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marketing capabilities or develop broad awareness of our diagnostic tests to generate revenue growth, our failure to maintain our current relationships, or enter into new relationships, with biopharmaceutical companies, significant fluctuation in
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Execution play - First mover advantage addressing estimated 5
million patients at risk of having lung cancer Large market: Estimated 5 million patients with lung nodules with first 42% Year mover advantage over Year Growth in Five reimbursed tests: 5 blood-based Lung Diagnostic tests with Lung
Medicare coverage and various levels of private payer coverage Diagnostic Test 2Q24 Revenue growth over 2Q23: Volumes - Total Revenue grew 51% - Lung Diagnostic revenue grew 44% - Biopharmaceutical Services revenue grew
228% - FY2024 Guidance increased to $70-72 million from $65-68 million Strong gross margins: 78.4% in 2Q24 - up 5.7% points vs. 2Q23 Path to profitability: 2Q24 Net Loss improved by 19% and Adjusted EBITDA* improved 38%
reconciliation, please see Quarterly Earnings Press Releases at www. Biodesix.com Actual Lung Diagnostic Testing Volume 1Q22 2Q22 3Q22 4Q22 1Q23 2Q23 3Q23 4Q23 1Q24 2Q24
Two commercial channels driving growth Two revenue growth drivers
Biopharmaceutical and Lung Diagnostic Tests Diagnostic Services Focused on early diagnosis of Biomarker discovery, assay lung cancer and personalized design and development, clinical cancer treatment with best-in- trial testing and support, class
Biodesix operates two certified, high-complexity laboratories
LOUISVILLE, CO DE SOTO, KS CAP-accredited CAP-accredited CLIA-certified CLIA-certified NYS CLEP certified: Soluble Tumor NYS CLEP certified: Soluble Tumor Markers, Molecular & Cellular Tumor Markers &
Lung cancer is the leading cause of cancer deaths, but early detection
saves lives Lung cancer deaths versus colorectal, Few patients are diagnosed early when 1 breast, and prostate combined survival is up to 10x greater 60% 150,000 50% 120,000 Prostate 40% 90,000 Breast 30% Lung 60,000 20% Colorectal 30,000 10% 0% 0
Stage of Diagnosis 1 in 16 people will be 5-year survival for Only 5.8% of those diagnosed with lung metastatic cancer is only Deadliest of all cancers eligible were screened cancer in their lifetime 6% 1 2022E mortality in US (SEER) 2024
Five blood-based Medicare covered tests for the same patient population
with best-in-class turnaround times Lung Diagnostic Testing Portfolio Lung Cancer Risk Assessment Lung Cancer Diagnosis Nodule Risk Assessment Treatment Guidance Testing Identify likely Identify likely Identify actionable Identify actionable
1 Standard of care: Guideline directed lung nodule management Assessed
Risk of Lung Cancer or High Risk (>65%) Biopsy Surgery ~10% of patients Incidentally Biopsy Found Low to OR Moderate Screen Risk Physician Surgery Detected (5-65%) Judgement Lung Cancer Risk Assessment: ~80% of patients Lung Nodule Solitary
Standard lung cancer risk assessment has led to over- and
under-treatment of patients 62% 35% 17% of patients who underwent of patients sent to CT surveillance of patients receiving biopsy 1 2 surgery had benign nodules have malignant nodules as the sole diagnostic 1 procedure were benign 1 2024
One blood draw, two tests to reclassify risk to help reduce uncertainty
in lung nodule management Assessed Risk of Lung Cancer or High Risk (>65%) Biopsy Surgery identifies likely malignant ~10% of patients nodules with test results in one day Patient Chart Low to Clinical Profile Age ( 40) Moderate
Any Smoking History Risk No Cancer History Physician (5-65%) Judgement Radiologic Profile Lung Cancer Nodule Size (8-30mm) Risk identifies likely benign Nodule Spiculation Assessment: ~80% of patients or reduced risk
Five Medicare covered tests for the same patient population with
best-in-class turnaround times Lung Diagnostic Testing Portfolio Lung Cancer Risk Assessment Lung Cancer Diagnosis Treatment Guidance Testing Identify likely Identify likely Identify actionable Identify actionable Identify a patient's benign
Testing helps guide the right treatment to the right patient as quickly
as possible 26 days ~ 235k 10.5 months patients diagnosed annually median overall survival of Length of time for turnaround for 1 2 3 with NSCLC in the US patients with advanced stage NSCLC tissue testing 4 >60 treatments and combinations
(Suppl_15): e18519. 4. NCCN Guidelines v5.2024 Non-Small Cell Lung Cancer. NSCLJ1-6.
