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INVESTOR EVENT Shaping the Future of Cardiovascular Care: Innovative
Technologies. Improved Outcomes.
Forward Looking Statements Forward Looking Statements Notice Regarding
Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements regarding AngioDynamics' expected future financial position,
results of operations, cash flows, business strategy, budgets, projected costs, capital expenditures, products, competitive positions, growth opportunities, plans and objectives of management for future operations, as well as statements that
include the words such as "expects," "reaffirms," "intends," "anticipates," "plans," "projects," "believes," "seeks," "estimates," "optimistic," or variations of such words and similar expressions, are forward-looking statements. These
forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties. Investors are cautioned that actual events or results may differ materially from AngioDynamics' expectations, expressed or
implied. Factors that may affect the actual results achieved by AngioDynamics include, without limitation, the scale and scope of the COVID-19 global pandemic, the ability of AngioDynamics to develop its existing and new products,
technological advances and patents attained by competitors, infringement of AngioDynamics' technology or assertions that AngioDynamics' technology infringes the technology of third parties, the ability of AngioDynamics to effectively compete
against competitors that have substantially greater resources, future actions by the FDA or other regulatory agencies, domestic and foreign health care reforms and government regulations, results of pending or future clinical trials, overall
economic conditions (including inflation, labor shortages and supply chain challenges including the cost and availability of raw materials), the results of on-going litigation, challenges with respect to third-party distributors or joint
venture partners or collaborators, the results of sales efforts, the effects of product recalls and product liability claims, changes in key personnel, the ability of AngioDynamics to execute on strategic initiatives, the effects of economic,
credit and capital market conditions, general market conditions, market acceptance, foreign currency exchange rate fluctuations, the effects on pricing from group purchasing organizations and competition, the ability of AngioDynamics to
obtain regulatory clearances or approval of its products, or to integrate acquired businesses, as well as the risk factors listed from time to time in AngioDynamics' SEC filings, including but not limited to its Annual Report on Form 10-K for
the year ended May 31, 2024. AngioDynamics does not assume any obligation to publicly update or revise any forward-looking statements for any reason. 2
AngioDynamics We are a dynamic, diversified medical technology company
committed to expanding treatment options and improving patient outcomes and quality of life by focusing on cardiovascular disease and cancer. Our execution strategy is built on innovative R&D, clinical and regulatory pathway expansion,
and customer centric sales performance. 523M diagnosed in 2020 ~19 million deaths2 19.3M diagnosed in 2020 ~10 million deaths5 Cardiovascular Disease Causes 1 in 3 Deaths Globally1 Cancer Causes 1 in 6 Deaths Globally3 3
AngioDynamics Summary AngioDynamics Summary 4
Venous Thromboembolism (VTE) $5.3B US TAM* AngioDynamics Cardiovascular
Portfolio Differentiated technologies and a comprehensive portfolio enable us to be a strong competitor within high growth Cardiovascular Disease market Cardiovascular Disease Cancer MINI STICK MAX Prostate Care $780M US
TAM* Peripheral Artery Disease (PAD) $760M US TAM* Med Tech Med Device * Management estimates & industry sources 5
AngioDynamics MedTech Revenue Contribution
~15% ~45% FY2021 $3.0B FY2023 $6.0B FY2025 $10.0B FY2018 $1.3B Total Addressable Markets Our demonstrated successful execution in portfolio optimization, clinical and regulatory expansion, and product introductions drives
growth Med TechGrowth Cardiovascular Growth 6
Cardiovascular Arterial With over 100,000 patients treated,6 the Auryon
Atherectomy System is projected in FY25 to exceed cumulative sales of $180M since its September 2020 launch 7 Served $500M M A R K E T D Y N A M I C S Auryon ~10%+ ABT 38% BSX 6% PHG 15% MDT 31% ANGO 10% Treat all levels of
calcification8-10 Indicated for in-stent restenosis Treats above and below the knee (inc. below the ankle) Portable, 110V outlet, low noise, touch screen Debulk in fewer passes Designed for hospital and lab8-10,13 Protective of vessel
wall10-12 Targeted biological reactions to address risk of perforations Built-in aspiration to address risk of embolization Ability to crack medial calcification21 Shock waves break severe calcification, including medial arterial
