Disorders Gaithersburg, MD

AI and Lieber Institute for Brain Development Collaboration Identifies Novel Drug Targets for Neuropsychiatric Disorders

MD - May 16, 2024 - BullFrog AI Holdings, Inc. (NASDAQ: BFRG; BFRGW) ("BullFrog AI" or the "Company"),

a technology-enabled drug discovery company using artificial intelligence (AI) and machine learning to enable the successful discovery

and development of pharmaceuticals and biologics, today announced significant advancements in its collaboration with the Lieber Institute

for Brain Development (LIBD), including the identification of potential drug targets for multiple neuropsychiatric conditions.

AI and LIBD have made remarkable progress in identifying novel subgroups between and within neuropsychiatric disorders, including major

depression, schizophrenia, and bipolar disorder. Utilizing a combination of ensemble machine learning, generative AI, and graph analytics,

the team has successfully clustered patients by expression levels of gene isoforms across multiple brain regions. This innovative approach

led to the identification of dozens of clusters of patients, each exhibiting differential enrichment of neuropsychiatric conditions,

providing unprecedented insights into the biology of these disorders. These biological subtypes could ultimately lead to targeted therapeutics

for a more precise treatment of psychiatric disorders.

each identified cluster, key genes have been pinpointed that explain cluster membership. These genes present new potential drug targets

by revealing unique molecular mechanisms and pathways associated with each cluster. To prioritize these genes for wet lab validation,

BullFrog AI is now applying Causal AI, a crucial step for confirming the therapeutic potential of the identified targets.

collaboration continues to yield transformative insights into the biological underpinnings of neuropsychiatric disorders," said

Vin Singh, CEO of BullFrog AI. "The identification of these novel subgroups and key genes is a testament to the power of AI in

advancing precision medicine. Importantly, our proprietary bfLEAP platform, combined with LIBD's unparalleled brain data,

is paving the way for the development of targeted and effective treatments, and we have initiated engagement with pharmaceutical companies

with an objective of securing multiple strategic partnerships in the coming quarters."

R. Weinberger, M.D., Director and CEO of LIBD, added, "Our partnership with BullFrog AI has unlocked new pathways for understanding

the complexities of brain disorders. These findings not only advance our scientific knowledge but also open new avenues for developing

targeted therapies that can improve patient outcomes. We are excited about the potential impact this collaboration holds for the future

of neuropsychiatric treatments."

collaboration between BullFrog AI and LIBD, announced in September 2023, leverages the bfLEAP platform to mine LIBD's comprehensive

brain data. This data includes transcriptomic, genomic, DNA methylation, cell-line, clinical, and imaging data from over 2,800 brain

samples. Early results announced in January 2024 highlighted the ability to stratify brain expression data, revealing biological subtypes

within psychiatric disorders.

potential for new treatments for psychiatric disorders is vast and underserved. With increasing global awareness and demand for mental

health solutions, this breakthrough presents a potential paradigm shift in treatment approaches. By identifying possible biological subtypes

within disorders, BullFrog AI and LIBD are not only advancing scientific understanding, but also opening doors to novel therapeutic pathways

and personalized treatment strategies.

three-year agreement between the organizations granted BullFrog AI a period of exclusive access to LIBD's brain data with the potential

to commercialize products or services derived from the collaboration. The partnership represents a unique synergy between AI-driven analyses

and world-class neuropsychiatric research data, setting a new standard in the pursuit of effective treatments for brain disorders.

the Lieber Institute for Brain Development (LIBD)

mission of the Lieber Institute for Brain Development and the Maltz Research Laboratories is to translate the understanding of basic

genetic and molecular mechanisms of schizophrenia and related developmental brain disorders into clinical advances that change the lives

of affected individuals. LIBD is an independent, not-for-profit 501(c)(3) organization and a Maryland tax-exempt medical research institute.

The Lieber Institute's brain repository of more than 4,000 human brains is the largest collection of postmortem brains for the

study of neuropsychiatric disorders in the world.

AI is a technology-enabled drug development company using Artificial Intelligence and machine learning to enable the successful development

of pharmaceuticals and biologics. Through its collaborations with leading research institutions, BullFrog AI is at the forefront of AI-driven

drug development using its proprietary bfLEAP artificial intelligence platform to create and analyze networks of biological, clinical,

and real-world data spanning from early discovery to late-stage clinical trials. BullFrog AI is deploying bfLEAP for use at several

critical stages of development with the intention of streamlining data analytics in therapeutics development, decreasing the overall

development costs by decreasing failure rates for new therapeutics.

more information visit BullFrog AI at:

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