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Page 1 of 2 15 July 2001 Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder To Company Name/Scheme Alterity Therapeutics Limited ACN/ARSN 080 699 065 1. Details of substantial

Key Takeaway: The Bank of New York Mellon Corporation (BNYMC) has reported a change in its substantial holding in Alterity Therapeutics Limited (ATHE). As of July 24, 2025, BNYMC holds approximately 29.29% of the voting shares, an increase from 28.04%. The details of the changes in the number of shares held include various deposits and transfers made over the period from July 7 to July 24, 2025. This report is in compliance with the Corporations Act 2001 and outlines the nature of interests held by BNYMC and its associates.

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Full Press Release Details

604 Page 1 of 2 15 July
Corporations Act 2001
Notice of change of interests of
To Company Name/Scheme Alterity Therapeutics Limited
ACN/ARSN 080 699 065
Name The Bank of New York Mellon Corporation (BNYMC) and each Group Entity listed in Annexure A (Group Entity), (together BNYMC Group)
ACN/ARSN (if applicable)
There was a change in the interests of the substantial holder on 24 / July / 2025
The previous notice was given to the company on 04 / July / 2025
The previous notice was dated 03 / July / 2025
The total number of votes attached to all the voting shares in the
company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required,
and when now required, to give a substantial holding notice to the company or scheme, are as follows:
Class of securities (4) Previous notice Present notice
Person's votes Voting power (5) Person's votes Voting power (5)
Ordinary shares 2,559,017,317 28.04% 2,697,212,317* 29.29%*
*See Note 1 in Annexure C
Particulars of each change in, or change in the nature of, a relevant
interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last
required to give a substantial holding notice to the company or scheme are as follows:
Date of change Person whose relevant interest changed Nature of change (6) Consideration given in relation to change (7) Class and number of securities affected Person's votes affected
See Annexure B
Particulars of each relevant interest of the substantial
holder in voting securities after the change are as follows:
Holder of relevant interest Registered holder of securities Person entitled to be registered as holder (8) Nature of relevant interest (6) Class and number of securities Person's votes
See Annexure C
604 Page 2 of 2 15 July
The persons who have become associates (2) of, ceased to be associates
of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or
scheme are as follows:
Name and ACN/ARSN (if applicable) Nature of association
BNYMC and each Group Entity Each Group Entity is an associate of BNYMC pursuant to section 12(2)(a) of the Corporations Act 2001 (Cth) as each entity is directly or indirectly owned and controlled by BNYMC.
The addresses of persons named in this form are as follows:
Name Address
The Bank of New York Mellon Corporation 240 Greenwich Street, New York, NY 10286 USA
Each Group Entity 240 Greenwich Street, New York, NY 10286 USA
print name Andrew Weiser capacity Attorney-In-Fact
sign here /s/ Andrew Weiser date 25/July/2025
is Annexure A of 1 page referred to in Form 604 Notice of Change
of Interests of Substantial Holder given by The Bank of New York
Corporation and its related bodies corporate.
The Bank of New York Mellon Corporation
is the ultimate parent company of a corporate group comprised of a large number of operating and holding companies. Details of the entities
directly owned and controlled by The Bank of New York Mellon Corporation are listed below.
print name Andrew Weiser capacity Attorney-In-Fact
sign here /s/ Andrew Weiser date 25/July/2025
This is Annexure B of 1 page referred to in Form 604 Notice of Change
of Interests of Substantial Holder given by The Bank of New York Mellon Corporation and its related bodies corporate
Changes in relevant interests
Date of change Person whose relevant interest changed Nature of Change Consideration given in relation to change Class and number of securities affected (Ordinary Shares) Person's votes affected
7-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 4,230,000 4,230,000
9-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 12,000,000 12,000,000
10-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 3,000,000 3,000,000
11-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 6,385,800 6,385,800
14-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 9,600,000 9,600,000
15-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 3,846,000 3,846,000
15-Jul-2025 The Bank of New York Mellon Transfer out of securities N/A (4,992,600) (4,992,600)
21-Jul-2025 The Bank of New York Mellon Transfer out of securities N/A (12,000,000) (12,000,000)
22-Jul-2025 The Bank of New York Mellon Transfer out of securities N/A (27,600,000) (27,600,000)
23-Jul-2025 The Bank of New York Mellon Transfer out of securities N/A (5,274,000) (5,274,000)
24-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 160,999,800 160,999,800
24-Jul-2025 The Bank of New York Mellon Transfer out of securities N/A (12,000,000) (12,000,000)
Print Name - Andrew Weiser Capacity - Attorney-In-Fact
Sign Here /s/ Andrew Weiser Date - 25 July 2025
is Annexure C of 2 pages referred to in Form 604 Notice of
Change of Interests of Substantial Holder given by The Bank of New
Corporation and its related bodies corporate
Holder of relevant interest Nature of relevant interest Class and number of securities
The Bank of New York Mellon ( BNYM ) Remote Interest Held Under Deposit Agreement Relevant interest under section 608(1)(c) of the Corporations Act 2001 (Cth) arising from BNYM having the limited power to dispose of, or control the exercise of a power to dispose of, securities deposited with or held by BNYM (or its custodian or agent) in its capacity as depositary administering an ADR program for Alterity Therapeutics Limited (Company) under the Deposit Agreement dated January 2, 2008 between the Company, holders of American depositary receipts (ADRs) and BNYM (Deposit Agreement). [*See Note 1 below]. 2,697,211,348 ordinary shares
BNYMC Group (other than BNYM) Relevant interest under section 608(3)(a) and/or section 608(3)(b) of the Corporations Act 2001 (Cth) being a relevant interest held through a body corporate (namely BNYM) in which the voting power of each other entity in the BNYMC Group is above 20%, or that each other entity in the BNYMC Group controls. [*See Note 1 and Note 2 below] 2,697,211,348 ordinary shares
Pershing LLC Relevant interest under sections 608(1) of the Corporations Act 2001 (Cth) arising from Pershing LLC being the registered owner of the securities. 969 ordinary shares
BNYMC Group (other than Pershing LLC) Relevant interest under section 608(3)(a) and/or section 608(3)(b) of the Corporations Act 2001 (Cth) being a relevant interest held through a body corporate (namely Pershing LLC) in which the voting power of each other entity in the BNYMC Group is above 20%, or that each other entity in the BNYMC Group controls. [*See Note 2 below] 969 ordinary shares
print name Andrew Weiser capacity Attorney-In-Fact
sign here /s/ Andrew Weiser date 25/July/2025

Frequently Asked Questions

What change occurred on 24 July 2025?

On 24 July 2025, the substantial holder, BNYMC, reported an increase in voting shares.

What are the total votes after the change?

After the change, the total votes held rose to 2,697,212,317, reflecting 29.29%.

Who represented BNYMC in this notice?

Andrew Weiser, acting as Attorney-In-Fact, represented BNYMC in this notice.

What role does BNYM play in the holding structure?

BNYM acts as the depositary administering the ADR program for Alterity Therapeutics.

How many ordinary shares are held by BNYM?

BNYM holds a relevant interest in 2,697,211,348 ordinary shares.

Last updated: Jul 28, 2025