calcification Contributes to plaque modification that may help improve vessel compliance 8
P E R I P H E R A L A R T E R Y D I S E A S E (PAD) Aspiration capability and
indicated for ISR and to aspirate thrombus adjacent to stenosis Intuitive, Windows-based touch screen Small and portable (29 in x 13 in x 37 in) Lightweight (198.45 lbs.) 110 V power outlet No calibration and minimal warm up
time Ability to treat ISR, CTO, Calcified, Fibrotic, Thrombus and Soft Plaque lesions, ATK and BTK Foot pedal for hands-free activation Auryon's solid-state laser technology has three times more affinity for lesion material than vessel
walls and is capable of treating all lesions types ATK, BTK8-10 & ISR** 355 nm wavelength 10-25 ns pulse width 9
Auryon Platform Technology The Auryon System is designed to deliver an
optimized wavelength, pulse width, and amplitude to remove lesions while preserving vessel wall endothelium10,11,14 Wavelength (nm) The distance between 2 successive waves determines absorption rate and penetration depth Pulse width (ns)
The duration of each pulse determines level of diffusion Amplitude (mJ/mm2) The height of the wave determines power10,11,13 Why wavelength matters:15-18 Each type of tissue interacts differently with a given wavelength7,8 Longer
wavelengths are absorbed at shallower depths than shorter wavelengths, resulting in lower photon energies7,8,9,10 Importance of pulse width and amplitude15,17,19,20 Greater amplitude is achieved with shorter pulses, which can deposit
energy before thermal diffusion occurs10 To localize the effects to the target tissue without thermal damage, the energy delivered needs to be faster than the time it takes for the heat to diffuse E F F I C I E N T Does not require
calibration before each procedure May eliminate the need for multiple catheters for a single procedure Has the potential to debulk with minimal passes A D A P T A B L E Treats all infrainguinal lesions8,9,10 Treats infrainguinal lesions
both above and below knee Has the ability to crack arterial calcium and prep the vessel21 S M A R T Performs targeted biological reaction to address the risk of perforations22-23 Nonreactive to contrast media allowing simultaneous
ablation and observation of fluoroscopy images Includes built-in aspiration to address the risk of embolization* *2 and 2.35 mm catheters 10
Auryon Platform Technology The Auryon System's dual method of action: Micro-CT
Study21 Intimal Plaque/Calcium Debulking Works on removing different plaque morphologies, ATK - BTK and ISR Plaque/Calcium Modification Photomechanical shockwaves penetrate the medial wall to crack/modify plaque to bring pulsatility
(elasticity/compliance) back to aging vessels. Intimal Arterial Calcification Medial Arterial Calcification Mechanism #1 Mechanism #2 MODIFY REMOVE CRACK calcium & REMOVE plaque with ONE technology This study was performed on
cadavers, not on human subjects, and these results have not been validated in subsequent human research 11
Patient Enrollment Beginning Q2 CY 2025 RCT: 224 Patients Registry: ~1,500
Patients Initial European Experience in Coronary Artery Disease Auryon Platform Technology The Auryon System's technology has demonstrated safety and efficacy in PAD and presents an opportunity to expand into additional disease
states MicroCT Pre-Clinical Study Published Dec. 2023 Established Secondary Mechanism of Action Auryon w/ Angioplasty vs. Angioplasty alone Below The Knee (BTK) PATHFINDER Registry 12 Mo Published May 2024 Auryon BTK Prospective
Study Published May 2024 Promising Initial Study Results Safety, Efficacy & Versatility ~$900M US TAM* PMA Consideration P E R I P H E R A L A R T E R Y D I S E A S E (P A D) C O R O N A R Y A R T E R Y D I S E A S E (C A
VENOUS ARTERIAL The AngioVac Cannula is indicated for use as a venous drainage
cannula and for removal of fresh, soft thrombi or emboli during extracorporeal bypass for up to 6 hours. The AlphaVac cannula is indicated for the non-surgical removal of thrombi or emboli and aspiration of contrast media and other fluids
from the vasculature. It is intended for use in the venous system and for the treatment of Pulmonary Embolism
Cardiovascular Venous Venous Thromboembolism (VTE) represents an attractive,
high growth, underpenetrated market opportunity TAM $6B PE $3B DVT $3B Right Heart $120M Deep Vein Thrombosis (DVT) Mechanical Thrombectomy is estimated to have penetrated ~15% of the TAM 22 Mechanical Thrombectomy is expected to
grow ~20% in 202523 M A R K E T D Y N A M I C S Growth is driven by rising intravenous drug abuse, an aging population, and increased pacemaker prevalence More interventionalists embrace percutaneous techniques and the structural heart
market is expanding Right Heart Pulmonary Embolism (PE) Mechanical Thrombectomy is estimated to have penetrated ~25% of the TAM 22 Mechanical Thrombectomy is expected to grow ~16% in 2025 23 14
