Company/Investor Contact: Charles Jones CJones & Associates Public Relations 888-557-6480 305-987-7418 cjones@cjonespr.com Hemispherx Biopharma Announces Corporate Progress and Financial Results for the Six Months Ended

& Associates Public Relations

Biopharma Announces Corporate Progress and Financial Results for the

Six Months Ended June 30, 2017

Company has Generated Revenues and Advanced in R&D for Intranasal Ampligen and in Immuno-Oncology

Call Scheduled for Tuesday, August 15th at 1:00 PM EDT

- August 15, 2017 - Hemispherx Biopharma (NYSE MKT: HEB): This quarter we see Ampligen potentially repurposed

beyond the single indication of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), to maximize the potential of this

proven immunotherapeutic in indications in which a healthier and more stimulated immune system can play an important role in successful

outcomes. We have made Ampligen available in an Early Access Program for pancreatic cancer patients, looking at quality of

life measures and collecting immunological data which we hope will help direct research into combinational therapies for this

and other lethal solid tumors. We also see future opportunities for Ampligen as a potential immune-enhancing vaccine adjuvant.

As we recently announced, we believe that the intranasal human safety study of Ampligen plus FluMist known as AMP-600

indicates that intranasal Ampligen is generally well-tolerated. Finally, this quarter we have made significant steps toward

a potential New Drug Application in Canada for ME/CFS by working with patient advocacy groups and doctors, led by Millions Missing

announced its financial results for the six months ended June 30, 2017. The net loss was approximately $5,014,000 or ($0.19) per

share as compared to a net loss of $3,467,000 or ($0.16) per share for the same six month period in 2016. Cash, cash equivalents

and marketable securities were approximately $3,211,000 at June 30, 2017 as compared to $5,868,000 as of December 31, 2016.

from our Ampligen Cost Recovery Program were $213,000 and $15,000 for the three months ended June 30, 2017 and 2016, respectively,

primarily due to our Early Access Program, through our agreement with MyTomorrows, designed to enable access of Ampligen

to pancreatic cancer patients in the Netherlands. The increase in revenues of $198,000 is an increase of 1,320%. Revenues from

our Ampligen Cost Recovery Program were $297,000 and $54,000 for the six months ended June 30, 2017 and 2016, respectively.

The increase in revenues of $243,000 is an increase of 450%.

intend to continue our pursuit of profitable self-sufficiency while seeking FDA approval of Ampligen in the United States

and rapid expansion of our European operations.

Hemispherx Biopharma

Biopharma, Inc. is an advanced specialty pharmaceutical company engaged in the clinical development of new drug entities for treatment

of seriously debilitating disorders. Hemispherx's flagship products include Alferon N Injection and the experimental

therapeutic rintatolimod (tradenames Ampligen or Rintamod ). Rintatolimod is an experimental RNA nucleic acid being developed

for globally important debilitating diseases and disorders of the immune system, including Myalgic Encephalomyelitis/Chronic Fatigue

Syndrome (ME/CFS). Hemispherx's platform technology includes components for potential treatment of various severely debilitating

and life threatening diseases. Because rintatolimod is experimental in nature, it is not designated safe and effective by the

FDA for general use and is legally available only through clinical trials.

of the statements included in this press release may be forward-looking statements that involve a number of risks and uncertainties.

For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities

Litigation Reform Act of 1995. In addition to the risk factors identified from time to time in our reports filed with the Securities

and Exchange Commission, no assurance can be given that Ampligen will prove effective in the treatment of pancreatic cancer

or any other additional indications or that additional testing will confirm that it is effective when administered intranasally.

Moreover, conducting such studies will require Hemispherx to obtain additional financing and no assurance can be given that such

funding will be available. While Hemispherx had begun to generate revenues from Ampligen , no assurance can be given that

revenues will continue or grow. Any forward-looking statements set forth in this press release speak only as of the date of this

press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur

after the date hereof. This press release and prior releases are available at www.hemispherx.net. The information found

on our website is not incorporated by reference into this press release and is included for reference purposes only.