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Annovis CEO to Present on Multi-Protein Model of Alzheimer's Disease at Fierce Biotech Week 2026

Key Takeaway: Annovis Bio's CEO, Maria Maccecchini, will present at Fierce Biotech Week 2026, discussing the multi-protein model of Alzheimer's disease. The presentation will highlight the importance of addressing multiple neurotoxic proteins in disease progression, contrasting with the traditional single-protein focus. Annovis's lead drug, buntanetap, is currently in a pivotal Phase 3 trial.

Market Sentiment Analysis

POSITIVE FACTORS

  • Annovis is advancing its lead drug candidate, buntanetap, in a pivotal Phase 3 trial.
  • The CEO's presentation emphasizes a multi-protein approach to Alzheimer's treatment.
  • Encouraging clinical benefits and biomarker data support the drug's efficacy.

Full Press Release Details

MALVERN, Pa., May 07, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), today announced that Maria Maccecchini, Ph.D., President and CEO, will present atFierce Biotech Week 2026taking place in Boston, May 12-14, 2026.

Presentation Details:

• Title: "The Multi-Protein Reality of Alzheimer's Disease: What the Science Has Known for Decades and What the Field Has Yet to Accept"
• Presenter: Maria Maccecchini, Ph.D., President and CEO
• Date: Wednesday, May 13, 2026
• Time: 1:40 PM - 2:05 PM
• Location: Picasso 4&5
The presentation will trace the scientific foundation for understanding AD as a disease driven by multiple neurotoxic aggregating proteins and examine the historical gap between that evidence and the field's reliance on a single-protein approach. Dr. Maccecchini will make the case supporting the importance of the full spectrum of neurotoxic proteins – including amyloid, tau, alpha-synuclein, TDP-43, and more – in disease progression, which are not only backed by decades of scientific data but also represent a promising path forward for the AD drug development.
"Alzheimer's disease has never been a one-protein problem, and overreliance on amyloid as the sole driver of the disease has come at a cost, hindering progress for alternative therapeutic candidates," said Maria Maccecchini, Ph.D., President and CEO. "Annovis’ program is built exactly on the premise that simultaneous reduction of the overexpression of several aggregating proteins interrupts the toxic cascade and improves the health of nerve cells. Our lead drug buntanetap, a translational inhibitor of these proteins, has already shown meaningful clinical benefits supported by encouraging biomarker data, and is now in a pivotal Phase 3 clinical trial."
The presentation will be followed by a Q&A discussion and is open to all participants.
Fierce Biotech Week 2026brings together leaders across R&D, clinical development, business development, and communications to confront the industry's most pressing challenges, from capital strategy and pipeline advancement to partnership formation and commercialization. With more than 100 biotech CEOs and founders, over 500 companies, and 15 top global pharmaceutical organizations represented, the event is built for the leaders driving consequential decisions.
About AnnovisHeadquartered in Malvern, Pennsylvania, Annovis Bio, Inc. (NYSE: ANVS) is a Phase 3 clinical-stage biotechnology company developing treatments for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). The Company's lead drug candidate, buntanetap (formerly posiphen), is an investigational once-daily oral therapy that inhibits the translation of multiple neurotoxic proteins, including APP and amyloid beta, tau, alpha-synuclein, and TDP-43, through a specific RNA-targeting mechanism of action. By addressing the underlying causes of neurodegeneration, Annovis aims to halt disease progression and improve cognitive and motor functions in patients. For more information, visitwww.annovisbio.comand follow us onLinkedIn,YouTube, andX.
Investor AlertsInterested investors and shareholders are encouraged to sign up for press releases and industry updates by registering for email alerts athttps://www.annovisbio.com/email-alerts.
Forward-Looking StatementsThis press release contains forward-looking statements under the Securities Act of 1933 and the Securities Exchange Act of 1934, as amended. Actual results may differ due to various risks and uncertainties, including those outlined in the Company’s SEC filings under “Risk Factors” in its Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. The Company undertakes no obligation to update forward-looking statements except as required by law.

Contact Information:Annovis Bio Inc.101 Lindenwood DriveSuite 225Malvern, PA 19355www.annovisbio.com

Investor Contact:Alexander Morin, Ph.D.Director, Strategic CommunicationsAnnovis Bioir@annovisbio.com

Frequently Asked Questions

What is the focus of Annovis's presentation at Fierce Biotech Week?

The presentation will focus on the multi-protein model of Alzheimer's disease.

When will Maria Maccecchini present at the event?

Maria Maccecchini will present on May 13, 2026, from 1:40 PM to 2:05 PM.

What is the lead drug candidate of Annovis Bio?

Annovis's lead drug candidate is buntanetap, targeting multiple neurotoxic proteins.

What is the significance of the multi-protein approach?

The multi-protein approach aims to address the complexity of Alzheimer's disease beyond a single-protein focus.

What stage is Annovis's drug candidate currently in?

Buntanetap is currently in a pivotal Phase 3 clinical trial.

Last updated: May 7, 2026