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Agenus Announces Nature Medicine Publication of Multicenter UNICORN Phase 2 Trial Demonstrating Deep Responses with Neoadjuvant BOT+BAL in Resectable Colon Cancer

Key Takeaway: Agenus Inc. announced the publication of results from the Phase 2 UNICORN trial in Nature Medicine. The trial evaluated the neoadjuvant use of botensilimab and balstilimab in patients with resectable colon cancer. Results indicated deep responses, showcasing the potential of this combination therapy.

Market Sentiment Analysis

POSITIVE FACTORS

  • Publication in a peer-reviewed journal
  • Demonstrated deep responses in colon cancer
  • Successful results from a multicenter trial
  • Combination therapy shows promise

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+203%
120-day peak, hindsight
Typical move
5.5%
average across 3 past catalysts
Cash runway
~0 mo
High dilution risk
Lead asset
Balstilimab
Phase 3 · Colorectal Cancer

Full Press Release Details

LEXINGTON, Mass.--(BUSINESS WIRE)---- $AGEN #AGEN--Agenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology innovation, today announced the peer-reviewed publication of results from the investigator-sponsored, multicenter Phase 2 UNICORN trial evaluating short-course preoperative, or neoadjuvant, botensilimab (BOT), Agenus’ multifunctional, Fc-enhanced anti-CTLA-4 antibody, alone or in combination with balstilimab (BAL), Agenus’ anti-PD-1 antibody, in patients with resectable, locally advanced colon cancer. The

Frequently Asked Questions

What is the UNICORN trial?

The UNICORN trial is a Phase 2 study evaluating botensilimab and balstilimab in colon cancer.

What were the results of the UNICORN trial?

The trial demonstrated deep responses in patients with resectable colon cancer.

What is botensilimab?

Botensilimab is an Fc-enhanced anti-CTLA-4 antibody developed by Agenus.

What is balstilimab?

Balstilimab is an anti-PD-1 antibody also developed by Agenus.

Last updated: Nov 2, 2026