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Alterity Therapeutics Filed Form 20-F and XBRL data with the SEC MELBOURNE, AUSTRALIA AND SAN FRANCISCO, USA - 2 September 2025: Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) ("Alterity" or "the Company"), a biotechnolo

Key Takeaway: Alterity Therapeutics has filed its Annual Report on Form 20-F with the US SEC, containing audited financial statements for the year ending June 30, 2025. The report highlights ongoing efforts in developing disease-modifying treatments for neurodegenerative diseases, particularly focusing on the drug ATH434 for Parkinson's-related conditions. Despite the positive clinical trial outcomes, the company faces several risks related to drug development, financing, and regulatory approvals.

Market Sentiment Analysis

POSITIVE FACTORS

  • Alterity Therapeutics filed its Annual Report on Form 20-F, enhancing transparency for investors.
  • The company demonstrated clinically meaningful efficacy for ATH434 in clinical trials.
  • Alterity is focused on developing treatments for neurodegenerative diseases, which is a high-demand area.

CONCERNS & RISKS

  • Forward-looking statements indicate potential risks such as difficulties in financing and regulatory approval.
  • Uncertainties regarding therapeutic efficacy and side effects of drug compounds like ATH434 could hinder progress.
  • Potential challenges in securing patent protection for intellectual property create additional risks.

Full Press Release Details

Alterity Therapeutics Filed Form 20-F and XBRL
MELBOURNE, AUSTRALIA AND SAN FRANCISCO, USA
- 2 September 2025: Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) ("Alterity" or "the Company"), a
biotechnology company dedicated to developing disease modifying treatments for neurodegenerative diseases, today announced that it
has filed its Annual Report on Form 20-F containing audited consolidated financial statements for the year ended June 30, 2025 with the
US Securities and Exchange Commission (SEC). The annual report is available on the company website https://alteritytherapeutics.com.
Shareholders may receive a hard copy of the annual report free of charge upon request.
The company has also filed the XBRL interactive
data with the SEC and this is available via the company website at https://alteritytherapeutics.com/investor-overview/press-releases/.
About Alterity Therapeutics Limited
Alterity Therapeutics is a clinical stage biotechnology
company dedicated to creating an alternate future for people living with neurodegenerative diseases. The Company is initially focused
on developing disease modifying therapies in Parkinson's disease and related disorders. Alterity has demonstrated clinically meaningful
efficacy for its lead asset, ATH434, in a randomized, double-blind, placebo-controlled Phase 2 clinical trial in participants with Multiple
System Atrophy (MSA), a rare and rapidly progressive Parkinsonian disorder. ATH434 recently reported positive data in its open label
Phase 2 clinical trial in advanced MSA. In addition, Alterity has a broad drug discovery platform generating patentable chemical compounds
to treat the underlying pathology of neurological diseases. The Company is based in Melbourne, Australia, and San Francisco, California,
USA. For further information please visit the Company's website at www.alteritytherapeutics.com.
Authorisation & Additional information
This announcement was authorized by David Stamler, CEO of Alterity
Therapeutics Limited.
Investor and Media Contacts:
Forward Looking Statements
This press release contains "forward-looking
statements" within the meaning of section 27A of the Securities Act of 1933 and section 21E of the Securities Exchange Act of 1934.
The Company has tried to identify such forward-looking statements by use of such words as "expects," "intends," "hopes,"
"anticipates," "believes," "could," "may," "evidences" and "estimates," and
other similar expressions, but these words are not the exclusive means of identifying such statements.
Important factors that could cause actual results
to differ materially from those indicated by such forward-looking statements are described in the sections titled "Risk Factors"
in the Company's filings with the SEC, including its most recent Annual Report on Form 20-F as well as reports on Form 6-K, including,
but not limited to the following: statements relating to the Company's drug development program, including, but not limited to the initiation,
progress and outcomes of clinical trials of the Company's drug development program, including, but not limited to, ATH434, and any other
statements that are not historical facts. Such statements involve risks and uncertainties, including, but not limited to, those risks
and uncertainties relating to the difficulties or delays in financing, development, testing, regulatory approval, production and marketing
of the Company's drug components, including, but not limited to, ATH434, the ability of the Company to procure additional future
sources of financing, unexpected adverse side effects or inadequate therapeutic efficacy of the Company's drug compounds, including, but
not limited to, ATH434, that could slow or prevent products coming to market, the uncertainty of obtaining patent protection for the Company's
intellectual property or trade secrets, the uncertainty of successfully enforcing the Company's patent rights and the uncertainty
of the Company freedom to operate.
Any forward-looking statement made by us in
this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake
no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as
a result of new information, future developments or otherwise.

Frequently Asked Questions

What is the main focus of Alterity Therapeutics?

Alterity Therapeutics focuses on developing disease-modifying treatments for neurodegenerative diseases.

When did Alterity file its Form 20-F?

Alterity filed its Form 20-F on September 2, 2025.

How can shareholders obtain the annual report?

Shareholders can request a hard copy of the annual report free of charge.

What is ATH434 used for?

ATH434 is developed for treating Multiple System Atrophy, a progressive Parkinsonian disorder.

Where is Alterity Therapeutics based?

Alterity Therapeutics is based in Melbourne, Australia, and San Francisco, USA.

Last updated: Sep 2, 2025