Recent Updates
Recently added Catalysts
ALNY Positive Sentiment

Alnylam Collaborator Regeneron Advances CIDEBsiRNA with Promising First-in-Human Results in Patients with MASLD

Key Takeaway: Alnylam Pharmaceuticals announced that Regeneron Pharmaceuticals reported initial results from a first-in-human trial of CIDEBsiRNA. The trial demonstrated that a single subcutaneous dose of CIDEBsiRNA effectively normalized liver fat and improved liver injury markers in patients with metabolic-dysfunction-associated steatotic liver disease (MASLD). These findings suggest significant therapeutic potential for CIDEBsiRNA.

Market Sentiment Analysis

POSITIVE FACTORS

  • CIDEBsiRNA normalized liver fat levels.
  • Improved liver injury markers in patients.
  • First-in-human trial shows promising results.

Full Press Release Details

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, today announced that its collaborator, Regeneron Pharmaceuticals, Inc. shared initial results from a first-in-human trial that demonstrated a single subcutaneous dose of CIDEBsiRNA (previously known as ALN-CIDEB) rapidly normalized liver fat and improved liver injury markers in patients with metabolic-dysfunction-associated steatotic liver disease (MASLD) with effects that wer

Frequently Asked Questions

What is CIDEBsiRNA?

CIDEBsiRNA is a therapeutic targeting liver fat in MASLD patients.

What were the results of the trial?

The trial showed normalization of liver fat and improved injury markers.

Who conducted the trial?

The trial was conducted by Regeneron Pharmaceuticals.

What condition does CIDEBsiRNA target?

CIDEBsiRNA targets metabolic-dysfunction-associated steatotic liver disease.

Last updated: Nov 10, 2026