Full Press Release Details
Unveils Preclinical Data from Two Transformative Antibody Programs
at Upcoming American Society of Hematology (ASH) Annual Meeting
Presentations demonstrate compelling preclinical differentiation of an anti-CD47 antibody and a CD20xCD3 bispecific T-cell engager, both
leveraging SAFEbody technology -
Both candidates designed to overcome development challenges of two promising immuno-oncology targets -
DIEGO and SUZHOU, China, November 4, 2021 - Adagene Inc. ("Adagene") (Nasdaq: ADAG), a platform-driven, clinical-stage
biopharmaceutical company committed to transforming the discovery and development of novel antibody-based immunotherapies, today announced
publication of two abstracts featuring preclinical data from its expanding pipeline in advance of the 63rd ASH Annual Meeting
preclinical results show compelling differentiation of ADG153, an anti-CD47 SAFEbody and ADG152, a CD20xCD3 POWERbody integrating
the company's proprietary bispecific T-cell engager (TCE) platform with SAFEbody masking technology. The full abstracts will be available
on the ASH Annual Meeting and Exposition website in anticipation of poster presentations at the hybrid meeting being held virtually and
in Atlanta, Georgia from December 11-14, 2021.
for the poster presentations during ASH 2021 include:
Monday, December 13, 2021
Session III: 9:00 a.m. - 8:00 p.m. ET
& Time (for in-person participants): Hall B5 from 6:00 p.m. - 8:00 p.m. ET
Saturday, December 11, 2021
Session I: 9:00 a.m. - 7:30 p.m. ET
& Time (for in-person participants): Hall B5 from 5:30 p.m. - 7:30 p.m. ET
are excited to share the first preclinical results from our ongoing evaluation of ADG152 and ADG153, which are two novel programs
emerging from our deep, broad, and differentiated pipeline," said Peter Luo, Ph.D., Co-founder, Chief Executive Officer and
Chairman of Adagene. "The known challenges of targeting CD47 - specifically, the need for a Fc dependent efficacious
antibody without triggering on-target off tumor liabilities, including binding to red blood cells or showing significant antigen
sink in healthy cells - and those of bispecific CD3 TCEs - a clinically validated, powerful modality with
cytokine release syndrome limiting their utility - are the ideal problems for our AI-powered platform and antibody engineering
teams to overcome in a tailor-made manner."
Luo continued, "We look forward to presenting more detailed results during the ASH sessions, including new data from our ADG153
program, with one of the first ever anti-CD47 antibodies of the IgG1 isotype on track for clinical development. Additionally, ADG152
is the first novel bispecific TCE that incorporates our SAFEbody anti-CD3 antibody which has a low binding affinity and demonstrates
strong anti-tumor activity while maintaining an impressive control of cytokine release in vivo, an outstanding issue facing many TCEs
in clinical development. We are extremely encouraged by the data supporting differentiation of these candidates, which collectively showcase
how we are on the forefront of antibody discovery and development to address patient needs."
preclinical findings also reflect the advantages of the company's AI-driven antibody discovery and development platform, which
integrates the dynamic properties of antibody-based therapeutics into structure and design. Specifically, by targeting novel epitopes
and introducing conditionally-activated masking technology, Adagene develops antibody candidates with tailor-made safety and efficacy
profiles. When applied to powerful antibody-based modalities such as bispecific TCEs and antibody-drug conjugates, these therapeutic
candidates are designed to reach beyond the therapeutic potency of traditional monospecific antibodies, while maintaining patient safety.
These transformative technologies are known as NEObody , SAFEbody and POWERbody .
ADG152 and ADG153 are potential Investigational New Drug candidates from Adagene's growing portfolio of preclinical discovery programs,
five of which are in IND-enabling studies.
Inc. (Nasdaq: ADAG) is a platform-driven, clinical-stage biopharmaceutical company committed to transforming the discovery and development
of novel antibody-based cancer immunotherapies. Adagene combines computational biology and artificial intelligence to design novel antibodies
that address unmet patient needs. Powered by its proprietary Dynamic Precision Library (DPL) platform, composed of NEObody , SAFEbody ,
and POWERbody technologies, Adagene's highly differentiated pipeline features novel immunotherapy programs. Adagene has
forged strategic collaborations with reputable global partners that leverage its technology in multiple approaches at the vanguard of
more information, please visit: https://investor.adagene.com.
press release contains forward-looking statements, including statements regarding ADG152 and ADG153 preclinical studies, the
potential implications of preclinical findings of ADG152 and ADG153, and Adagene's advancement of, and anticipated clinical
development, regulatory milestones and commercialization of Adagene pipeline candidates. Actual results may differ materially from
those indicated in the forward-looking statements as a result of various important factors, including but not limited to
Adagene's ability to demonstrate the safety and efficacy of its drug candidates; the clinical results for its drug candidates,
which may not support further development or regulatory approval; the content and timing of decisions made by the relevant
regulatory authorities regarding regulatory approval of Adagene's drug candidates; Adagene's ability to achieve
commercial success for its drug candidates, if approved; Adagene's ability to obtain and maintain protection of intellectual
property for its technology and drugs; Adagene's reliance on third parties to conduct drug development, manufacturing and
other services; Adagene's limited operating history and Adagene's ability to obtain additional funding for operations
and to complete the development and commercialization of its drug candidates; Adagene's ability to enter into additional
collaboration agreements beyond its existing strategic partnerships or collaborations, and the impact of the COVID-19 pandemic on
Adagene's clinical development, commercial and other operations, as well as those risks more fully discussed in the
"Risk Factors" section in Adagene's filings with the U.S. Securities and Exchange Commission. All forward-looking
statements are based on information currently available to Adagene, and Adagene undertakes no obligation to publicly update or
revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required