The AngioVac System allows for the continuous aspiration of embolic material
such as thrombi and emboli from the venous system while simultaneously reinfusing the patient's own filtered blood to limit procedural blood loss. MULTIPLE TIP ANGLES 200, 850, 1800 Proprietary Funnel Design Allows for Significant Clot
Removal Radiopaque Markers Better Tip Visibility Large-BORE Aspiration 42FR & 30FR Opening The AlphaVac System allows for the controlled aspiration of embolic material such as thrombi and emboli from the venous system. Thrombus
Management All-purpose technology platforms targeted at peripheral and cardiovascular thrombolytic events, including small and large vessels 15
AngioVac Technology The only system that enables continuous aspiration and
simultaneous reinfusion of blood, empowering physicians to treat more complex cases using minimally invasive techniques Aspiration & Simultaneous Reinfusion Proprietary Funnel On-circuit aspiration provides surgical results via
percutaneous access by simultaneously reinfusing blood back in the patient's body, minimizing blood loss. Funnel tip design enables efficient clot aspiration and compression 18Fr (33Fr) & 22Fr (42Fr) options More than 100 publications
on the use of the AngioVac system24 Use of the device has been published for caval thrombi, cardiac masses and thrombi25 16
Actual procedure results, these images represent the experience of one
institution and are not indicative of all procedural results. Clot Removal 30 min. Dr. Keeling is a paid consultant of AngioDynamics EMORY HOSPITAL - MIDTOWNDr. Brent Keeling (CT) 17
AlphaVac Technology Handle & Control Features MALE AND FEMALE CONNECTION
Ensures correct connection SYRINGE BARREL VOLUME LIMITING SWITCH Intuitive location | Multiple glove sizes DURABLE LABELS Visible in low light environments VACUUM LOCK Controlled, single-hand design ANGLED HILT Easy access to
vacuum lock TEXTURED GRIP Enhances grip control DIRECTIONAL LABELS Cannula | Waste Bag ANGLED EXIT Prevents large thrombus clog SPACER Allows sterile blood path and confirms plunger passes shelf-life constraints ROBUST
DESIGN Enables smooth pulls with contemporary design 18
Advanced - Large Bore Aspiration CANNULA Proprietary FUNNEL Manual Aspiration
HANDLE Complete SYSTEM IU HEALTHDr. Thomas Casciani (IR) & Dr. Sabah Butty* (IR) *Dr. Butty is a paid consultant of AngioDynamics Actual procedure results, these images represent the experience of one institution and are not
indicative of all procedural results. 19 Only the AlphaVac F1885 System is indicated for the treatment of pulmonary embolism (PE) . The AlphaVac F2220 and F22180 Systems are not indicated for the treatment of PE.
Pulmonary Embolism Indication Study Approval March 2022 Enrolling October
2022 Enrollment Complete December 2023 Study Complete January 2024 CE Mark Approval May 2024 FDA Clearance AlphaVac F1885 for PE April 2024 Publication of APEX-AV Trial Results in JSCAI January 2025 20 Only the AlphaVac F1885
System is indicated for the treatment of pulmonary embolism (PE) . The AlphaVac F2220 and F22180 Systems are not indicated for the treatment of PE.
APEX - AV Pivotal Study 21 Number of Sites 25 US Sites Number of
Patients 122 Timeline Oct. 2022 - Dec 2023 APEX (AlphaVac) FLARE (FlowTriever ) EXTRACT-PE28 (Indigo) Reduction in Clot Burden 35.5% 9.3% 11.3% AlphaVac F1885 received FDA clearance for PE following APEX-AV study demonstrating
efficacy and significantly improved reduction in clot burden vs. competitive technologies Significant reduction in the RV/LV ratio26 Significant improvement in the RV function 0% mortality rate29 Significant reduction in clot
burden26 Large funnel size (33 Fr) may aid in reducing the clot burden Procedure efficiency 37.2 min mean procedure time29 Atraumatic tip provides easy and efficient navigation in the Pas Ability to minimize blood loss30 21 Only the
AlphaVac F1885 System is indicated for the treatment of pulmonary embolism (PE) . The AlphaVac F2220 and F22180 Systems are not indicated for the treatment of PE.
AngioDynamics Summary Our Med Tech segment operates in key markets with unique
technologies that deliver proven clinical outcomes We have a strong track record in portfolio management, R&D, clinical and regulatory expansion, and customer-centric sales & marketing Our Med Device segment funds investments
driving Med Tech growth We maintain a debt-free, strong balance sheet We expect to be Adj. EBITDA positive by FY2025 and cash flow positive by FY2026 Our company is positioned for sustainable revenue growth and profit for years to
Shaping the Future of Cardiovascular Care: Innovative Technologies. Improved
Outcomes. INVESTOR EVENT
References FULL RISK INFO:
https://www.angiodynamics.com/about-us/risk-information Management estimates & industry
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