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Arthritis Rheumatol. 2020; 5. Russell SM, et al. Science. 1995;270(5237):797-800 - ATI-2138 covalently blocks ITK/JAK31 Potential for synergistic efficacy - ITK required for T cell receptor (TCR) signaling - JAK3 required for IL2R common cytokines (IL-2/4/7/9/15/21) - JAK3 is the only JAK that is inhibited - Tissue restricted expression could enhance safety - ATI-2138 is selective for T cell signaling2,3 - ATI-2138 has the potential to treat T cell-mediated autoimmune diseases4,5 - Phase 1 Single Ascending Dose Study successfully completed - Phase 1 Multiple Ascending Dose Study initiated - Phase 2a Proof of Concept study in Ulcerative Colitis under development Background Status Copyright 2023 Aclaris Therapeutics, Inc.
Medscape. Accessed January 7, 2023. https://emedicine.medscape.com/article/1049085-overview. 2. Silverberg J. Dermatol Clin. 2017;Jul;35(3):283-289; 3. Auster M, et al. Something Big Is Getting Bigger [research note]. Credit Suisse Equity Research; 2019; 4. Shreberk-Hassidim R, et al. J Am Acad Dermatol. 2017;Apr;76(4):745-753. Atopic dermatitis (AD) is a Goal chronic, pruritic inflammatory skin condition1 - The U.S. prevalence of AD is reported to be 11.3 12.7% in children and 6.9 7.6% in adults2 - Market projected to be $8-12 billion at peak (moderate to severe AD)3 - Systemic and topical JAK inhibition has demonstrated promising results in AD clinical trials4 - Comparable efficacy to other topical JAKs but a soft drug to minimize the potential for systemic toxicities - JAK1/3 selective to minimize JAK2 mediated hematopoietic effects - Patients with moderate to severe AD - Deliver in a patient-friendly formulation ATI-1777 (investigational compound) - First-in-human Phase 2a trial in subjects with moderate to severe AD completed - 4-week trial in subjects with moderate to severe AD completed with primary endpoint of % change from baseline in mEASI - Phase 2b dose ranging study underway Copyright 2023 Aclaris Therapeutics, Inc.
J Exp Med. 2018;215(5):1315-1325; Cheung P, et al. EMBO J. 2003;22(21):5793-5805; Muniyappa H, et al. Cell Signal. 2008;20(4):675 683;. Ma W, et al. J Biol Chem. 2001;276(17):13664-13674. The Path From p38 to MK2 p38 was initially targeted for suppressing TNF and other pro-inflammatory cytokines Global p38 inhibitors have exhibited toxicity and/or lack of sustained efficacy tachyphylaxis in RA and IBD p38 phosphorylates over 60 substrates yet MK2 drives the pro-inflammatory node of this pathway MK2 has been a high priority therapeutic target since 1999 but has proven very difficult to drug Inflammatory/Stress Stimuli p38 Anti-inflammatory Negative Feedback Cellular Function Pro-inflammatory MK2 TNF IL17 IL1 / IL6 IL8 Copyright 2023 Aclaris Therapeutics, Inc.
Nature Rev Drug Discov. Poster Jan. 2017; 4. Manning G, et al. Science. 2002;298(5600):1912-1934; 5. Oprea TI, et al. Nat Rev Drug Discov. 2018;17(5):317-332. Medically Important and Productive Target Class Most Members of the Kinome Remain Unexplored Oncology Non-Oncology >70 Marketed Drugs1 ~$48B2,3 Annual Sales of Kinase Drugs 518 Members >90% of the Human Kinome remains undrugged5 Creating New Medicines Targeting Previously Inaccessible Kinome Targets 4 Copyright 2023 Aclaris Therapeutics, Inc.
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