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Image of Ebola viruses exiting host cells - Courtesy of NIAID 1
The following presentation may contain predictions, estimates, and other forward looking statements that involve risks and uncertainties, including whether and when our products are successfully developed and introduced ; market acceptance of the Aethlon Hemopurifier and other product offerings ; regulatory delays, manufacturing delays, and other risks detailed in our SEC filings, which are accessible at www . sec . gov or on our website : www . AethlonMedical . com
TO ADDRESS U NMET NEEDS IN GLOBAL HEALTH & BIODEFENSE FOCUS
FDA EXPEDITED ACCESS PATHWAY PROGRAM SUBMISSION 6
THE UNITED STATES FOOD AND DRUG ADMINISTRATION (FDA) HAS DESIGNATED THE AETHLON HEMOPURIFIER TO THE EXPEDITED ACCESS PATHWAY (EAP) PROGRAM RELATED TO THE TREATMENT OF LIFE - THREATENING VIRUSES THAT ARE NOT ADDRESSED WITH AN APPROVED THERAPY
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9 A SIGNIFICANT UNMET NEED IN GLOBAL HEALTH & BIODEFENSE
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GOAL OF OUR EAP PROGRAM SUBMISSION
HEMOPURIFIER CAPTURE VALIDATIONS OF HIGHLY GLYCOSYLATED VIRUSES
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d , dZ dD Ed K& K s/Zh^ A SINGLE 6 . 5 - HOUR ADMINISTRATION OF H EMOPURIFIER THERAPY WAS DELIVERED TO THE PATIENT , WHO WAS COMATOSE WITH MULTIPLE ORGAN FAILURE .
THE TREATMENT OF EBOLA VIRUS
VIRUS CAPTURE ASSAY RESULT
Extracorporeal Virus Elimination for the Treatment of Severe Ebola Virus Disease - First Experience with Lectin Affinity Plasmapheresis B ttner S. a Koch B. a Dolnik O. b Eickmann M. b Freiwald T. a Rudolf S. a Engel J. a Becker S. b Ronco C. c Geiger H. a Author affiliations Corresponding Author Keywords: Ebola virusGlycoproteinLectin affinityPlasmapheresis February 2015 Abstract Therapeutic options for Ebola virus disease (EVD) are currently limited to ( 1 ) best supportive care, and ( 2 ) evolving virus - specific therapies, resulting from decades of analyzing one of the world's deadliest diseases . Supportive care ranges from oral or intravenous rehydration therapy and anti - emetics in developing countries to much more extensive life - support interventions in resource - rich countries . Current EVD - specific therapies attempt to either interfere with the earliest steps of viral replication or to elicit a strong immune response against the virus . An entirely new approach is the extracorporeal elimination of viruses and viral glycoproteins by lectin affinity plasmapheresis . Herein, we report for the first time the successful and safe use of lectin affinity plasmapheresis in a patient with severe Ebola virus disease .
A SIGNIFICANT UNMET NEED IN GLOBAL HEALTH & BIODEFENSE
THE AETHLON HEMOPURIFIER ALIGNS TO MEET 5 DIFFERENT PHEMCE OBJECTIVES
LEVERAGE EAP PATHWAY DESIGNATION TO ESTABLISH COMMERCIALIZATION PATHWAY FOR VIRUSES THAT ARE ; LIFE - THREATENING HIGHLY - GLYCOSYLATED NOT ADDRESSED WITH AN APPROVED THERAPY AND , HAVE BEEN VALIDATED TO BE CAPTURED BY THE AETHLON HEMOPURIFIER
Focused on diagnosing diseases that are current or future therapeutic targets for Aethlon Medical