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STATEN ISLAND, N.Y.,Oct. 9, 2025/PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a late-stage biopharmaceutical company developing a new class of small molecule antibiotics for difficult-to-treat bacterial infections, today announced that a new patent has been granted by the Australian Patent Office. This patent relates to DNA Polymerase IIIC Inhibitors, including compositions-of- matter. This is the latest in the series of granted patents and pending patent applications that Acurx has filed to protect its proprietary technologies in the field of antimicrobials. To date, Acurx has obtained three U.S. patents, one Israeli patent, one Japanese patent, one Indian patent, and now an Australian patent, in each case, which cover the ACX-375C program, relating to DNA Polymerase IIIC Inhibitors, with other country-level filings in process.
Robert J. DeLuccia, Executive Chairman of Acurx, stated: "Achieving this patent in Australia adds to our growing number of countries where we are patent protected for a long period of time as we further develop our innovative, AI-supported drug discovery platform of second-generation DNA pol IIIC inhibitors. We believe these new compounds have potential to transform the antibiotic treatment paradigm to combat multidrug-resistant Gram-positive pathogens such asStaphylococcus aureus, including MRSA, VRE, and PRSP; furthermore, these compounds are expected to be active againstB. anthracisor anthrax, a Bioterrorism Category A Threat-Level pathogen".
He further stated: "While our lead DNA pol IIIC inhibitor is Phase 3-ready for oral treatment ofC. difficileInfection, and has validated the bacterial target for DNA pol IIIC inhibitors, our new preclinical compounds are systemically absorbed for potential oral and parenteral use in clinical settings such as acute bacterial skin and skin-structure infections (ABSSSI, including MRSA), Community-acquired bacterial pneumonia (CABP), hospital and/or ventilator-associated bacterial pneumonia (HABP/VABP); bacteremia with or w/o sepsis and/or infectious endocarditis; bone/joint infections, prosthetic joint infections and inhalational anthrax".
About Acurx Pharmaceuticals, Inc.Acurx Pharmaceuticals is a late-stage biopharmaceutical company focused on developing a new class of small molecule antibiotics for difficult-to-treat bacterial infections. The Company's approach is to develop antibiotic candidates with a Gram-positive selective spectrum (GPSS®) that blocks the active site of the Gram-positive specific bacterial enzyme DNA polymerase IIIC (pol IIIC), inhibiting DNA replication and leading to Gram-positive bacterial cell death. Its R&D pipeline includes antibiotic product candidates that target Gram- positive bacteria, including Clostridioides difficile, methicillin- resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus (VRE), drug- resistant Streptococcus pneumoniae (DRSP) and B. anthracis (anthrax; a Bioterrorism Category A Threat-Level pathogen). Acurx's lead product candidate, ibezapolstat, for the treatment of C. difficile Infection is Phase 3 ready with plans in progress to begin international clinical trials as soon as possible. The Company's preclinical pipeline includes development of an oral product candidate for treatment of ABSSSI (Acute Bacterial Skin and Skin Structure Infections), upon which a development program for treatment of inhaled anthrax is being planned in parallel.
To learn more about Acurx Pharmaceuticals and its product pipeline, please visitwww.acurxpharma.com