Full Press Release Details
ImmunoTech and Shenzhen Smoore Technology Announce an Agreement to Research Utilizing an Innovative Smoore Inhalation Delivery
Device and Ampligen (rintatolimod) as a Potential, Easy-To-Use Treatment Approach for the SARS-CoV-2 Pandemic
Fla. - April 6, 2020 - AIM ImmunoTech (NYSE American: AIM) today announced it has entered into a Material
Transfer and Research Agreement (MTA) with Shenzhen Smoore Technology Limited. According to a market survey report by Frost &
Sullivan, Smoore is the world's largest vaping device manufacturer in terms of revenue in 2019, whose products include but
are not limited to high-tech inhalation devices. The purpose of the MTA is to research in China the efficacy of Smoore's
inhalation delivery device using Ampligen, AIM's flagship drug, which has been approved for ME/CFS in Argentina and experimental
through phase 3 clinical trials in the U.S. AIM believes Ampligen has potential as a prophylactic/early-onset therapeutic against
COVID-19, the disease caused by SARS-CoV-2.
pluripotent Toll Like Receptor 3 (TLR3) agonist, Ampligen, has yielded pre-clinical 100% protective efficacy against SARS-CoV-1
viral infection in duplicate experiments using a mouse model in U.S. National Institutes of Health-contracted animal testing (see:
Day 2009 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787736/] and Barnard 2006 [https://journals.sagepub.com/doi/abs/10.1177/095632020601700505])
and AIM has human safety data (see: Overton 2014 [https://www.sciencedirect.com/science/article/pii/S0264410X14010457?via%3Dihub])
showing Ampligen to be generally well tolerated when administered intranasally to humans in addition to the extensive safety data
from approximately 100,000 IV doses in humans.
this leads to the strong hypothesis, which AIM and Smoore jointly seek to prove through this experimental program. We believe
that Ampligen, when administered deep into the lungs at the first signs of the disease via the Smoore device - designed
to carefully distribute different-sized particles of Ampligen - may initiate a therapeutic TLR3 response throughout the
upper and lower respiratory system that will stop the SARS-CoV-2 virus in its tracks," states AIM CEO Thomas K. Equels.
"Smoore is without question one of the world's leading innovators of vaporization technology. We are excited and eager
to test Ampligen using Smoore's advanced inhalation device. If we can make the administration of Ampligen as easy as vaping
and delivering nicotine, and testing proves Ampligen has COVID-19 efficacy as a prophylaxis, then this combination has the potential
to be a powerful and easily self-administered tool in the global effort to stop the COVID-19 pandemic."
the world's largest vaping device manufacturer in terms of revenue in 2019 and global leader in offering vaping technology
solutions with advanced R&D technology, we are excited to have this opportunity to work with AIM in exploring the medical
inhalation of Ampligen in the combat of COVID-19 pandemic. We believe conventional medical inhalation devices can be miniaturized
and mass produced with better dosage and aerosol particle size control with our proprietary technology. Given the pre-clinical
protective efficacy against SARS-CoV-1 viral infection and human safety data established by our partner, with proper vaporization
of Ampligen via an easy-to-use device, we see a potential to help more people in the world in combating the current COVID-19 pandemic,
and this collaboration represents an important first step." Commented by Dr. Zhiqiang Shi, Chief Science Officer of Smoore.
Chief Science Officer David Strayer, MD, adds: "The clear goal of this research is to develop a self-administered inhalation
device capable of safely delivering an Ampligen atomized mist deep into the pulmonary airways. We believe this approach may have
potential as a prophylactic/early-onset therapeutic for COVID-19."
ImmunoTech Inc. is an immuno-pharma company focused on the research and development of therapeutics to treat immune disorders,
viral diseases and multiple types of cancers. AIM's flagship products include the Argentina-approved drug rintatolimod (trade
names Ampligen or Rintamod ) and the FDA-approved drug Alferon N Injection . Based on results of published, peer-reviewed
pre-clinical studies and clinical trials, AIM believes that Ampligen may have broad-spectrum anti-viral and anti-cancer properties.
Clinical trials of Ampligen include studies of cancer patients with renal cell carcinoma, malignant melanoma, colorectal
cancer, advanced recurrent ovarian cancer and triple negative metastatic breast cancer. These and other potential uses will require
additional clinical trials to confirm the safety and effectiveness data necessary to support regulatory approval and additional
funding. Rintatolimod is a double-stranded RNA being developed for globally important debilitating diseases and disorders of the
press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.
Words such as "may," "will," "expect," "plan," "anticipate" and similar
expressions (as well as other words or expressions referencing future events or circumstances) are intended to identify forward-looking
statements. These statements involve a number of risks and uncertainties. For example, significant additional testing and trials
will be required to determine whether Ampligen will be effective in the treatment of COVID-19 in humans and no assurance can be
given that it will be the case. Results obtained in animal models do not necessarily predict results in humans. Human clinical
trials will be necessary to prove whether or not Ampligen will be efficacious in humans. Some of the world's largest pharmaceutical
companies and medical institutions are racing to find a treatment for COVID-19. Even if Ampligen proves effective in combating
the virus, no assurance can be given that our actions toward proving this will be given first priority or that another treatment
that eventually proves capable will not make our efforts ultimately unproductive. Assuming Ampligen timely proves effective, significant
testing will be required to determine if the Smoore device will be able to safely deliver Ampligen in an appropriate dose without
diminishing its efficacy against COVID-19. No assurance can be given that future studies will not result in findings that are
different from those reported in the studies referenced herein. Operating in foreign countries carries with it a number of risks,
including potential difficulties in enforcing intellectual property rights. We cannot assure that our potential foreign operations
will not be adversely affected by these risks. With regard to the Company's activities with Ampligen generally, no assurance
can be given as to whether current or planned trials will be successful or yield favorable data and the trials are subject to
many factors including lack of regulatory approval(s), lack of study drug, or a change in priorities at the institutions sponsoring
other trials. In addition, initiation of planned clinical trials may not occur secondary to many factors including lack of regulatory
approval(s) or lack of study drug. Even if these clinical trials are initiated, the Company cannot assure that the clinical studies
will be successful or yield any useful data or require additional funding. There also is the potential for delays in clinical
trial enrollment and reporting in ongoing studies in cancer patients because of the COVID-19 medical emergency. Any forward-looking
statements set forth herein speak only as of the date of this press release. The Company does not undertake to update any of these
forward-looking statements to reflect events or circumstances that occur after the date hereof. The information found on our website
is not incorporated by reference herein and is included for reference purposes only.