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BridgeBio to Present Data from the Overall ATTR-CM Variant and V142I (V122I) Populations from ATTRibute-CM at the AHA Scientific Sessions 2025

Key Takeaway: BridgeBio Pharma will present ten moderated digital posters at the AHA Scientific Sessions 2025, showcasing findings from the ATTRibute-CM study. Key presentations will highlight the effects of Acoramidis on all-cause mortality and cardiovascular hospitalizations in patients with transthyretin amyloid cardiomyopathy. The event will take place from November 7-10, 2025, in New Orleans, LA.
Price reaction · baseline $62.64 (2025-10-31 close) · hit pre-market · 1 other BBIO headline(s) in the window, move may be shared
day 0 close · peak
-1.1%

Market Sentiment Analysis

POSITIVE FACTORS

  • BridgeBio is presenting significant data at a major scientific conference.
  • Acoramidis shows promising results in reducing all-cause mortality.
  • The company is focused on innovative treatments for genetic diseases.

CONCERNS & RISKS

  • Adverse reactions like diarrhea and abdominal pain were reported.
  • The study's findings may not be generalizable to all patient populations.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+41%
120-day peak, hindsight
Typical move
3.6%
average across 13 past catalysts
Cash runway
~30 mo
Minimal dilution risk
Lead asset
acoramidis
Phase 3 · Amyloidosis

Full Press Release Details

PALO ALTO, Calif., Nov. 03, 2025 (GLOBE NEWSWIRE) -- BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a new type of biopharmaceutical company focused on genetic diseases, announced today that ten moderated digital posters will be shared at the American Heart Association (AHA) Scientific Sessions 2025, taking place in New Orleans, LA from November 7 - 10, 2025.

Moderated Digital Posters:

Acoramidis Effect on All-Cause Mortality in Patients with p.V142I (V122I) Variant ATTR-CM: Findings from the ATTRibute-CM StudyPresenter:Marianna Fontana, M.D., University College London, UKDate/time:Saturday, November 8 at 3:15 pm CT
Acoramidis Reduces All-Cause Mortality and First Cardiovascular Hospitalization in Patients with Variant Transthyretin Amyloid Cardiomyopathy: Results from the ATTRibute-CM StudyPresenter:Prem Soman, M.D., Ph.D., University of Pittsburgh School of Medicine, U.S.Date/time:Saturday, November 8 at 9:15 am CT
Acoramidis Reduces All-Cause Mortality and Cardiovascular-Related Hospitalizations Through Month 42 in Transthyretin Amyloid Cardiomyopathy Across All Pre-specified Patient SubgroupsPresenter:Lily Stern, M.D., Cedars-Sinai Heart Institute, U.S.Date/time:Saturday, November 8 at 3:15 pm CT
Acoramidis Lowers NT-proBNP in a Larger Proportion of ATTRibute-CM Study Participants with Transthyretin Amyloid Cardiomyopathy Compared with Placebo, Independent of Atrial Fibrillation StatusPresenter:Mathew Maurer, M.D., Columbia University Irving Medical Center, U.S.Date/time:Saturday, November 8 at 9:15 am CT
Demographic Disparities in Tafamidis Treatment and Clinical Outcomes Across the United StatesPresenter:Nicole Cyrille-Superville, M.D., Atrium Health Sanger Heart & Vascular Institute Kenilworth, Charlotte, NC, U.S.Date/time:Saturday, November 8 at 12:15 pm CT
Geographic Disparities in Transthyretin Amyloid Cardiomyopathy Prevalence in United States VeteransPresenter:Sandesh Dev, M.D., Southern Arizona VA Health Care System, U.S.Date/time:Saturday, November 8 at 3:15 pm CT
Serum Transthyretin Levels at Day 28 are Associated with Cardiovascular Outcomes: Insights from the ATTRibute-CM StudyPresenter:Nitasha Sarswat, M.D., UChicago Medicine, U.S.Date/time:Sunday, November 9 at 3:15 pm CT
Acoramidis Improved Clinical Outcomes, Function, Quality of Life and NT-proBNP in Patients with Transthyretin Amyloid Cardiomyopathy Regardless of Atrial Fibrillation Status at BaselinePresenter:Richard Cheng, M.D., University of Washington, Seattle, WA, U.S.Date/time:Sunday, November 9 at 3:15 pm CT
Acoramidis Reduces the Risk of All-Cause Mortality and Cardiovascular-Related Hospitalization Compared with Placebo in Participants with Transthyretin Amyloid Cardiomyopathy and Early-Stage Heart Failure Regardless of Atrial Fibrillation History: Insights from ATTRibute-CMPresenter:Ronald Witteles, M.D., Stanford University School of Medicine, U.S.Date/time:Saturday, November 8 at 3:15 pm CT
Vutrisiran Healthcare Resource Utilization, Costs, Discontinuation, and Mortality: A Retrospective Database AnalysisPresenter:Nicole Bart, M.D., Ph.D., St Vincent's Hospital Sydney, AUDate/time:Monday, November 10 at 10:45 am CT

AboutAttruby™ (acoramidis)

INDICATIONAttruby is a transthyretin stabilizer indicated for the treatment of the cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM) in adults to reduce cardiovascular death and cardiovascular-related hospitalization.

IMPORTANT SAFETY INFORMATION

Adverse ReactionsDiarrhea (11.6% vs 7.6%) and upper abdominal pain (5.5% vs 1.4%) were reported in patients treated with Attruby versus placebo, respectively. The majority of these adverse reactions were mild and resolved without drug discontinuation. Discontinuation rates due to adverse events were similar between patients treated with Attruby versus placebo (9.3% and 8.5%, respectively).
About BridgeBioBridgeBio Pharma (BridgeBio; Nasdaq: BBIO) is a new type of biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases. BridgeBio’s pipeline of development programs ranges from early science to advanced clinical trials. BridgeBio was founded in 2015 and its team of experienced drug discoverers, developers and innovators are committed to applying advances in genetic medicine to help patients as quickly as possible. For more information visitbridgebio.comand follow us onLinkedIn,X,Facebook,Instagram, and YouTube.

BridgeBio Media Contact:Bubba Murarka, Executive Vice President, Corporate Developmentcontact@bridgebio.com(650)-789-8220

BridgeBio Investor Contact:Chinmay Shukla, Senior Vice President, Strategic Financeir@bridgebio.com

Frequently Asked Questions

What is the focus of BridgeBio Pharma?

BridgeBio Pharma focuses on discovering and delivering transformative medicines for genetic diseases.

When will the AHA Scientific Sessions 2025 take place?

The AHA Scientific Sessions 2025 will be held from November 7 to 10, 2025.

What are the main findings presented by BridgeBio?

BridgeBio will present findings on Acoramidis' effects on all-cause mortality and cardiovascular hospitalizations.

What adverse reactions were reported with Acoramidis?

Adverse reactions included diarrhea and upper abdominal pain, mostly mild and resolved without discontinuation.

What is the indication for Acoramidis?

Acoramidis is indicated for treating cardiomyopathy of transthyretin-mediated amyloidosis in adults.

Last updated: Nov 3, 2025