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BridgeBio to Present Additional Cardiovascular Outcomes Data from ATTRibute-CM at the HFSA Annual Scientific Meeting 2025

Key Takeaway: BridgeBio Pharma will present several studies related to Acoramidis at the HFSA Annual Scientific Meeting 2025, focusing on its effects on cardiovascular outcomes in patients with ATTR-CM. Key presentations will include findings on mortality rates and hospitalization reductions attributed to Acoramidis. Although the results are promising, some mild adverse effects were reported during trials, which were similar to those seen in placebo groups. This meeting provides a vital platform for disseminating these findings to the scientific and medical community.

Market Sentiment Analysis

POSITIVE FACTORS

  • BridgeBio is presenting promising data on Acoramidis at a significant scientific meeting.
  • The continuous treatment with Acoramidis showed a significant reduction in all-cause mortality and cardiovascular-related hospitalizations.
  • The publication includes multiple presentations that highlight the efficacy of Acoramidis in managing ATTR-CM.

CONCERNS & RISKS

  • Adverse reactions such as diarrhea and upper abdominal pain were noted, although mostly mild.
  • The data presented may still require further validation before widespread clinical acceptance.

Full Press Release Details

PALO ALTO, Calif., Sept. 22, 2025 (GLOBE NEWSWIRE) -- BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a new type of biopharmaceutical company focused on genetic diseases, announced today that one late breaking clinical trials oral presentation, one oral presentation, and three poster sessions will be shared at the Heart Failure Society of America (HFSA) Annual Scientific Meeting (ASM) 2025, taking place in Minneapolis, MN from September 26 - 29, 2025.
Late Breaking Clinical Trials Oral Presentation:
Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis from ATTRibute-CM
Presenter: Ahmad Masri, M.D., M.S., Oregon Health & Science University
Date/time: Sunday, September 28 at 10:15 am CT
Continuous Acoramidis Treatment Significantly Reduced Risk of All-cause Mortality and Cardiovascular-related Hospitalization at Month 42, in Patients with Wild-type and Variant Transthyretin Amyloidosis Cardiomyopathy
Presenter: Lily Stern, M.D., Cedars-Sinai Heart Institute
Date/time: Saturday, September 27 at 1:33 pm CT
Acoramidis Mitigates the Rise in NT-proBNP Levels Observed with Placebo in Patients with Variant Transthyretin Amyloid Cardiomyopathy: Results from ATTRibute-CM
Presenter: Nitasha Sarswat, M.D., UChicago Medicine
Date/time: Saturday, September 27 at 7:45 am CT
Effect of Acoramidis on Cardiac Conduction Abnormalities in Transthyretin Amyloid Cardiomyopathy
Presenter: Brett W. Sperry, M.D., Saint Luke's Health System
Date/time: Saturday, September 27 at 1:21 pm CT
State-Level Differences in Incidence of Transthyretin Amyloid Cardiomyopathy in United States Veterans Persist After Introduction of Disease-Modifying Therapy
Presenter: Sandesh Dev, M.D., Arizona State University
Date/time: Sunday, September 28 at 12:15 pm CT
About Attruby™ (acoramidis)
Attruby is a transthyretin stabilizer indicated for the treatment of the cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM) in adults to reduce cardiovascular death and cardiovascular-related hospitalization.
IMPORTANT SAFETY INFORMATION
Diarrhea (11.6% vs 7.6%) and upper abdominal pain (5.5% vs 1.4%) were reported in patients treated with Attruby versus placebo, respectively. The majority of these adverse reactions were mild and resolved without drug discontinuation. Discontinuation rates due to adverse events were similar between patients treated with Attruby versus placebo (9.3% and 8.5%, respectively).
BridgeBio Media Contact:
Bubba Murarka, Executive Vice President, Corporate Development
BridgeBio Investor Contact:
Chinmay Shukla, Senior Vice President, Strategic Finance

Frequently Asked Questions

What is the Heart Failure Society of America ASM 2025?

The HFSA Annual Scientific Meeting 2025 occurs in Minneapolis, MN, from September 26-29.

What is Attruby™ used for?

Attruby™ is a transthyretin stabilizer for treating cardiomyopathy related to ATTR-CM.

What side effects are associated with Attruby?

Common side effects include diarrhea and upper abdominal pain, mostly mild.

When will Acoramidis presentations take place?

Acoramidis presentations are scheduled for September 27 and 28 during HFSA 2025.

Who is presenting the late-breaking trial?

Dr. Ahmad Masri will present the late-breaking clinical trials oral presentation.

Last updated: Sep 22, 2025