Adaptimmune Announces Completion of Strategic Combination with TCR² Therapeutics Creating a Preeminent Solid Tumor Cell Therapy Company First marketed engineered T-cell therapy for a solid tumor; BLA for afami-cel o

Adaptimmune Announces

Completion of Strategic Combination with TCR² Therapeutics Creating a Preeminent Solid Tumor Cell Therapy Company

First marketed engineered

T-cell therapy for a solid tumor; BLA for afami-cel on track to complete submission in mid-2023

data with late-stage programs targeting MAGE-A4 and mesothelin

Preclinical programs

targeting PRAME and CD70 in IND-enabling studies

into early 2026 with multiple value creating catalysts

tomorrow, June 2nd at 8 a.m. EDT: https://www.gowebcasting.com/12589

OXFORD, UK, June 1, 2023 - Adaptimmune Therapeutics plc (Nasdaq: ADAP) today announced completion of an all-stock transaction

in which Adaptimmune has combined with TCR² Therapeutics Inc. (Nasdaq: TCRR) to create a preeminent T-cell therapy company to treat

lead clinical franchises utilize engineered T-cell therapies targeting MAGE-A4 and mesothelin, which are expressed on a broad range of

solid tumors. Use of these cell therapies is supported by compelling clinical data including results in late-stage synovial sarcoma which

will form the basis of the Company's first BLA submission to complete in mid-2023. The Company has access to an enhanced "next-gen

toolbox" and an extended preclinical pipeline with development initially focused on PRAME and CD70.

Adaptimmune's Chief Executive Officer: "We are delighted to welcome our new colleagues to Adaptimmune. Together, we will

advance our industry leading pipeline making cell therapy a mainstream option for people with cancer. This starts with gaining approval

for the first engineered T-cell therapy for a solid tumor - afami-cel for the treatment of synovial sarcoma - and progressing our Phase

2 trials for patients with ovarian cancer with both ADP-A2M4CD8 and gavo-cel."

Solid Tumor Opportunity

Clinical development

decisions driven by data catalysts

of strategic combination

strategic combination was consummated on June 1, 2023. Adaptimmune shareholders own approximately 75% of the combined company and

prior TCR2 stockholders own approximately 25% of the combined company.

combined company will continue to trade on the Nasdaq Stock Market under the symbol "[ADAP]". The combined company comprises

a team of leading cell therapy experts led by Adrian Rawcliffe, the CEO of Adaptimmune. The Board of Directors is composed of three members

from TCR2 and six continuing from Adaptimmune: David Mott (Chair); Andrew

Allen, MD, PhD; Lawrence Alleva; Ali Behbahani, MD; John Furey; Priti

Hegde, PhD, Kristen Hege, MD (as of November 1, 2023), Garry Menzel,

PhD, Adrian Rawcliffe, Elliot Sigal, MD, PhD.

and Company LLC is serving as financial advisor to Adaptimmune and Ropes & Gray LLP is serving as legal counsel to Adaptimmune.

Piper Sandler is serving as financial advisor to TCR2 and Goodwin Procter LLP is serving as legal counsel to TCR2.

includes express or implied forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended,

and Section 21E of the Securities Exchange Act of 1934, as amended (the "Exchange Act"). Actual events or results may

differ materially from these forward-looking statements. Words such as "will," "could," "would,"

"should," "expect," "plan," "anticipate," "intend," "believe,"

"estimate," "predict," "project," "potential," "continue," "future,"

"opportunity" "will likely result," "target," variations of such words, and similar expressions or

negatives of these words are intended to identify such forward-looking statements, although not all forward-looking statements contain

these identifying words. Examples of such forward-looking statements include, but are not limited to, express or implied statements regarding:

the business combination and related matters, including, but not limited to, prospective performance and opportunities with respect to

Adaptimmune or TCR2, post-closing operations and the outlook for the companies' businesses; Adaptimmune's, TCR2's

or the combined company's targets, plans, objectives or goals for future operations, including those related to Adaptimmune's

and TCR2's product candidates, research and development, product candidate introductions and product candidate approvals

as well as cooperation in relation thereto; projections of or targets for revenues, costs, income (or loss), earnings per share, capital

expenditures, dividends, capital structure, net financials and other financial measures; future economic performance, future actions

and outcomes of contingencies such as legal proceedings; and the assumptions underlying or relating to such statements.

