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Alps Group Inc Announces Potential Pipeline Expansion Beyond CELESOME(+) Following Publication of Nebulized Human Umbilical Cord Mesenchymal Stem Cell Exosome Therapy

Key Takeaway: Alps Group Inc has announced an expansion of its exosome-related pipeline following preliminary findings on nebulized human umbilical cord mesenchymal stem cell-derived exosomes. The results, published in SAGE Open Medical Case Reports, indicate potential therapeutic benefits for patients with asthma and chronic obstructive pulmonary disease (COPD). Despite promising preliminary observational results, the company acknowledges the necessity of larger-scale controlled studies to validate the effectiveness and establish standardized treatment protocols. This development may indicate a shift from standard symptom management to disease-modifying therapy.

Market Sentiment Analysis

POSITIVE FACTORS

  • Potential pipeline expansion beyond the CELESOME(+) programme.
  • Reported improvements in pulmonary function and stability in inflammatory markers.
  • Absence of significant adverse effects in preliminary case series.

CONCERNS & RISKS

  • Larger-scale, controlled studies are necessary to confirm the results.
  • No guarantee of successful completion of clinical development or obtaining health approvals.

Full Press Release Details

Group Inc Announces Potential Pipeline Expansion Beyond CELESOME(+) Following Publication of Nebulized Human Umbilical Cord Mesenchymal
Stem Cell Exosome Therapy
LUMPUR, Malaysia, January 30, 2026 - Alps Group Inc (the "Company" or "Alps Group"), the
parent company of Alps Life Sciences Inc. ("Alps Holdco"), a fully integrated biotechnology research and healthcare
platform specializing in predictive, preventive, and precision medicine, today announced a potential expansion of its exosome-related
pipeline beyond its previously disclosed CELESOME(+) programme. The announcement follows the publication of a preliminary retrospective
clinical case series in SAGE Open Medical Case Reports describing nebulized human umbilical cord mesenchymal stem cell ("hUCMSC")
derived exosome in patient with asthma and/or chronic obstructive pulmonary disease ("COPD") . The clinical case series
study was registered with the National Medical Research Register, Ministry of Health Malaysia (NMRR ID-25-00600-F4A).
Company has previously disclosed development activities relating to exosome-infused candidates under the CELESOME(+) programme. Building
on technical experience developed in connection with exosome isolation, handling, and characterisation activities described under CELESOME(+),
the published report describes observational findings from an investigational, retrospective case series involving nebulized administration
and COPD represent substantial global disease burdens, affecting approximately 260 million (BMJ Open Respiratory Research, Volume 12,
Issue 1, 2025) and 400 million (Montes de Oca et al., 2025) individuals worldwide, respectively. Current standard therapies largely focus
on symptom management. The Company believes that the reported observations may create an opportunity for nebulized human umbilical cord
mesenchymal stem cell-derived exosomes to provide targeted, potentially disease-modifying therapy for the lungs.
Tham Seng Kong, Chief Executive Officer of Alps Group, stated
retrospective case series reports preliminary clinical observations relating to nebulized hUCMSC-derived exosomes in patients with asthma
and/or COPD. The reports suggest improvements in pulmonary function, stability in inflammatory markers, and the absence of significant
adverse effects. While these findings are promising, larger-scale, controlled studies are necessary to confirm these results and establish
standardized treatment protocols."
described in the publication, each treatment dose consisted of 1 ml of exosome solution, containing a defined range of exosome particle
numbers, mixed with 5 ml of saline. The solution was administered via inhalation using a medical-grade electronic nebulizer for 30 minutes
once weekly for 5 weeks.
release discusses investigational uses of an agent in development and is not intended to convey conclusions about efficacy or safety.
There is no guarantee that any investigational uses of such product will successfully complete clinical development or obtain health
of the study and its findings have been peer-reviewed and published in SAGE Open Medical Case Reports, accessible at: https://journals.sagepub.com/doi/10.1177/2050313X251386547.
Group Inc is the parent company of Alps Life Sciences Inc., an integrated biotechnology platform integrating research and development,
medical services, and wellness solutions of advanced therapies under one unified ecosystem aimed at improving healthcare outcomes globally.
Alps Group's mission is to create a fair healthcare ecosystem, to make advance predictive, preventive, and precision medicine accessible
statements in this press release may be considered to contain certain "forward-looking statements" within the meaning of
"safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified
by words such as: "target," "believe," "expect," "will," "shall," "may,"
"anticipate," "estimate," "would," "positioned," "future," "forecast,"
"intend," "plan," "project" and other similar expressions that predict or indicate future events
or trends or that are not statements of historical matters. Forward-looking statements are neither historical facts nor assurances of
future performance. Instead, they are based only on the Company management's current beliefs, expectations, and assumptions. Because
forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that
are difficult to predict and many of which are outside of our control. Actual results and outcomes may differ materially from those indicated
in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements.
further list and description of risks and uncertainties can be found in documents filed with the Securities and Exchange Commission ("SEC")
by the Company and other documents that we may file or furnish with the SEC, which you are encouraged to read. Any forward-looking statement
made by us in this press release is based only on information currently available to the Company and speaks only as of the date on which
it is made. The Company undertakes no obligation to publicly update any forward-looking statement, whether written or oral, that may
be made from time to time, whether as a result of new information, future developments, or otherwise, except as required by law.

Frequently Asked Questions

What is the focus of Alps Group Inc's pipeline expansion?

Alps Group Inc is expanding its exosome-related pipeline beyond the CELESOME(+) program.

What diseases are targeted by nebulized hUCMSC-derived exosomes?

The therapy aims to treat asthma and chronic obstructive pulmonary disease (COPD).

What were the initial findings from the clinical case series?

The study suggested improvements in pulmonary function and stability in inflammatory markers.

How was the treatment administered in the clinical study?

The treatment involved nebulized exosome solution administered once weekly for 5 weeks.

What is the next step for the findings reported by Alps Group?

Larger, controlled studies are needed to confirm results and standardize treatment protocols.

Last updated: Jan 30, 2026