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Page 1 of 2 15 July 2001 Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder To Company Name/Scheme Alterity Therapeutics Limited ACN/ARSN 080 699 065 1. Details of substantial

Key Takeaway: The Bank of New York Mellon Corporation has announced a change in its substantial holding in Alterity Therapeutics Limited, increasing its voting power from 27.03% to 28.04%. This change took effect on July 3, 2025, following a series of deposits of securities leading to the increase in the total number of shares held. The previous notice regarding its shareholding was issued on May 22, 2025.

Market Sentiment Analysis

POSITIVE FACTORS

  • The Bank of New York Mellon Corporation increased its voting power in Alterity Therapeutics.
  • BNYMC group's relevant interest in ordinary shares is now substantial.
  • The changes in interest reflect ongoing investment activity.

Full Press Release Details

604 Page 1 of 2 15 July
Corporations Act 2001
Notice of change of interests of
To Company Name/Scheme Alterity Therapeutics Limited
ACN/ARSN 080 699 065
Details of substantial holder (1)
Name The Bank of New York Mellon Corporation (BNYMC) and each Group Entity listed in Annexure A (Group Entity), (together BNYMC Group)
ACN/ARSN (if applicable)
There was a change in the interests of the substantial holder on 03 / July / 2025
The previous notice was given to the company on 22 / May / 2025
The previous notice was dated 21 / May / 2025
Previous and present voting power
The total number of votes attached to all the voting shares in the
company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required,
and when now required, to give a substantial holding notice to the company or scheme, are as follows:
Class of securities (4) Previous notice Present notice
Person's votes Voting power (5) Person's votes Voting power (5)
Ordinary shares 2,466,998,317 27.03% 2,559,017,317* 28.04%*
*See Note 1 in Annexure C
Changes in relevant interests
Particulars of each change in, or change in the nature of, a relevant
interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last
required to give a substantial holding notice to the company or scheme are as follows:
Date of change Person whose relevant interest changed Nature of change (6) Consideration given in relation to change (7) Class and number of securities affected Person's votes affected
See Annexure B
Present relevant interests
Particulars of each relevant interest of the substantial
holder in voting securities after the change are as follows:
Holder of relevant interest Registered holder of securities Person entitled to be registered as holder (8) Nature of relevant interest (6) Class and number of securities Person's votes
See Annexure C
604 Page 2 of 2 15 July
Changes in association
The persons who have become associates (2) of, ceased to be associates
of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or
scheme are as follows:
Name and ACN/ARSN (if applicable) Nature of association
BNYMC and each Group Entity Each Group Entity is an associate of BNYMC pursuant to section 12(2)(a) of the Corporations Act 2001 (Cth) as each entity is directly or indirectly owned and controlled by BNYMC.
The addresses of persons named in this form are as follows:
Name Address
The Bank of New York Mellon Corporation 240 Greenwich Street, New York, NY 10286 USA
Each Group Entity 240 Greenwich Street, New York, NY 10286 USA
print name Kevin Lockhart capacity Attorney-In-Fact
sign here /s/ Kevin Lockhart date 04 / July / 2025
is Annexure A of 1 page referred to in Form 604 Notice of Change
of Interests of Substantial Holder given by The Bank of New York
Corporation and its related bodies corporate.
The Bank of New York Mellon Corporation
is the ultimate parent company of a corporate group comprised of a large number of operating and holding companies. Details of the entities
directly owned and controlled by The Bank of New York Mellon Corporation are listed below.
print name Kevin Lockhart capacity Attorney-In-Fact
s ign here /s/ Kevin Lockhart date 04/July/2025
This is Annexure B of 1 page referred to in Form 604 Notice of Change
of Interests of Substantial Holder given by The Bank of New York Mellon Corporation and its related bodies corporate
Changes in relevant interests
Date of change Person whose relevant interest changed Nature of Change Consideration given in relation to change Class and number of securities affected (Ordinary Shares) Person's votes affected
27-May-2025 The Bank of New York Mellon Deposit of securities N/A 9,600,000 9,600,000
2-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 2,659,200 2,659,200
11-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 21,5646000 21,564,600
12-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 3,000,000 3,000,000
13-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 1,800,000 1,800,000
17-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 7,087,200 7,087,200
20-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 9,000,000 9,000,000
24-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 13,500,000 13,500,000
26-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 1,200,000 1,200,000
27-Jun-2025 The Bank of New York Mellon Deposit of securities N/A 9,000,000 9,000,000
1-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 7,608,000 7,608,000
2-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 3,000,000 3,000,000
3-Jul-2025 The Bank of New York Mellon Deposit of securities N/A 3,000,000 3,000,000
Print Name - Kevin Lockhart Capacity - Attorney-In-Fact
Sign Here /s/ Kevin Lockhart Date - 04 July 2025
This is Annexure C of 2 pages referred to in Form 604 Notice
Change of Interests of Substantial Holder given by The Bank of New
York Mellon Corporation and its related bodies corporate
Present relevant interests
Holder of relevant interest Nature of relevant interest Class and number of securities
The Bank of New York Mellon ( BNYM ) Remote Interest Held Under Deposit Agreement Relevant interest under section 608(1)(c) of the Corporations Act 2001 (Cth) arising from BNYM having the limited power to dispose of, or control the exercise of a power to dispose of, securities deposited with or held by BNYM (or its custodian or agent) in its capacity as depositary administering an ADR program for Alterity Therapeutics Limited (Company) under the Deposit Agreement dated January 2, 2008 between the Company, holders of American depositary receipts (ADRs) and BNYM (Deposit Agreement). [*See Note 1 below]. 2,559,016,348 ordinary shares
BNYMC Group (other than BNYM) Relevant interest under section 608(3)(a) and/or section 608(3)(b) of the Corporations Act 2001 (Cth) being a relevant interest held through a body corporate (namely BNYM) in which the voting power of each other entity in the BNYMC Group is above 20%, or that each other entityin the BNYMC Group controls. [*See Note 1 and Note 2 below] 2,559,016,348 ordinary shares
Pershing LLC Relevant interest under sections 608(1) of the Corporations Act 2001 (Cth) arising from Pershing LLC being the registered owner of the securities. 969 ordinary shares
BNYMC Group (other than Pershing LLC) Relevant interest under section 608(3)(a) and/or section 608(3)(b) of the Corporations Act 2001 (Cth) being a relevant interest held through a body corporate (namely Pershing LLC) in which the voting power of each other entity in the BNYMC Group is above 20%, or that each other entity in the BNYMC Group controls. [*See Note 2 below] 969 ordinary shares
print name Kevin Lockhart capacity Attorney-In-Fact
sign here /s/ Kevin Lockhart date 04/July/2025

Frequently Asked Questions

Who is the substantial holder reported in the notice?

The substantial holder is The Bank of New York Mellon Corporation (BNYMC) and its Group Entities.

What was the date of the last change in interests?

The last change in interests occurred on July 3, 2025.

How many voting shares does BNYMC currently hold?

BNYMC currently holds 2,559,017,317 ordinary shares, representing 28.04% voting power.

What type of interest does BNYM hold?

BNYM holds a remote interest under a Deposit Agreement with Alterity Therapeutics.

What is the significance of the Deposit Agreement?

The Deposit Agreement allows BNYM to control the exercise of voting rights for deposited securities.

Last updated: Jul 7, 2025