Full Press Release Details
Bicycle Therapeutics Announces First Human Imaging
Data from European Association of Nuclear Medicine 2024 Congress and Outlines Strategy for Leadership in Next-Generation Radiopharmaceuticals
First human imaging data validate the potential
of MT1-MMP as a novel target in the treatment of cancer and demonstrate positive properties of Bicycle Radionuclide Conjugates (BRC )
for radiopharmaceutical use
Additional preclinical data demonstrate biodistribution
of BRCs can be optimized to maintain high tumor uptake while significantly reducing kidney levels
Company strategy focuses on pursuing novel targets
using a range of isotopes to develop radiopharmaceuticals with first-in-class potential
Bicycle to host conference call and webcast today
CAMBRIDGE, England & BOSTON, October 23, 2024 -
Bicycle Therapeutics plc (NASDAQ: BCYC), a pharmaceutical company pioneering a new and differentiated class of therapeutics based on its
proprietary bicyclic peptide (Bicycle ) technology, today announced the presentation of the first human imaging data validating
the potential of MT1-MMP as a novel target in the treatment of cancer and demonstrating the positive properties of Bicycle Radionuclide
Conjugates (BRC ) for radiopharmaceutical use, as well as preclinical data demonstrating optimized BRC radioisotope delivery
at the European Association of Nuclear Medicine (EANM) 2024 Congress in Hamburg, Germany.
"Since our founding, our goal at Bicycle Therapeutics has been
to leverage the power of our platform in areas where we can have the most impact for patients. Over the years, we have built a robust
pipeline of oncology therapies that includes targeted drug conjugates, immuno-oncology agents and now, radiopharmaceuticals," said
CEO Kevin Lee, Ph.D. "The exciting data presented at EANM underscore the potential of our Bicycle Radionuclide Conjugates to deliver
a range of isotopes to novel cancer targets. Through our strategy of pursuing novel targets with first-in-class potential and selecting
the isotope that best aligns with the target biology and indication, we have an opportunity to potentially broaden the use of radiopharmaceuticals
to diagnose and treat cancer."
In line with Bicycle Therapeutics' radiopharmaceuticals strategy,
the company selected tumor antigen EphA2 as its second BRC target and signed a letter of intent with leading isotope technology company
Eckert & Ziegler to put in place an agreement to supply a range of radioisotopes and develop and manufacture BRC molecules. Bicycle
Therapeutics, through its internal pipeline of wholly owned molecules and strategic collaborations with industry and academic leaders
in the field, aims to be at the forefront of the development of next-generation radiopharmaceutical therapies. Bicycle
molecules have ideal properties for radioisotope delivery due to their low molecular weight, high selectivity and affinity for their intended
target and rapid systemic clearance.
"The data presented at EANM demonstrate how our Bicycle
platform is a powerful tool for de novo identification of high-quality binders to important cancer targets. We believe the ability to
optimize the biodistribution properties of our molecules, significantly reducing kidney retention while retaining rapid, selective uptake
in tumors, position Bicycle Radionuclide Conjugates as a potentially best-in-class approach for targeted radionuclide therapy,"
said Michael Skynner, Ph.D., chief technology officer of Bicycle Therapeutics. "MT1-MMP is the first target for radiopharmaceutical
development that we are pursuing given its expression in many solid tumors such as non-small cell lung cancer, esophageal and triple negative
EANM 2024 Congress Data Highlights
During an oral presentation, the German Cancer Consortium (DKTK) presented
first human imaging data for a BRC targeting MT1-MMP. They focused on a case study in a 65-year-old male diagnosed with advanced pulmonary
adenocarcinoma, the most common type of non-small cell lung cancer, in the lung and lymph nodes confirmed by endobronchial ultrasound
(EBUS) biopsy. The patient received fluorine-18-labelled FDG-PET/CT imaging, and two weeks later received MT1-MMP PET/CT imaging up to
one hour post injection of the gallium-68-labelled BRC tracer.