are based on Adaptimmune's and TCR2's current plans, estimates and projections. By their very nature, forward-looking

statements involve inherent risks and uncertainties, both general and specific. A number of important factors, including those described

in this communication, could cause actual results to differ materially from those contemplated in any forward-looking statements. Factors

that may affect future results and may cause these forward-looking statements to be inaccurate include, without limitation: the risk

that Adaptimmune and TCR2 may not realize the anticipated benefits of the transaction in the time frame expected, or at all;

the effects of the transaction on relationships with Adaptimmune's or TCR2's employees, business or collaboration

partners or governmental entities; the ability to retain and hire key personnel; potential adverse reactions or changes to business relationships

resulting from the completion of the transaction; significant or unexpected costs, charges or expenses resulting from the transaction;

the potential impact of unforeseen liabilities, future capital expenditures, revenues, costs, expenses, earnings, synergies, economic

performance, indebtedness, financial condition and losses on the future prospects, business and management strategies for the management,

expansion and growth of the combined business; uncertainties as to the long-term value of Adaptimmune's American Depositary Shares

(and the ordinary shares represented thereby), including the dilution caused by Adaptimmune's issuance of additional American Depositary

Shares (and the ordinary shares represented thereby) in connection with the transaction; unknown liabilities related to Adaptimmune or

TCR2; the nature, cost and outcome of any litigation and other legal proceedings involving Adaptimmune, TCR2 or their respective directors,

including any legal proceedings related to the transaction; risks related to global as well as local political and economic conditions,

including interest rate and currency exchange rate fluctuations; potential delays or failures related to research and/or development

of Adaptimmune's or TCR2's programs or product candidates; risks related to any loss of Adaptimmune's or

TCR2's patents or other intellectual property rights; any interruptions of the supply chain for raw materials or manufacturing

for Adaptimmune or TCR2's product candidates, the nature, timing, cost and possible success and therapeutic applications

of product candidates being developed by Adaptimmune, TCR2 and/or their respective collaborators or licensees; the extent

to which the results from the research and development programs conducted by Adaptimmune, TCR2, and/or their respective collaborators

or licensees may be replicated in other studies and/or lead to advancement of product candidates to clinical trials, therapeutic applications,

or regulatory approval; uncertainty of the utilization, market acceptance, and commercial success of Adaptimmune's or TCR2's

product candidates, and the impact of studies (whether conducted by Adaptimmune, TCR2 or others and whether mandated or voluntary) on

any of the foregoing; unexpected breaches or terminations with respect to Adaptimmune's or TCR2's material contracts

or arrangements; risks related to competition for Adaptimmune's or TCR2's product candidates; Adaptimmune's

or TCR2's ability to successfully develop or commercialize Adaptimmune's or TCR2's product candidates;

Adaptimmune's, TCR2's, and their collaborators' abilities to continue to conduct current and future developmental,

preclinical and clinical programs; potential exposure to legal proceedings and investigations; risks related to changes in governmental

laws and related interpretation thereof, including on reimbursement, intellectual property protection and regulatory controls on testing,

approval, manufacturing, development or commercialization of any of Adaptimmune's or TCR2's product candidates;

unexpected increase in costs and expenses with respect to the transaction or Adaptimmune's or TCR2's business

or operations; and risks and uncertainties related to epidemics, pandemics or other public health crises and their impact on Adaptimmune's

and TCR2's respective businesses, operations, supply chain, patient enrollment and retention, preclinical and clinical

trials, strategy, goals and anticipated milestones. While the foregoing list of factors presented here is considered representative,

no list should be considered to be a complete statement of all potential risks and uncertainties. A more complete description of these

and other material risks can be found in Adaptimmune's filings with the U.S. Securities and Exchange Commission (the "SEC"),

including Adaptimmune's Annual Report on Form 10-K for the year ended December 31, 2022, subsequent Quarterly Reports

on Form 10-Q and other documents that may be filed from time to time with the SEC.

statements speak only as of the date of this communication and are made based on the current beliefs and judgments of Adaptimmune's

management, and the reader is cautioned not to rely on any forward-looking statements made by Adaptimmune. Unless required by law, Adaptimmune

is under no duty and undertakes no obligation to update or revise any forward-looking statement after the distribution of this document,

including without limitation any financial projection or guidance, whether as a result of new information, future events or otherwise.

P. Miller, Ph.D. - VP, Corporate Affairs and Investor Relations

Lynch, Senior Director of Corporate Communications