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Aclaris Therapeutics Announces Poster on Results from Phase 2a Trial of ATI-2138 at the 2026 American Academy of Dermatology (AAD) Annual Meeting

Key Takeaway: Aclaris Therapeutics announced that an ePoster detailing results from its Phase 2a trial of ATI-2138 will be available at the 2026 American Academy of Dermatology Annual Meeting. The trial focuses on patients with moderate-to-severe atopic dermatitis and showcases data that has not been previously reported. ATI-2138 is a potent investigational oral covalent inhibitor targeting interleukin-2-inducible T cell kinase (ITK) and Janus kinase 3 (JAK3). Aclaris aims to address the needs of patients who lack satisfactory treatment options for immuno-inflammatory diseases.

Market Sentiment Analysis

POSITIVE FACTORS

  • Aclaris is presenting new results from its Phase 2a trial, indicating progress in their research.
  • The investigational drug ATI-2138 holds potential as a treatment for moderate-to-severe atopic dermatitis.
  • Aclaris has a robust pipeline aimed at addressing unmet needs in immuno-inflammatory diseases.

Full Press Release Details

WAYNE, Pa., March 20, 2026 (GLOBE NEWSWIRE) -- Aclaris Therapeutics, Inc. (NASDAQ: ACRS), a clinical-stage biopharmaceutical company focused on developing novel product candidates for immuno-inflammatory diseases, today announced that an ePoster on the results from its open-label Phase 2a trial of ATI-2138, a potent and selective investigational oral covalent inhibitor of interleukin-2-inducible T cell kinase (ITK) and Janus kinase 3 (JAK3), will be available during the 2026 American Academy of Dermatology (AAD) Annual Meeting in Denver, CO. The poster will include results not previously reported from Aclaris’ Phase 2a trial in patients with moderate-to-severe atopic dermatitis (AD).
Electronic Poster Details:
Title Results from an Open-Label Phase 2 Trial of ATI-2138, an Investigational Oral Covalent Inhibitor of Interleukin-2-Inducible T Cell Kinase (ITK) And Janus Kinase 3 (JAK3), in Patients with Moderate-To-Severe Atopic Dermatitis
Authors Ajay Aggarwal 1 , Aparna Kaul 1 , Loreen Stillwell 1 , Nancy McGraw 1 , Robert Mahe 1 , Rakesh Basavalingappa 1 , Emma Huff 1 , David R. Anderson 1 , Emma Guttman 2 , Joseph Monahan 1 , Neal Walker 1
Affiliations: 1 Aclaris Therapeutics Inc.; 2 Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY
About Aclaris Therapeutics, Inc.
Aclaris Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing a pipeline of novel product candidates to address the needs of patients with immuno-inflammatory diseases who lack satisfactory treatment options. The company has a multi-stage portfolio of product candidates powered by a robust R&D engine. For additional information, please visit www.aclaristx.com and follow Aclaris on LinkedIn.
Aclaris Therapeutics Contact:
Senior Vice President
Corporate Communications and Investor Relations

Frequently Asked Questions

What is Aclaris Therapeutics focused on?

Aclaris Therapeutics specializes in developing new treatments for immuno-inflammatory diseases.

What trial results will Aclaris present at AAD 2026?

Aclaris will showcase an ePoster on the Phase 2a trial results of ATI-2138.

What is ATI-2138?

ATI-2138 is an oral covalent inhibitor targeting ITK and JAK3 for atopic dermatitis.

Who authored the ePoster on ATI-2138?

The ePoster is authored by Aclaris researchers and experts from Mount Sinai.

Where can I find more information about Aclaris?

More information is available on Aclaris’ website and their LinkedIn page.

Last updated: Mar 20, 2026