Akari Therapeutics Announces New Data Showing A Significant Role for Complement Activation in the Clinical Outcomes of U.S. Army Trauma Patients in Iraq and the Therapeutic Potential of Nomacopan for Treatment of Trauma

Akari Therapeutics Announces New Data Showing

A Significant Role for Complement Activation in the Clinical Outcomes of U.S. Army Trauma Patients in Iraq and the Therapeutic Potential

of Nomacopan for Treatment of Trauma

NEW YORK and LONDON, February 28, 2022 - Akari Therapeutics,

Plc (Nasdaq: AKTX), a late-stage biopharmaceutical company focused on innovative therapeutics to treat orphan autoimmune and inflammatory

diseases where complement (C5) and/or leukotriene (LTB4) systems are implicated, today announced new data showing that clinical outcomes

in U.S. Army trauma patients correlate with complement activation, and that nomacopan significantly improves survival from 30% to 80%

in a clinically relevant preclinical model of traumatic hemorrhage. A full data set is available at https://doi.org/10.22541/au.164423459.98723938/v1.

Clive Richardson, Chief Executive Officer of Akari Therapeutics, commented:

"This very exciting data generated from our collaboration with the U.S. Army supports the development of nomacopan as an organ protective

drug for treatment of severe trauma patients that has the potential to significantly reduce mortality in both a military and civilian

setting. There is now a planned pathway to the clinic, and we look forward to leveraging nomacopan's dual inhibition of the pro-inflammatory

complement C5 and leukotriene LTB4 as a potential treatment for traumatic injury."

Traumatic hemorrhage (TH) is the leading cause of potentially preventable

deaths that occur during the pre-hospital phase of care. Current treatments still largely rely on organ/tissue supportive approaches and

fluid resuscitation, and no effective pharmacological therapeutics are available. Identifying new life- supporting treatment focused on

the interval between point of injury to hospital is a key objective. Military blast injury accounted for 70%-80% of U.S. casualties in

Iraq and Afghanistan, while in the U.S. there are approximately 500,000 civilian trauma hospital discharges a year which are defined as

severe and could benefit from early drug intervention to reduce multi-organ dysfunction. Annual inpatient trauma-related hospital costs

in the U.S. are approximately $30 billion a year1.

An analysis of 54 military trauma patients in Baghdad with blast and

gunshot injury showed that three key markers of complement activation - C5a, C5b9 and Bb - were elevated 300%-600% in the

first eight hours after the traumatic event, compared to healthy controls. In addition, pro-inflammatory C5a and C5b9 plasma levels correlated

with trauma severity, and complement activation correlated with clinical outcomes.

Nomacopan's mode of action may be particularly suited for treatment

of TH as critically it inhibits terminal complement activation (C5a, C5b9) via all three complement pathways (classical, lectin and alternative)

and additionally inhibits leukotriene B4 (LTB4) which is also implicated in exacerbation of TH.

To test the anticipated efficacy of nomacopan, a clinically relevant

pre-clinical model of blast injury and hemorrhagic shock was undertaken by the United States Army Institute of Surgical Research (USAISR).

The addition of nomacopan to damage control resuscitation protocol, significantly inhibited terminal complement activity, decreased local

and systemic inflammatory responses, improved hemodynamics and metabolism, attenuated tissue and organ damage and increased survival (80%

Nomacopan's therapeutic efficacy in this model of TH is likely

a result of the drugs inhibition of multiple inflammatory pathways primarily:

Nomacopan is particularly well suited for pre-hospital use in both

a battlefield/military or ambulance/ civilian setting due to the molecules thermostability and ease of administration. In addition, nomacopan

is fast acting and clears the body within a matter of days is also important in that the optimal window for treatment by inhibiting complement

is likely to be the first 24 hours following TH.

The planned next steps include an extension study following on from

the reported USAISR program. Also, in parallel, a collaboration for a UK observational study with civilian traumatic brain injury patients

to optimize the nomacopan clinical treatment regimen leading to a potential clinical study that could include both military and civilian

1 Source: (DiMaggio et al., 2016, Traumatic injury in the

About Akari Therapeutics

Akari is a biopharmaceutical company focused

on developing inhibitors of acute and chronic inflammation, specifically for the treatment of rare and orphan diseases, in particular

those where the complement (C5) or leukotriene (LTB4) systems, or both complement and leukotrienes together, play a primary role in disease

progression. Akari's lead drug candidate, Nomacopan (formerly known as Coversin), is a C5 complement inhibitor that also independently

and specifically inhibits leukotriene B4 (LTB4) activity. Nomacopan is currently being clinically evaluated in four areas: bullous pemphigoid

(BP), thrombotic microangiopathy (TMA), as well as programs in the eye and lung.

Cautionary Note Regarding

Forward-Looking Statements

Certain statements in this press release constitute "forward-looking

statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements reflect

our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available

to us and on assumptions we have made. Although we believe that our plans, intentions, expectations, strategies and prospects as reflected

in or suggested by those forward-looking statements are reasonable, we can give no assurance that the plans, intentions, expectations

or strategies will be attained or achieved. Furthermore, actual results may differ materially from those described in the forward-looking

statements and will be affected by a variety of risks and factors that are beyond our control. Such risks and uncertainties for our company

include, but are not limited to: needs for additional capital to fund our operations, our ability to continue as a going concern; uncertainties

of cash flows and inability to meet working capital needs; an inability or delay in obtaining required regulatory approvals for Nomacopan

and any other product candidates, which may result in unexpected cost expenditures; our ability to obtain orphan drug designation in additional

indications; risks inherent in drug development in general; uncertainties in obtaining successful clinical results for Nomacopan and any

other product candidates and unexpected costs that may result therefrom; difficulties enrolling patients in our clinical trials; our ability

to enter into collaborative, licensing, and other commercial relationships and on terms commercially reasonable to us; failure to realize

any value of Nomacopan and any other product candidates developed and being developed in light of inherent risks and difficulties involved

in successfully bringing product candidates to market; inability to develop new product candidates and support existing product candidates;

the approval by the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) and any other similar foreign regulatory

authorities of other competing or superior products brought to market; risks resulting from unforeseen side effects; risk that the market

for Nomacopan may not be as large as expected; risks associated with the impact of the COVID-19 pandemic; inability to obtain, maintain

and enforce patents and other intellectual property rights or the unexpected costs associated with such enforcement or litigation; inability

to obtain and maintain commercial manufacturing arrangements with third party manufacturers or establish commercial scale manufacturing

capabilities; the inability to timely source adequate supply of our active pharmaceutical ingredients from third party manufacturers on

whom the company depends; unexpected cost increases and pricing pressures and risks and other risk factors detailed in our public filings

with the Securities and Exchange Commission (SEC), including our most recently filed Annual Report on Form 20-F filed with the SEC. Except

as otherwise noted, these forward-looking statements speak only as of the date of this press release and we undertake no obligation to

update or revise any of these statements to reflect events or circumstances occurring after this press release. We caution investors not

to place considerable reliance on the forward-looking statements contained in this press release.

For more information

Sukaina Virji/ Maya Bennison

Consilium Strategic Communications