Full Press Release Details
Aprea Therapeutics Reports Second Quarter 2023 Financial Results and
Provides Update on Business Operations
DOYLESTOWN, PA, August 10, 2023 (GLOBE NEWSWIRE) - Aprea Therapeutics, Inc. (Nasdaq: APRE) ("Aprea", or the "Company"), a clinical stage biopharmaceutical company focused on precision oncology through synthetic lethality, today reported financial results for the three and six months ended June 30, 2023 and provided a business update
"We continue to execute across all our programs, with notable progress in enrollment in our lead Phase 1/2a dose escalation study with ATRN-119, our ATR inhibitor for the treatment of advanced solid tumors and anticipate initial preliminary data in the fourth quarter 2023," said Oren Gilad, Ph.D., President and Chief Executive Officer of Aprea. "Our IND enabling studies for ATRN-1051, our WEE1 inhibitor, continue to be on track, and we continue to anticipate filing an IND by the end of the year. Our strong balance sheet continues to support our strategy and plans through our near-term milestones in both our ATR and WEE1 programs, with a cash runway into the fourth quarter of 2024. We look forward to providing more updates as we make progress throughout the rest of the year."
Key Business and Financial Updates
Select Financial Results for the Second Quarter ended June 30, 2023
Atrin which was accounted for as an asset acquisition. The acquisition cost allocated to acquired IPR&D with no alternative future use was recorded as an expense as of the closing date in May 2022.
About Aprea Therapeutics, Inc.
Aprea Therapeutics, Inc. is a clinical stage biopharmaceutical company headquartered in Doylestown, Pennsylvania, focused on precision oncology through synthetic lethality. The Company's lead program is ATRN-119, a clinical-stage small molecule ATR inhibitor being developed for solid tumor indications. Our WEE1 inhibitor is being advanced to IND submission. For more information, please visit the company website at www.aprea.com.
The Company may use, and intends to use, its investor relations website at https://ir.aprea.com/ as a means of disclosing material nonpublic information and for complying with its disclosure obligations under Regulation FD.
Forward Looking Statement
Certain information contained in this press release includes "forward-looking statements", within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, related to our study analyses, clinical trials, regulatory submissions, and projected cash position. We may, in some cases use terms such as "future," "predicts," "believes," "potential," "continue," "anticipates," "estimates," "expects," "plans," "intends," "targeting," "confidence," "may," "could," "might," "likely," "will," "should" or other words that convey uncertainty of the future events or outcomes to identify these forward-looking statements. Our forward-looking statements are based on current beliefs and expectations of our management team and on information currently available to management that involve risks, potential changes in circumstances, assumptions, and uncertainties. All statements contained in this press release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, including timing considerations and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations. Any or all of the forward-looking statements may turn out to be wrong or be affected by inaccurate assumptions we might make or by known or unknown risks and uncertainties. These forward-looking statements are subject to risks and uncertainties including, without limitation, risks related to the success, timing and cost of our ongoing clinical trials and anticipated clinical trials for our current product candidates, including statements regarding the timing of initiation, pace of enrollment and completion of the trials, futility analyses, presentations at conferences and data reported in an abstract, and receipt of interim or preliminary results (including, without limitation, any preclinical results or data), which are not necessarily indicative of the final results of our ongoing clinical trials, and the other risks, uncertainties, and other factors described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the U.S. Securities and Exchange Commission. For all these reasons, actual results and developments could be materially different from those expressed in or implied by our forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which are made only as of the date of this press release. We undertake no obligation to update such forward-looking statements for any reason, except as required by law.
Source: Aprea Therapeutics, Inc.
Aprea Therapeutics, Inc.
Condensed Consolidated Balance Sheets
| June 30, | December 31, | |||||
| 2023 | 2022 | |||||
| Assets | ||||||
| Current assets: | ||||||
| Cash and cash equivalents | $ | 27,685,131 | $ | 28,786,647 | ||
| Prepaid expenses and other current assets | 953,670 | 1,366,859 | ||||
| Total current assets | 28,638,801 | 30,153,506 | ||||
| Property and equipment, net | 1,687 | 2,321 | ||||
| Restricted cash | 40,180 | - | ||||
| Total assets | $ | 28,680,668 | $ | 30,155,827 | ||
| Liabilities and Stockholders' Equity | ||||||
| Current liabilities: | ||||||
| Accounts payable | $ | 1,131,197 | $ | 842,754 | ||
| Accrued expenses | 2,819,624 | 2,358,332 | ||||
| Total current liabilities | 3,950,821 | 3,201,086 | ||||
| Total liabilities | 3,950,821 | 3,201,086 | ||||
| Commitments and contingencies | ||||||
| Series A convertible preferred stock, $0.001 par value, 40,000,000 shares authorized; 56,227 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively. | 1,311,063 | 1,311,063 | ||||
| Stockholders' equity: | ||||||
| Common stock, $0.001 par value, 400,000,000 shares authorized, 3,731,571 and 2,655,269 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively. | 3,731 | 2,655 | ||||
| Additional paid-in capital | 335,485,317 | 330,060,836 | ||||
| Accumulated other comprehensive loss | (10,634,872) | (10,623,408) | ||||
| Accumulated deficit | (301,435,392) | (293,796,405) | ||||
| Total stockholders' equity | 23,418,784 | 25,643,678 | ||||
| Total liabilities and stockholders' equity | $ | 28,680,668 | $ | 30,155,827 |
Aprea Therapeutics, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
| Three Months Ended June 30, | Six Months Ended June 30, | |||||||||||
| 2023 | 2022 | 2023 | 2022 | |||||||||
| Grant revenue | $ | 249,688 | $ | - | $ | 249,688 | $ | - | ||||
| Operating expenses: | ||||||||||||
| Research and development | 2,202,657 | 6,811,609 | 3,459,199 | 10,901,186 | ||||||||
| General and administrative | 1,698,712 | 15,633,738 | 5,064,673 | 19,619,036 | ||||||||
| Acquired in-process research and development | - | 76,020,184 | - | 76,020,184 | ||||||||
| Total operating expenses | 3,901,369 | 98,465,531 | 8,523,872 | 106,540,406 | ||||||||
| Loss from operations | (3,651,681) | (98,465,531) | (8,274,184) | (106,540,406) | ||||||||
| Other income: | ||||||||||||
| Interest income, net | 336,221 | 52,491 | 592,631 | 54,462 | ||||||||
| Foreign currency gain | 56,363 | 154,566 | 42,566 | 290,777 | ||||||||
| Total other income | 392,584 | 207,057 | 635,197 | 345,239 | ||||||||
| Net loss | $ | (3,259,097) | $ | (98,258,474) | $ | (7,638,987) | $ | (106,195,167) | ||||
| Other comprehensive loss: | ||||||||||||
| Foreign currency translation | (73,420) | 157,655 | (11,464) | 92,150 | ||||||||
| Total comprehensive loss | (3,332,517) | (98,100,819) | (7,650,451) | (106,103,017) | ||||||||
| Net loss per share attributable to common stockholders, basic and diluted | $ | (0.87) | $ | (86.72) | $ | (2.18) | $ | (95.31) | ||||
| Weighted-average common shares outstanding, basic and diluted | 3,731,571 | 1,133,092 | 3,497,329 | 1,114,189 |