Both scans revealed multiple lymph node metastases and bone metastases
in the sternum. MT1-MMP imaging demonstrated tracer uptake in the primary tumor in the lung and lymph node and bone metastases, consistent
with FDG imaging. Additionally, the MT1-MMP BRC tracer showed renal excretion, with all other organs showing only negligible tracer uptake.
Clear imaging contrast was also observed at early time points.
In an e-poster, Bicycle Therapeutics presented preclinical data demonstrating
the suitability of Bicycle molecules to deliver indium to tumors in vivo due to their favorable properties, including specific
tumor uptake, rapid tumor penetration and rapid renal elimination. Additionally, imaging showed how the biodistribution profile of BRCs
can be optimized to maintain high tumor uptake and retention while significantly reducing kidney uptake and retention. These data build
on the body of preclinical data the company has published in this area demonstrating the use of Bicycle molecules to effectively deliver
various radioisotopes, such as lutetium and lead, to tumors.
Altogether, the data presented at EANM validate the potential of MT1-MMP
as a novel target in the treatment of cancer, demonstrate the translatability of BRC preclinical data and highlight the potential of Bicycle
molecules for targeted radionuclide therapy.
The e-poster, "Bicycle Radionuclide Conjugates for radioisotope
delivery to solid tumors," is available in the Publications section of the Bicycle Therapeutics website.
Conference Call Details
Bicycle Therapeutics will host a conference call and webcast
today, Oct. 23, at 8 a.m. ET to review the first human imaging data and outline the company's radiopharmaceuticals
strategy. To access the call, please dial 833-816-1408 (U.S.) or +1-412-317-0501 (international) and ask to join the Bicycle Therapeutics
call. A live webcast and replay of the conference call will be accessible in the Investor section of the Company's website at www.bicycletherapeutics.com.
About Bicycle Therapeutics
Bicycle Therapeutics is a clinical-stage pharmaceutical company
developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing
therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize
their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive
candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle Toxin
Conjugate (BTC ) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically
undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA ) targeting
Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radionuclide
Conjugates (BRC ) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology
to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK,
with many key functions and members of its leadership team located in Cambridge, Mass. For more information, visit www.bicycletherapeutics.com.
Forward Looking Statements
This press release may contain forward-looking statements made pursuant
to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such
as "aims," "anticipates," "believes," "could," "estimates," "expects,"
"forecasts," "goal," "intends," "may," "plans," "possible," "potential,"
"seeks," "will" and variations of these words or similar expressions that are intended to identify forward-looking
statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include,
but are not limited to, statements regarding validation of MT1-MMP as a target for the treatment of cancer, the suitability of BRCs for
radiopharmaceutical use and the potential of this approach; Bicycle's plans for an agreement with Eckert & Ziegler to develop,
manufacture and supply a range of radioisotopes; Bicycle's anticipated progress across its internal and partnered pipelines in radiopharmaceuticals,
the translatability of Bicycle's BRC preclinical data and the ability of the Bicycle platform to identify binders for cancer targets;
Bicycle's development across its R&D pipeline and the advancement of its product candidates, including zelenectide pevedotin,
BT5528 and BT7480; and the therapeutic potential for Bicycles in oncology and other applications. Bicycle may not actually achieve the
plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking
statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking
statements as a result of various factors, including: uncertainties inherent in research and development and in the initiation, progress
and completion of preclinical studies and clinical trials and the identification and development of Bicycle's potential and current
product candidates; the risk that Bicycle may not realize the intended benefits of its platform, technology or partnerships; timing of
results from preclinical studies and clinical trials; whether the outcomes of preclinical studies will be predictive of clinical trial
results; the risk that preclinical studies and clinical trials may have unsatisfactory outcomes; potential adverse effects arising from
the testing or use of Bicycle's product candidates; the risk that Bicycle's management have not focused the company's
activities on the clinical programs and research areas with the highest potential to maximize value creation; and other important factors,
any of which could cause Bicycle's actual results to differ from those contained in the forward-looking statements, are described
in greater detail in the section entitled "Risk Factors" in Bicycle's Quarterly Report on Form 10-Q filed with
the Securities and Exchange Commission (SEC) on May 2, 2024, as well as in other filings Bicycle may make with the SEC in the future.