Treatment guidance tests for all stages of lung cancer Early stage
Robust pipeline to address additional clinical needs for the same
Biopharmaceutical and Diagnostic Services partnerships providing
research, discovery, new test development, and clinical study testing $8.1 M in Biopharma Services under contract but not yet recognized Our Partners Our Biopharma Partnerships 60+ biopharma customers and academic partners Partnerships with 9 of the
Execution play - First mover advantage addressing estimated 5
million patients at risk of having lung cancer Large market: Estimated 5 million patients with lung nodules with first 42% Year mover advantage over Year Growth in Five reimbursed tests: 5 blood-based Lung Diagnostic tests with Lung
Medicare coverage and various levels of private payer coverage Diagnostic Test 2Q24 Revenue growth over 2Q23: Volumes - Total Revenue grew 51% - Lung Diagnostic revenue grew 44% - Biopharmaceutical Services revenue grew
228% - FY2024 Guidance increased to $70-72 million from $65-68 million Strong gross margins: 78.4% in 2Q24 - up 5.7% points vs. 2Q23 Path to profitability: 2Q24 Net Loss improved by 19% and Adjusted EBITDA* improved 38%
reconciliation, please see Quarterly Earnings Press Releases at www. Biodesix.com Actual Lung Diagnostic Testing Volume 1Q22 2Q22 3Q22 4Q22 1Q23 2Q23 3Q23 4Q23 1Q24 2Q24
Extensive knowledge and experience in diagnostics & reimbursement
Scott Hutton Robin Harper Cowie Gary Pestano Kieran O'Kane Chris Vazquez CEO CFO CDO (PhD) CCO CAO Niki Givens Mark DeBlock Steven Springmeyer James Jett Brianna Phillips VP Clin Dev VP Sales CMO (MD) CMO (MD) VP Qual & Reg 2024
Blood-Based Nodule Risk Assessment Ordered together - Run in sequence
Identifies patients with lung nodules that Identifies patients with lung nodules that are likely malignant are likely benign Proteins on an LC-MS platform from blood Autoantibodies on an ELISA platform from blood Proteins: LG3BP | C163A P53 | CAGE |
NY-ESO-1|GBU4-5 | MAGE A4 | SOX2 | HuD Clinical Profile: Age | Smoking History | Cancer History Radiologic Profile: Nodule Size | Location | Spiculation 78% PPV, 98% specificity & 28% sensitivity 98% NPV, 97% sensitivity & 44% specificity 1
business day turnaround time 4-5 business days turnaround time Medicare and new Private Payer coverage Medicare and new Private Payer coverage with a unique CPT code & ADLT status ($3,520) with a unique CPT code & ADLT status ($649) Two
Rapid Turn-Around Blood-Based Tumor & Immune Profiling Blood-based
test identifies a chronic Identifies blood-based, guideline Identifies blood-based, guideline inflammatory disease state associated recommended NSCLC tumor mutations recommended tumor mutations with compromised immune system leading to poorer
outcomes 52 genes including somatic nucleotide Proprietary proteomic signature BRAF, EGFR, KRAS, ALK variants, indels, copy number identified from blood by MALDI-ToF amplification and rearrangements Mass Spectrometry VeriStrat Good test result (2x
median 91% sensitivity & 100% specificity 95% sensitivity & 100% specificity overall survival) vs. VeriStrat Poor test result Average 2-3 business day turnaround Average 2-3 business day turnaround Average 2-3 business day turnaround time
time time Medicare and private payer coverage Medicare and private payer coverage Medicare and private payer coverage Can be ordered multiple times per One per patient per cancer per with a unique CPT code & ADLT status patient (~$600 based on #
In-Office Blood Collection with Tasso+ Capillary Device
Improves patient access to Nodify Lung testing in practices without convenient access to venous draw services Administered in minutes by any healthcare provider without need for Impact to Lung Nodule Patient Care venipuncture
Single-use blood lancing device Virtually painless sample collection intended for obtaining capillary whole Improves care delivery by accelerating blood samples from a patient's upper time to results and preventing patients arm
from making a second trip to have FDA Class II Lancet 510(k) cleared blood drawn "Oneida Health is a referral center serving patients in a wide geographical area. This device has allowed us to order Nodify Lung testing when patients
are here for visits, ensuring that we get the critical information to inform the shared decision-making process quickly and accelerate the time to diagnosis." Tasso+ Device - Pedro Del Pino, MD, Oneida Health 2024 Biodesix, Inc. All
Intellectual property portfolio >100 issued patents 25 unique
registered and US and foreign filed trademarks across 11 countries Patent Subject Matter: Exemplary Issued Marks: Filed Marks: VeriStrat and Nodify tests and their uses in non-small Biodesix IQlung cell lung and
other diseases (e.g., breast cancer, Biodesix Lung Reflex IQlung + Logo prostate cancer, liver cancer, graft v. host disease) VeriStrat DeepMALDI mass spectrometry methods GeneStrat Classifier
development using the Diagnostic Cortex AI DeepMALDI platform Diagnostic Cortex Pipeline tests using proteomic testing in immunotherapies ImmunoStrat Biodesix Blood Collection Device Nodify rd
A Board of Directors with a vast amount of industry expertise John
Patience Crabtree Partners LLC CHAIRMAN Scott Hutton PRESIDENT & CEO Hany Massarany CHAIR - COMPENSATION COMMITTEE Jean Franchi CHAIR - AUDIT COMMITTEE Matt Strobeck Birchview Capital CHAIR - NOMINATIONS & GOVERNANCE COMMITTEE Jack Schuler