Full Press Release Details
Therapeutics Announces First Patient Dosed in Part B of Phase 2 APEX Trial of APG777 in Patients with Moderate-to-Severe Atopic Dermatitis
of Part A completed ahead of schedule and exceeded enrollment target with 123 patients enrolled
A 16-week proof-of-concept data anticipated in mid-2025
FRANCISCO and BOSTON, February 3, 2025 -- Apogee Therapeutics, Inc., (Nasdaq: APGE), a clinical-stage biotechnology company advancing
novel biologics with potential for differentiated efficacy and dosing in the largest inflammatory and immunology (I&I) markets, including
for the treatment of atopic dermatitis (AD), asthma, chronic obstructive pulmonary disease (COPD), eosinophilic esophagitis (EoE) and
other I&I indications, today announced the first patient has been dosed in the Part B portion of the Phase 2 APEX clinical trial
of APG777 in patients with moderate-to-severe AD, as well as enrollment completion in the Part A portion of the trial.
for the Phase 2 Part A trial of APG777 surpassed the approximately 110 patient target ahead of schedule, driven by strong patient and
investigator enthusiasm, underscoring the potential of APG777 to address the need for safe, effective treatment options that reduce injection
burden and provide better disease control for patients with AD and other I&I conditions," said Carl Dambkowski, M.D., Chief
Medical Officer of Apogee. "Positive results from our Phase 1 healthy volunteer trial enabled us to design this Phase 2 trial whereby
APG777 is modeled to exceed lebrikizumab exposures by ~30-40% with potential for improved clinical responses, as well as approximately
half the number of injections during induction and ~70-90% fewer injections in maintenance compared to currently available therapies.
Our uniquely designed Phase 2 trial allowed us to seamlessly transition from completing enrollment in Part A to enrolling Part B within
one week, streamlining the clinical development process and potentially enabling us to bring APG777 to patients sooner."
is a Phase 2 randomized, placebo-controlled clinical trial evaluating APG777, a novel, subcutaneous (SQ) extended half-life monoclonal
antibody (mAb) targeting IL-13 - a critical cytokine in inflammation and a primary driver of AD, in patients with moderate-to-severe
AD. The trial was designed to combine the typical Phase 2a and 2b portions of a clinical trial into a single protocol. Part A exceeded
expected enrollment with 123 patients randomized 2:1 to APG777 versus placebo; patients assigned to APG777 received induction regimen
dosing of 720mg at weeks 0 and 2, followed by 360mg at weeks 4 and 12 and the trial has greater than 90% power for the primary endpoint.
Patients benefiting from treatment will continue to APG777 maintenance dosing, which will evaluate 3- or 6-month dosing. Part B is a
placebo-controlled dose optimization with approximately 280 patients randomized 1:1:1:1 to high, medium, or low dose APG777 versus placebo
and the first patient in Part B have now been dosed. The primary endpoint of each part of the study is mean percentage change in EASI
score from baseline at week 16. Secondary endpoints include EASI-75 and IGA 0/1 at week 16.
is currently in clinical development as a monotherapy for AD with several proof-of-concept anticipated readouts in 2025 and 2026, including
Part A 16-week induction data in mid-2025 and maintenance data in the first half of 2026 as well as Part B 16-week data in the second
half of 2026. Apogee plans to advance development of APG777 in expansion indications by initiating a Phase 1b trial in asthma in the
first half of 2025, followed by a Phase 2b trial in asthma in the second half of 2025, and launching a Phase 2 trial in EoE in 2026.
In addition, Apogee plans to evaluate APG777 in combination with other investigational therapies within Apogee's pipeline to potentially
enable greater efficacy and improved safety for I&I conditions. Apogee plans to initiate its first combination study, a Phase 1b
trial of APG777 and APG990, a novel, SQ, half-life extended mAb targeting OX40L, in 2025. This combination study is designed to evaluate
the safety, PK, PD and efficacy against DUPIXENT in patients with moderate-to-severe AD, with readout expected in the second half of
is a novel, subcutaneous half-life extended monoclonal antibody targeting IL-13 for the potential treatment of AD. In head-to-head preclinical
studies, APG777 showed equivalent or better potency to lebrikizumab in the inhibition of IL-13 signaling. APG777 Phase 1 trial data out
to 12 months demonstrated a half-life of 77 days, a consistent safety and favorable PD profile showing near complete inhibition of pSTAT6
for up to 12 months after a single administration and sustained TARC inhibition. AD is a chronic inflammatory skin disorder with an estimated
population of 82 million people worldwide afflicted with moderate-to-severe AD. Based on initial clinical data, the company plans to
initiate a Phase 1b and 2b trial in asthma, a Phase 2 trial in EoE and plans to further evaluate opportunities to develop APG777 for
other I&I indications, including alopecia areata, chronic rhinosinusitis with nasal polyps, chronic spontaneous urticaria, and prurigo
Therapeutics is a clinical-stage biotechnology company advancing novel biologics with potential for differentiated efficacy and dosing
in the largest I&I markets, including for the treatment of AD, asthma, COPD, EoE and other I&I indications. Apogee's antibody
programs are designed to overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating
advanced antibody engineering to optimize half-life and other properties. APG777, the company's most advanced program, is being
initially developed for the treatment of AD, which is the largest and one of the least penetrated I&I markets. With four validated
targets in its portfolio, Apogee is seeking to achieve best-in-class efficacy and dosing through monotherapies and combinations of its
novel antibodies. Based on a broad pipeline and depth of expertise, the company believes it can deliver value and meaningful benefit
to patients underserved by today's standard of care. For more information, please visit https://apogeetherapeutics.com.
statements in this press release may constitute "forward-looking statements" within the meaning of the federal securities
laws, including, but not limited to, statements regarding: Apogee's plans for its current and future product candidates and programs,
particularly APG777; its plans for current and future clinical trials, including trial design and expected timing; expected timing for
release of the initial Part A data from Apogee's Phase 2 clinical trial of APG777 in AD; the potential clinical benefit, dosing
schedule and half-life of APG777; plans for Apogee's other product candidates, and any other potential programs, including combination
therapies. Words such as "may," "might," "will," "objective," "intend," "should,"
"could," "can," "would," "expect," "believe," "design," "estimate,"
"predict," "potential," "develop," "plan" or the negative of these terms, and similar
expressions, or statements regarding intent, belief, or current expectations, are forward-looking statements. While Apogee believes these
forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements, which are based
on information available to the company on the date of this release. These forward-looking statements are based upon current estimates
and assumptions and are subject to various risks and uncertainties (including, without limitation, those set forth in Apogee's
filings with the U.S. Securities and Exchange Commission (the SEC)), many of which are beyond the company's control and subject
to change. Actual results could be materially different. Risks and uncertainties include: global macroeconomic conditions and related
volatility, expectations regarding the initiation, progress, and expected results of Apogee's preclinical studies, clinical trials
and research and development programs; expectations regarding the timing, completion and outcome of Apogee's clinical trials; the
unpredictable relationship between preclinical study results and clinical study results; the timing or likelihood of regulatory filings
and approvals; liquidity and capital resources; and other risks and uncertainties identified in Apogee's Annual Report on Form
10-K for the year ended December 31, 2023, filed with the SEC on March 5, 2024, Quarterly Report on 10-Q for the quarterly period ended
September 30, 2024, filed with the SEC on November 12, 2024, and subsequent disclosure documents we may file with the SEC. Apogee claims
the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. Apogee
expressly disclaims any obligation to update or alter any statements whether as a result of new information, future events or otherwise,
except as required by law.